Marcel Kool

Calculated based on number of publications stored in Pure and citations from Scopus
1997 …2023

Research activity per year

If you made any changes in Pure these will be visible here soon.

Search results

  • 2016

    Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis

    Ramaswamy, V., Hielscher, T., Mack, S. C., Lassaletta, A., Lin, T., Pajtler, K. W., Jones, D. T. W., Luu, B., Cavalli, F. M. G., Aldape, K., Remke, M., Mynarek, M., Rutkowski, S., Gururangan, S., McLendon, R. E., Lipp, E. S., Dunham, C., Hukin, J., Eisenstat, D. D., Fulton, D., & 95 othersVan Landeghem, F. K. H., Santi, M., Van Veelen, M. L. C., Van Meir, E. G., Osuka, S., Fan, X., Muraszko, K. M., Tirapelli, D. P. C., Oba-Shinjo, