Marcel Kool

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1997 …2023

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Search results

  • 2018

    Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups

    Archer, T. C., Ehrenberger, T., Mundt, F., Gold, M. P., Krug, K., Mah, C. K., Mahoney, E. L., Daniel, C. J., LeNail, A., Ramamoorthy, D., Mertins, P., Mani, D. R., Zhang, H., Gillette, M. A., Clauser, K., Noble, M., Tang, L. C., Pierre-François, J., Silterra, J., Jensen, J., & 11 othersTamayo, P., Korshunov, A., Pfister, S. M., Kool, M., Northcott, P. A., Sears, R. C., Lipton, J. O., Carr, S. A., Mesirov, J. P., Pomeroy, S. L. & Fraenkel, E., 10 Sept 2018, In: Cancer Cell. 34, 3, p. 396-410.e8

    Research output: Contribution to journalArticlepeer-review

    121 Citations (Scopus)
  • Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

    Robinson, G. W., Rudneva, V. A., Buchhalter, I., Billups, C. A., Waszak, S. M., Smith, K. S., Bowers, D. C., Bendel, A., Fisher, P. G., Partap, S., Crawford, J. R., Hassall, T., Indelicato, D. J., Boop, F., Klimo, P., Sabin, N. D., Patay, Z., Merchant, T. E., Stewart, C. F., Orr, B. A., & 13 othersKorbel, J. O., Jones, D. T. W., Sharma, T., Lichter, P., Kool, M., Korshunov, A., Pfister, S. M., Gilbertson, R. J., Sanders, R. P., Onar-Thomas, A., Ellison, D. W., Gajjar, A. & Northcott, P. A., Jun 2018, In: The Lancet Oncology. 19, 6, p. 768-784 17 p.

    Research output: Contribution to journalArticlepeer-review

    154 Citations (Scopus)
  • Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup

    Johann, P. D., Bens, S., Oyen, F., Wagener, R., Giannini, C., Perry, A., Raisanen, J. M., Reis, G. F., Nobusawa, S., Arita, K., Felsberg, J., Reifenberger, G., Agaimy, A., Buslei, R., Capper, D., Pfister, S. M., Schneppenheim, R., Siebert, R., Frühwald, M. C., Paulus, W., & 2 othersKool, M. & Hasselblatt, M., 2018, In: American Journal of Surgical Pathology. 42, 4, p. 506-511 6 p.

    Research output: Contribution to journalArticlepeer-review

    39 Citations (Scopus)
  • Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

    Waszak, S. M., Northcott, P. A., Buchhalter, I., Robinson, G. W., Sutter, C., Groebner, S., Grund, K. B., Brugières, L., Jones, D. T. W., Pajtler, K. W., Morrissy, A. S., Kool, M., Sturm, D., Chavez, L., Ernst, A., Brabetz, S., Hain, M., Zichner, T., Segura-Wang, M., Weischenfeldt, J., & 67 othersRausch, T., Mardin, B. R., Zhou, X., Baciu, C., Lawerenz, C., Chan, J. A., Varlet, P., Guerrini-Rousseau, L., Fults, D. W., Grajkowska, W., Hauser, P., Jabado, N., Ra, Y. S., Zitterbart, K., Shringarpure, S. S., De La Vega, F. M., Bustamante, C. D., Ng, H. K., Perry, A., MacDonald, T. J., Hernáiz Driever, P., Bendel, A. E., Bowers, D. C., McCowage, G., Chintagumpala, M. M., Cohn, R., Hassall, T., Fleischhack, G., Eggen, T., Wesenberg, F., Feychting, M., Lannering, B., Schüz, J., Johansen, C., Andersen, T. V., Röösli, M., Kuehni, C. E., Grotzer, M., Kjaerheim, K., Monoranu, C. M., Archer, T. C., Duke, E., Pomeroy, S. L., Shelagh, R., Frank, S., Sumerauer, D., Scheurlen, W., Ryzhova, M. V., Milde, T., Kratz, C. P., Samuel, D., Zhang, J., Solomon, D. A., Marra, M., Eils, R., Bartram, C. R., von Hoff, K., Rutkowski, S., Ramaswamy, V., Gilbertson, R. J., Korshunov, A., Taylor, M. D., Lichter, P., Malkin, D., Gajjar, A., Korbel, J. O. & Pfister, S. M., Jun 2018, In: The Lancet Oncology. 19, 6, p. 785-798 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    239 Citations (Scopus)
  • The landscape of genomic alterations across childhood cancers

    Gröbner, S. N., Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., Segura-Wang, M., Brabetz, S., Bender, S., Hutter, B., Sturm, D., Pfaff, E., Hübschmann, D., Zipprich, G., Heinold, M., Eils, J., Lawerenz, C., Erkek, S., & 64 othersLambo, S., Waszak, S., Blattmann, C., Borkhardt, A., Kuhlen, M., Eggert, A., Fulda, S., Gessler, M., Wegert, J., Kappler, R., Baumhoer, D., Burdach, S., Kirschner-Schwabe, R., Kontny, U., Kulozik, A. E., Lohmann, D., Hettmer, S., Eckert, C., Bielack, S., Nathrath, M., Niemeyer, C., Richter, G. H., Schulte, J., Siebert, R., Westermann, F., Molenaar, J. J., Vassal, G., Witt, H., Zapatka, M., Burkhardt, B., Kratz, C. P., Witt, O., Tilburg, C. M. V., Kramm, C. M., Fleischhack, G., Dirksen, U., Rutkowski, S., Frühwald, M., Hoff, K. V., Wolf, S., Klingebiel, T., Koscielniak, E., Landgraf, P., Koster, J., Resnick, A. C., Zhang, J., Liu, Y., Zhou, X., Waanders, A. J., Zwijnenburg, D. A., Raman, P., Brors, B., Weber, U. D., Northcott, P. A., Pajtler, K. W., Kool, M., Piro, R. M., Korbel, J. O., Schlesner, M., Eils, R., Jones, D. T. W., Lichter, P., Chavez, L. & Pfister, S. M., 15 Mar 2018, In: Nature. 555, 7696, p. 321-327 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    880 Citations (Scopus)
  • Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

    Mack, S. C., Pajtler, K. W., Chavez, L., Okonechnikov, K., Bertrand, K. C., Wang, X., Erkek, S., Federation, A., Song, A., Lee, C., Wang, X., McDonald, L., Morrow, J. J., Saiakhova, A., Sin-Chan, P., Wu, Q., Michaelraj, K. A., Miller, T. E., Hubert, C. G., Ryzhova, M., & 55 othersGarzia, L., Donovan, L., Dombrowski, S., Factor, D. C., Luu, B., Valentim, C. L. L., Gimple, R. C., Morton, A., Kim, L., Prager, B. C., Lee, J. J. Y., Wu, X., Zuccaro, J., Thompson, Y., Holgado, B. L., Reimand, J., Ke, S. Q., Tropper, A., Lai, S., Vijayarajah, S., Doan, S., Mahadev, V., Miñan, A. F., Gröbner, S. N., Lienhard, M., Zapatka, M., Huang, Z., Aldape, K. D., Carcaboso, A. M., Houghton, P. J., Keir, S. T., Milde, T., Witt, H., Li, Y., Li, C. J., Bian, X. W., Jones, D. T. W., Scott, I., Singh, S. K., Huang, A., Dirks, P. B., Bouffet, E., Bradner, J. E., Ramaswamy, V., Jabado, N., Rutka, J. T., Northcott, P. A., Lupien, M., Lichter, P., Korshunov, A., Scacheri, P. C., Pfister, S. M., Kool, M., Taylor, M. D. & Rich, J. N., 4 Jan 2018, In: Nature. 553, 7686, p. 101-105 5 p.

    Research output: Contribution to journalArticlepeer-review

    155 Citations (Scopus)
  • 2017

    A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

    Neumann, J. E., Wefers, A. K., Lambo, S., Bianchi, E., Bockstaller, M., Dorostkar, M. M., Meister, V., Schindler, P., Korshunov, A., Von Hoff, K., Nowak, J., Warmuth-Metz, M., Schneider, M. R., Renner-Müller, I., Merk, D. J., Shakarami, M., Sharma, T., Chavez, L., Glass, R., Chan, J. A., & 4 othersTaketo, M. M., Neumann, P., Kool, M. & Schüller, U., 1 Oct 2017, In: Nature Medicine. 23, 10, p. 1191-1202 12 p.

    Research output: Contribution to journalArticlepeer-review

    34 Citations (Scopus)
  • Atypical teratoid/rhabdoid tumor arising in a malignant glioma

    Bozzai, B., Hasselblatt, M., Turányi, E., Frühwald, M. C., Siebert, R., Bens, S., Schneppenheim, R., Kool, M., Stelczer, G., Hortobágyi, T. & Hauser, P., 1 Jan 2017, In: Pediatric Blood and Cancer. 64, 1, p. 96-99 4 p.

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)
  • Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

    Feng, W., Kawauchi, D., Körkel-Qu, H., Deng, H., Serger, E., Sieber, L., Ariel Lieberman, J., Jimeno-Gonzalez, S., Lambo, S., Hanna, B. S., Harim, Y., Jansen, M., Neuerburg, A., Friesen, O., Zuckermann, M., Rajendran, V., Gronych, J., Ayrault, O., Korshunov, A., Jones, D. T. W., & 6 othersKool, M., Northcott, P. A., Lichter, P., Cortés-Ledesma, F., Pfister, S. M. & Liu, H. K., 20 Mar 2017, In: Nature Communications. 8, 14758.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    96 Citations (Scopus)
  • Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors

    Moreno, N., Holsten, T., Mertins, J., Zhogbi, A., Johann, P., Kool, M., Meisterernst, M. & Kerl, K., 17 Oct 2017, In: Oncotarget. 8, 49, p. 84986-84995 10 p.

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)
  • Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome

    Johann, P. D., Hovestadt, V., Thomas, C., Jeibmann, A., Heß, K., Bens, S., Oyen, F., Hawkins, C., Pierson, C. R., Aldape, K., Kim, S. P., Widing, E., Sumerauer, D., Hauser, P., van Landeghem, F., Ryzhova, M., Korshunov, A., Capper, D., Jones, D. T. W., Pfister, S. M., & 6 othersSchneppenheim, R., Siebert, R., Paulus, W., Frühwald, M. C., Kool, M. & Hasselblatt, M., Jul 2017, In: Brain Pathology. 27, 4, p. 411-418 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    60 Citations (Scopus)
  • DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma

    Korshunov, A., Chavez, L., Northcott, P. A., Sharma, T., Ryzhova, M., Jones, D. T. W., von Deimling, A., Pfister, S. M. & Kool, M., 1 Dec 2017, In: Acta Neuropathologica. 134, 6, p. 965-967 3 p.

    Research output: Contribution to journalLetterpeer-review

    31 Citations (Scopus)
  • Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation

    Sandén, E., Dyberg, C., Krona, C., Gallo-Oller, G., Olsen, T. K., Enríquez Pérez, J., Wickström, M., Estekizadeh, A., Kool, M., Visse, E., Ekström, T. J., Siesjö, P., Inge Johnsen, J. & Darabi, A., 18 Apr 2017, In: Scientific Reports. 7, 46366.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Citations (Scopus)
  • Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data

    Mynarek, M., Pizer, B., Dufour, C., van Vuurden, D., Garami, M., Massimino, M., Fangusaro, J., Davidson, T., Gil-da-Costa, M. J., Sterba, J., Benesch, M., Gerber, N., Juhnke, B. O., Kwiecien, R., Pietsch, T., Kool, M., Clifford, S., Ellison, D. W., Giangaspero, F., Wesseling, P., & 5 othersGilles, F., Gottardo, N., Finlay, J. L., Rutkowski, S. & von Hoff, K., 1 Apr 2017, In: Neuro-Oncology. 19, 4, p. 576-585 10 p.

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)
  • Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor

    Wu, X., Zhang, L. S., Toombs, J., Kuo, Y. C., Piazza, J. T., Tuladhar, R., Barrett, Q., Fan, C. W., Zhang, X., Walensky, L. D., Kool, M., Cheng, S. Y., Brekken, R., Opferman, J. T., Green, D. R., Moldoveanu, T. & Lum, L., 29 Sept 2017, In: Nature Cell Biology. 19, 10, p. 1226-1236 11 p.

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)
  • HGNET-BCOR Tumors of the Cerebellum: Clinicopathologic and Molecular Characterization of 3 Cases

    Appay, R., Macagno, N., Padovani, L., Korshunov, A., Kool, M., André, N., Scavarda, D., Pietsch, T. & Figarella-Branger, D., 2017, In: American Journal of Surgical Pathology. 41, 9, p. 1254-1260 7 p.

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)
  • Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

    Panwalkar, P., Clark, J., Ramaswamy, V., Hawes, D., Yang, F., Dunham, C., Yip, S., Hukin, J., Sun, Y., Schipper, M. J., Chavez, L., Margol, A., Pekmezci, M., Chung, C., Banda, A., Bayliss, J. M., Curry, S. J., Santi, M., Rodriguez, F. J., Snuderl, M., & 20 othersKarajannis, M. A., Saratsis, A. M., Horbinski, C. M., Carret, A. S., Wilson, B., Johnston, D., Lafay-Cousin, L., Zelcer, S., Eisenstat, D., Silva, M., Scheinemann, K., Jabado, N., McNeely, P. D., Kool, M., Pfister, S. M., Taylor, M. D., Hawkins, C., Korshunov, A., Judkins, A. R. & Venneti, S., 1 Nov 2017, In: Acta Neuropathologica. 134, 5, p. 705-714 10 p.

    Research output: Contribution to journalArticlepeer-review

    158 Citations (Scopus)
  • Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells

    Kawauchi, D., Ogg, R. J., Liu, L., Shih, D. J. H., Finkelstein, D., Murphy, B. L., Rehg, J. E., Korshunov, A., Calabrese, C., Zindy, F., Phoenix, T., Kawaguchi, Y., Gronych, J., Gilbertson, R. J., Lichter, P., Gajjar, A., Kool, M., Northcott, P. A., Pfister, S. M. & Roussel, M. F., 14 Sept 2017, In: Oncogene. 36, 37, p. 5231-5242 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    33 Citations (Scopus)
  • Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications

    Senfter, D., Erkan, E. P., Özer, E., Jungwirth, G., Madlener, S., Kool, M., Ströbel, T., Saydam, N. & Saydam, O., Dec 2017, In: Pediatric Blood and Cancer. 64, 12, e26670.

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)
  • PDX-MI: Minimal information for patient-derived tumor xenograft models

    Meehan, T. F., Conte, N., Goldstein, T., Inghirami, G., Murakami, M. A., Brabetz, S., Gu, Z., Wiser, J. A., Dunn, P., Begley, D. A., Krupke, D. M., Bertotti, A., Bruna, A., Brush, M. H., Byrne, A. T., Caldas, C., Christie, A. L., Clark, D. A., Dowst, H., Dry, J. R., & 34 othersDoroshow, J. H., Duchamp, O., Evrard, Y. A., Ferretti, S., Frese, K. K., Goodwin, N. C., Greenawalt, D., Haendel, M. A., Hermans, E., Houghton, P. J., Jonkers, J., Kemper, K., Khor, T. O., Lewis, M. T., Lloyd, K. C. K., Mason, J., Medico, E., Neuhauser, S. B., Olson, J. M., Peeper, D. S., Rueda, O. M., Seong, J. K., Trusolino, L., Vinolo, E., Wechsler-Reya, R. J., Weinstock, D. M., Welm, A., Weroha, S. J., Amant, F., Pfister, S. M., Kool, M., Parkinson, H., Butte, A. J. & Bult, C. J., 1 Nov 2017, In: Cancer Research. 77, 21, p. e62-e66

    Research output: Contribution to journalArticlepeer-review

    83 Citations (Scopus)
  • Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients

    Schmidt, C., Schubert, N. A., Brabetz, S., Mack, N., Schwalm, B., Chan, J. A., Selt, F., Herold-Mende, C., Witt, O., Milde, T., Pfister, S. M., Korshunov, A. & Kool, M., 1 Dec 2017, In: Neuro-Oncology. 19, 12, p. 1607-1617 11 p.

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)
  • Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome

    Hasselblatt, M., Johann, P. D., Kool, M. & Frühwald, M. C., 1 Nov 2017, In: Acta Neuropathologica. 134, 5, p. 817-818 2 p.

    Research output: Contribution to journalLetterpeer-review

    4 Citations (Scopus)
  • SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors

    Jeibmann, A., Schulz, J., Eikmeier, K., Johann, P. D., Thiel, K., Tegeder, I., Ambrée, O., Frühwald, M. C., Pfister, S. M., Kool, M., Paulus, W. & Hasselblatt, M., 1 Feb 2017, In: Journal of Neuro-Oncology. 131, 3, p. 477-484 8 p.

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)
  • Spatial heterogeneity in medulloblastoma

    Morrissy, A. S., Cavalli, F. M. G., Remke, M., Ramaswamy, V., Shih, D. J. H., Holgado, B. L., Farooq, H., Donovan, L. K., Garzia, L., Agnihotri, S., Kiehna, E. N., Mercier, E., Mayoh, C., Papillon-Cavanagh, S., Nikbakht, H., Gayden, T., Torchia, J., Picard, D., Merino, D. M., Vladoiu, M., & 59 othersLuu, B., Wu, X., Daniels, C., Horswell, S., Thompson, Y. Y., Hovestadt, V., Northcott, P. A., Jones, D. T. W., Peacock, J., Wang, X., Mack, S. C., Reimand, J., Albrecht, S., Fontebasso, A. M., Thiessen, N., Li, Y., Schein, J. E., Lee, D., Carlsen, R., Mayo, M., Tse, K., Tam, A., Dhalla, N., Ally, A., Chuah, E., Cheng, Y., Plettner, P., Li, H. I., Corbett, R. D., Wong, T., Long, W., Loukides, J., Buczkowicz, P., Hawkins, C. E., Tabori, U., Rood, B. R., Myseros, J. S., Packer, R. J., Korshunov, A., Lichter, P., Kool, M., Pfister, S. M., Schüller, U., Dirks, P., Huang, A., Bouffet, E., Rutka, J. T., Bader, G. D., Swanton, C., Ma, Y., Moore, R. A., Mungall, A. J., Majewski, J., Jones, S. J. M., Das, S., Malkin, D., Jabado, N., Marra, M. A. & Taylor, M. D., 1 May 2017, In: Nature Genetics. 49, 5, p. 780-788 9 p.

    Research output: Contribution to journalArticlepeer-review

    94 Citations (Scopus)
  • Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor

    Alimova, I., Pierce, A. M., Harris, P., Donson, A., Birks, D. K., Prince, E., Balakrishnan, I., Foreman, N. K., Kool, M., Hoffman, L., Venkataraman, S. & Vibhakar, R., 2017, In: Oncotarget. 8, 57, p. 97290-97303 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    12 Citations (Scopus)
  • Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain

    Gojo, J., Lötsch, D., Spiegl-Kreinecker, S., Pajtler, K. W., Neumayer, K., Korbel, P., Araki, A., Brandstetter, A., Mohr, T., Hovestadt, V., Chavez, L., Kirchhofer, D., Ricken, G., Stefanits, H., Korshunov, A., Pfister, S. M., Dieckmann, K., Azizi, A. A., Czech, T., Filipits, M., & 5 othersKool, M., Peyrl, A., Slavc, I., Berger, W. & Haberler, C., 1 Sept 2017, In: Neuro-Oncology. 19, 9, p. 1183-1194 12 p.

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)
  • The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

    Pajtler, K. W., Mack, S. C., Ramaswamy, V., Smith, C. A., Witt, H., Smith, A., Hansford, J. R., von Hoff, K., Wright, K. D., Hwang, E., Frappaz, D., Kanemura, Y., Massimino, M., Faure-Conter, C., Modena, P., Tabori, U., Warren, K. E., Holland, E. C., Ichimura, K., Giangaspero, F., & 16 othersCastel, D., von Deimling, A., Kool, M., Dirks, P. B., Grundy, R. G., Foreman, N. K., Gajjar, A., Korshunov, A., Finlay, J., Gilbertson, R. J., Ellison, D. W., Aldape, K. D., Merchant, T. E., Bouffet, E., Pfister, S. M. & Taylor, M. D., 1 Jan 2017, In: Acta Neuropathologica. 133, 1, p. 5-12 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    242 Citations (Scopus)
  • The whole-genome landscape of medulloblastoma subtypes

    Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., Warnatz, H. J., Sidiropoulos, N., Phillips, A. H., Schumacher, S., Kleinheinz, K., Waszak, S. M., Erkek, S., Jones, D. T. W., Worst, B. C., Kool, M., & 67 othersZapatka, M., Jäger, N., Chavez, L., Hutter, B., Bieg, M., Paramasivam, N., Heinold, M., Gu, Z., Ishaque, N., Jäger-Schmidt, C., Imbusch, C. D., Jugold, A., Hübschmann, D., Risch, T., Amstislavskiy, V., Gonzalez, F. G. R., Weber, U. D., Wolf, S., Robinson, G. W., Zhou, X., Wu, G., Finkelstein, D., Liu, Y., Cavalli, F. M. G., Luu, B., Ramaswamy, V., Wu, X., Koster, J., Ryzhova, M., Cho, Y. J., Pomeroy, S. L., Herold-Mende, C., Schuhmann, M., Ebinger, M., Liau, L. M., Mora, J., McLendon, R. E., Jabado, N., Kumabe, T., Chuah, E., Ma, Y., Moore, R. A., Mungall, A. J., Mungall, K. L., Thiessen, N., Tse, K., Wong, T., Jones, S. J. M., Witt, O., Milde, T., Von Deimling, A., Capper, D., Korshunov, A., Yaspo, M. L., Kriwacki, R., Gajjar, A., Zhang, J., Beroukhim, R., Fraenkel, E., Korbel, J. O., Brors, B., Schlesner, M., Eils, R., Marra, M. A., Pfister, S. M., Taylor, M. D. & Lichter, P., 19 Jul 2017, In: Nature. 547, 7663, p. 311-317 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    676 Citations (Scopus)
  • 2016

    Active medulloblastoma enhancers reveal subgroup-specific cellular origins

    Lin, C. Y., Erkek, S., Tong, Y., Yin, L., Federation, A. J., Zapatka, M., Haldipur, P., Kawauchi, D., Risch, T., Warnatz, H. J., Worst, B. C., Ju, B., Orr, B. A., Zeid, R., Polaski, D. R., Segura-Wang, M., Waszak, S. M., Jones, D. T. W., Kool, M., Hovestadt, V., & 19 othersBuchhalter, I., Sieber, L., Johann, P., Chavez, L., Gröschel, S., Ryzhova, M., Korshunov, A., Chen, W., Chizhikov, V. V., Millen, K. J., Amstislavskiy, V., Lehrach, H., Yaspo, M. L., Eils, R., Lichter, P., Korbel, J. O., Pfister, S. M., Bradner, J. E. & Northcott, P. A., 4 Feb 2016, In: Nature. 530, 7588, p. 57-62 6 p.

    Research output: Contribution to journalArticlepeer-review

    265 Citations (Scopus)
  • Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

    Hölsken, A., Sill, M., Merkle, J., Schweizer, L., Buchfelder, M., Flitsch, J., Fahlbusch, R., Metzler, M., Kool, M., Pfister, S. M., von Deimling, A., Capper, D., Jones, D. T. W. & Buslei, R., 29 Feb 2016, In: Acta neuropathologica communications. 4, p. 20 1 p.

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    Open Access
    127 Citations (Scopus)
  • Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

    Johann, P. D., Erkek, S., Zapatka, M., Kerl, K., Buchhalter, I., Hovestadt, V., Jones, D. T. W., Sturm, D., Hermann, C., Segura Wang, M., Korshunov, A., Rhyzova, M., Gröbner, S., Brabetz, S., Chavez, L., Bens, S., Gröschel, S., Kratochwil, F., Wittmann, A., Sieber, L., & 38 othersGeörg, C., Wolf, S., Beck, K., Oyen, F., Capper, D., van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., von Deimling, A., Milde, T., Witt, O., Kulozik, A. E., Ebinger, M., Shalaby, T., Grotzer, M., Sumerauer, D., Zamecnik, J., Mora, J., Jabado, N., Taylor, M. D., Huang, A., Aronica, E., Bertoni, A., Radlwimmer, B., Pietsch, T., Schüller, U., Schneppenheim, R., Northcott, P. A., Korbel, J. O., Siebert, R., Frühwald, M. C., Lichter, P., Eils, R., Gajjar, A., Hasselblatt, M., Pfister, S. M. & Kool, M., 14 Mar 2016, In: Cancer Cell. 29, 3, p. 379-393 15 p.

    Research output: Contribution to journalArticlepeer-review

    398 Citations (Scopus)
  • Divergent clonal selection dominates medulloblastoma at recurrence

    Morrissy, A. S., Garzia, L., Shih, D. J. H., Zuyderduyn, S., Huang, X., Skowron, P., Remke, M., Cavalli, F. M. G., Ramaswamy, V., Lindsay, P. E., Jelveh, S., Donovan, L. K., Wang, X., Luu, B., Zayne, K., Li, Y., Mayoh, C., Thiessen, N., Mercier, E., Mungall, K. L., & 118 othersMa, Y., Tse, K., Zeng, T., Shumansky, K., Roth, A. J. L., Shah, S., Farooq, H., Kijima, N., Holgado, B. L., Lee, J. J. Y., Matan-Lithwick, S., Liu, J., Mack, S. C., Manno, A., Michealraj, K. A., Nor, C., Peacock, J., Qin, L., Reimand, J., Rolider, A., Thompson, Y. Y., Wu, X., Pugh, T., Ally, A., Bilenky, M., Butterfield, Y. S. N., Carlsen, R., Cheng, Y., Chuah, E., Corbett, R. D., Dhalla, N., He, A., Lee, D., Li, H. I., Long, W., Mayo, M., Plettner, P., Qian, J. Q., Schein, J. E., Tam, A., Wong, T., Birol, I., Zhao, Y., Faria, C. C., Pimentel, J., Nunes, S., Shalaby, T., Grotzer, M., Pollack, I. F., Hamilton, R. L., Li, X. N., Bendel, A. E., Fults, D. W., Walter, A. W., Kumabe, T., Tominaga, T., Collins, V. P., Cho, Y. J., Hoffman, C., Lyden, D., Wisoff, J. H., Garvin, J. H., Stearns, D. S., Massimi, L., Schüller, U., Sterba, J., Zitterbart, K., Puget, S., Ayrault, O., Dunn, S. E., Tirapelli, D. P. C., Carlotti, C. G., Wheeler, H., Hallahan, A. R., Ingram, W., MacDonald, T. J., Olson, J. J., Van Meir, E. G., Lee, J. Y., Wang, K. C., Kim, S. K., Cho, B. K., Pietsch, T., Fleischhack, G., Tippelt, S., Ra, Y. S., Bailey, S., Lindsey, J. C., Clifford, S. C., Eberhart, C. G., Cooper, M. K., Packer, R. J., Massimino, M., Garre, M. L., Bartels, U., Tabori, U., Hawkins, C. E., Dirks, P., Bouffet, E., Rutka, J. T., Wechsler-Reya, R. J., Weiss, W. A., Collier, L. S., Dupuy, A. J., Korshunov, A., Jones, D. T. W., Kool, M., Northcott, P. A., Pfister, S. M., Largaespada, D. A., Mungall, A. J., Moore, R. A., Jabado, N., Bader, G. D., Jones, S. J. M., Malkin, D., Marra, M. A. & Taylor, M. D., 21 Jan 2016, In: Nature. 529, 7586, p. 351-357 7 p.

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    240 Citations (Scopus)
  • FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

    Suryo Rahmanto, A., Savov, V., Brunner, A., Bolin, S., Weishaupt, H., Malyukova, A., Rosén, G., Čančer, M., Hutter, S., Sundström, A., Kawauchi, D., Jones, D. T. W., Spruck, C., Taylor, M. D., Cho, Y. J., Pfister, S. M., Kool, M., Korshunov, A., Swartling, F. J. & Sangfelt, O., 17 Oct 2016, In: EMBO Journal. 35, 20, p. 2192-2212 21 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    53 Citations (Scopus)
  • Gain of 1q as a prognostic biomarker in Wilms Tumors (WTs) treated with preoperative chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 trial: A SIOP renal tumours biology consortium study

    Chagtai, T., Zill, C., Dainese, L., Wegert, J., Savola, S., Popov, S., Mifsud, W., Vujanić, G., Sebire, N., Le Bouc, Y., Ambros, P. F., Kager, L., O'Sullivan, M. J., Blaise, A., Bergeron, C., Mengelbier, L. H., Gisselsson, D., Kool, M., Tytgat, G. A. M., Van Den Heuvel-Eibrink, M. M., & 6 othersGraf, N., Van Tinteren, H., Coulomb, A., Gessler, M., Williams, R. D. & Pritchard-Jones, K., 10 Sept 2016, In: Journal of Clinical Oncology. 34, 26, p. 3195-3203 9 p.

    Research output: Contribution to journalArticlepeer-review

    94 Citations (Scopus)
  • HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

    Pei, Y., Liu, K. W., Wang, J., Garancher, A., Tao, R., Esparza, L. A., Maier, D. L., Udaka, Y. T., Murad, N., Morrissy, S., Seker-Cin, H., Brabetz, S., Qi, L., Kogiso, M., Schubert, S., Olson, J. M., Cho, Y. J., Li, X. N., Crawford, J. R., Levy, M. L., & 4 othersKool, M., Pfister, S. M., Taylor, M. D. & Wechsler-Reya, R. J., 14 Mar 2016, In: Cancer Cell. 29, 3, p. 311-323 13 p.

    Research output: Contribution to journalArticlepeer-review

    187 Citations (Scopus)
  • Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

    Korshunov, A., Capper, D., Reuss, D., Schrimpf, D., Ryzhova, M., Hovestadt, V., Sturm, D., Meyer, J., Jones, C., Zheludkova, O., Kumirova, E., Golanov, A., Kool, M., Schüller, U., Mittelbronn, M., Hasselblatt, M., Schittenhelm, J., Reifenberger, G., Herold-Mende, C., Lichter, P., & 3 othersvon Deimling, A., Pfister, S. M. & Jones, D. T. W., 1 Jan 2016, In: Acta Neuropathologica. 131, 1, p. 137-146 10 p.

    Research output: Contribution to journalArticlepeer-review

    156 Citations (Scopus)
  • Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma

    Tzaridis, T., Milde, T., Pajtler, K. W., Bender, S., Jones, D. T. W., Müller, S., Wittmann, A., Schlotter, M., Kulozik, A. E., Lichter, P., Collins, V. P., Witt, O., Kool, M., Korshunov, A., Pfister, S. M. & Witt, H., 2016, In: Oncotarget. 7, 38, p. 61860-61873 14 p.

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)
  • Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

    Oh, S., Flynn, R. A., Floor, S. N., Purzner, J., Martin, L., Do, B. T., Schubert, S., Vaka, D., Morrissy, S., Li, Y., Kool, M., Hovestadt, V., Jones, D. T. W., Northcott, P. A., Risch, T., Warnatz, H. J., Yaspo, M. L., Adams, C. M., Leib, R. D., Breese, M., & 8 othersMarra, M. A., Malkin, D., Lichter, P., Doudna, J. A., Pfister, S. M., Taylor, M. D., Chang, H. Y. & Cho, Y. J., 10 May 2016, In: Oncotarget. 7, 19, p. 28169-28182 14 p.

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    52 Citations (Scopus)
  • Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor

    Fahiminiya, S., Witkowski, L., Nadaf, J., Carrot-Zhang, J., Goudie, C., Hasselblatt, M., Johann, P., Kool, M., Lee, R. S., Gayden, T., Roberts, C. W. M., Biegel, J. A., Jabado, N., Majewski, J. & Foulkes, W. D., 2016, In: Oncotarget. 7, 2, p. 1732-1740 9 p.

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)
  • New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Sturm, D., Orr, B. A., Toprak, U. H., Hovestadt, V., Jones, D. T. W., Capper, D., Sill, M., Buchhalter, I., Northcott, P. A., Leis, I., Ryzhova, M., Koelsche, C., Pfaff, E., Allen, S. J., Balasubramanian, G., Worst, B. C., Pajtler, K. W., Brabetz, S., Johann, P. D., Sahm, F., & 90 othersReimand, J., Mackay, A., Carvalho, D. M., Remke, M., Phillips, J. J., Perry, A., Cowdrey, C., Drissi, R., Fouladi, M., Giangaspero, F., Łastowska, M., Grajkowska, W., Scheurlen, W., Pietsch, T., Hagel, C., Gojo, J., Lötsch, D., Berger, W., Slavc, I., Haberler, C., Jouvet, A., Holm, S., Hofer, S., Prinz, M., Keohane, C., Fried, I., Mawrin, C., Scheie, D., Mobley, B. C., Schniederjan, M. J., Santi, M., Buccoliero, A. M., Dahiya, S., Kramm, C. M., Von Bueren, A. O., Von Hoff, K., Rutkowski, S., Herold-Mende, C., Frühwald, M. C., Milde, T., Hasselblatt, M., Wesseling, P., Rößler, J., Schüller, U., Ebinger, M., Schittenhelm, J., Frank, S., Grobholz, R., Vajtai, I., Hans, V., Schneppenheim, R., Zitterbart, K., Collins, V. P., Aronica, E., Varlet, P., Puget, S., Dufour, C., Grill, J., Figarella-Branger, D., Wolter, M., Schuhmann, M. U., Shalaby, T., Grotzer, M., Van Meter, T., Monoranu, C. M., Felsberg, J., Reifenberger, G., Snuderl, M., Forrester, L. A., Koster, J., Versteeg, R., Volckmann, R., Van Sluis, P., Wolf, S., Mikkelsen, T., Gajjar, A., Aldape, K., Moore, A. S., Taylor, M. D., Jones, C., Jabado, N., Karajannis, M. A., Eils, R., Schlesner, M., Lichter, P., Von Deimling, A., Pfister, S. M., Ellison, D. W., Korshunov, A. & Kool, M., 25 Feb 2016, In: Cell. 164, 5, p. 1060-1072 13 p.

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    Open Access
    612 Citations (Scopus)
  • Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

    Sahm, F., Schrimpf, D., Jones, D. T. W., Meyer, J., Kratz, A., Reuss, D., Capper, D., Koelsche, C., Korshunov, A., Wiestler, B., Buchhalter, I., Milde, T., Selt, F., Sturm, D., Kool, M., Hummel, M., Bewerunge-Hudler, M., Mawrin, C., Schüller, U., Jungk, C., & 8 othersWick, A., Witt, O., Platten, M., Herold-Mende, C., Unterberg, A., Pfister, S. M., Wick, W. & von Deimling, A., 1 Jun 2016, In: Acta Neuropathologica. 131, 6, p. 903-910 8 p.

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    187 Citations (Scopus)
  • Papillary tumor of the pineal region: A distinct molecular entity

    Heim, S., Sill, M., Jones, D. T. W., Vasiljevic, A., Jouvet, A., Fèvre-Montange, M., Wesseling, P., Beschorner, R., Mittelbronn, M., Kohlhof, P., Hovestadt, V., Johann, P., Kool, M., Pajtler, K. W., Korshunov, A., Ruland, V., Sperveslage, J., Thomas, C., Witt, H., Von Deimling, A., & 4 othersPaulus, W., Pfister, S. M., Capper, D. & Hasselblatt, M., 1 Mar 2016, In: Brain Pathology. 26, 2, p. 199-205 7 p.

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    Open Access
    32 Citations (Scopus)
  • PNR-12GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR)

    Lambo, S., Bunt, J., Schmidt, C., Pfister, S. M., Richards, L. J., Chavez, L., Korshunov, A. & Kool, M., Jun 2016, In: Neuro-Oncology. 18, suppl 3, p. iii9.2-iii9

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    Open Access
  • Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis

    Hasselblatt, M., Thomas, C., Hovestadt, V., Schrimpf, D., Johann, P., Bens, S., Oyen, F., Peetz-Dienhart, S., Crede, Y., Wefers, A., Vogel, H., Riemenschneider, M. J., Antonelli, M., Giangaspero, F., Bernardo, M. C., Giannini, C., Ud Din, N., Perry, A., Keyvani, K., van Landeghem, F., & 10 othersSumerauer, D., Hauser, P., Capper, D., Korshunov, A., Jones, D. T. W., Pfister, S. M., Schneppenheim, R., Siebert, R., Frühwald, M. C. & Kool, M., 1 Jul 2016, In: Acta Neuropathologica. 132, 1, p. 149-151 3 p.

    Research output: Contribution to journalLetterpeer-review

    118 Citations (Scopus)
  • Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-β delineate two distinct groups of children with brain tumors

    Sandén, E., Enríquez Pérez, J., Visse, E., Kool, M., Carén, H., Siesjö, P. & Darabi, A., 1 Dec 2016, In: Pediatric Blood and Cancer. 63, 12, p. 2112-2122 11 p.

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)
  • Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

    Thompson, E. M., Hielscher, T., Bouffet, E., Remke, M., Luu, B., Gururangan, S., McLendon, R. E., Bigner, D. D., Lipp, E. S., Perreault, S., Cho, Y. J., Grant, G., Kim, S. K., Lee, J. Y., Rao, A. A. N., Giannini, C., Li, K. K. W., Ng, H. K., Yao, Y., Kumabe, T., & 87 othersTominaga, T., Grajkowska, W. A., Perek-Polnik, M., Low, D. C. Y., Seow, W. T., Chang, K. T. E., Mora, J., Pollack, I. F., Hamilton, R. L., Leary, S., Moore, A. S., Ingram, W. J., Hallahan, A. R., Jouvet, A., Fèvre-Montange, M., Vasiljevic, A., Faure-Conter, C., Shofuda, T., Kagawa, N., Hashimoto, N., Jabado, N., Weil, A. G., Gayden, T., Wataya, T., Shalaby, T., Grotzer, M., Zitterbart, K., Sterba, J., Kren, L., Hortobágyi, T., Klekner, A., László, B., Pócza, T., Hauser, P., Schüller, U., Jung, S., Jang, W. Y., French, P. J., Kros, J. M., van Veelen, M. L. C., Massimi, L., Leonard, J. R., Rubin, J. B., Vibhakar, R., Chambless, L. B., Cooper, M. K., Thompson, R. C., Faria, C. C., Carvalho, A., Nunes, S., Pimentel, J., Fan, X., Muraszko, K. M., López-Aguilar, E., Lyden, D., Garzia, L., Shih, D. J. H., Kijima, N., Schneider, C., Adamski, J., Northcott, P. A., Kool, M., Jones, D. T. W., Chan, J. A., Nikolic, A., Garre, M. L., Van Meir, E. G., Osuka, S., Olson, J. J., Jahangiri, A., Castro, B. A., Gupta, N., Weiss, W. A., Moxon-Emre, I., Mabbott, D. J., Lassaletta, A., Hawkins, C. E., Tabori, U., Drake, J., Kulkarni, A., Dirks, P., Rutka, J. T., Korshunov, A., Pfister, S. M., Packer, R. J., Ramaswamy, V. & Taylor, M. D., 1 Apr 2016, In: The Lancet Oncology. 17, 4, p. 484-495 12 p.

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    243 Citations (Scopus)
  • Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

    for the International Cancer Genome Consortium PedBrain Tumor Project, 1 Nov 2016, In: Nature Medicine. 22, 11, p. 1314-1320 7 p.

    Research output: Contribution to journalArticlepeer-review

    162 Citations (Scopus)
  • Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

    Ramaswamy, V., Remke, M., Bouffet, E., Bailey, S., Clifford, S. C., Doz, F., Kool, M., Dufour, C., Vassal, G., Milde, T., Witt, O., von Hoff, K., Pietsch, T., Northcott, P. A., Gajjar, A., Robinson, G. W., Padovani, L., André, N., Massimino, M., Pizer, B., & 5 othersPacker, R., Rutkowski, S., Pfister, S. M., Taylor, M. D. & Pomeroy, S. L., 1 Jun 2016, In: Acta Neuropathologica. 131, 6, p. 821-831 11 p.

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    423 Citations (Scopus)
  • Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas

    Sahm, F., Jakobiec, F. A., Meyer, J., Schrimpf, D., Eberhart, C. G., Hovestadt, V., Capper, D., Lambo, S., Ryzhova, M., Schüller, U., Zheludkova, O., Kumirova, E., Lichter, P., von Deimling, A., Jones, D. T. W., Pfister, S. M., Kool, M. & Korshunov, A., 1 May 2016, In: Genes Chromosomes and Cancer. 55, 5, p. 418-427 10 p.

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    30 Citations (Scopus)
  • Telomere dysfunction and chromothripsis

    Ernst, A., Jones, D. T. W., Maass, K. K., Rode, A., Deeg, K. I., Jebaraj, B. M. C., Korshunov, A., Hovestadt, V., Tainsky, M. A., Pajtler, K. W., Bender, S., Brabetz, S., Gröbner, S., Kool, M., Devens, F., Edelmann, J., Zhang, C., Castelo-Branco, P., Tabori, U., Malkin, D., & 5 othersRippe, K., Stilgenbauer, S., Pfister, S. M., Zapatka, M. & Lichter, P., 15 Jun 2016, In: International Journal of Cancer. 138, 12, p. 2905-2914 10 p.

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    38 Citations (Scopus)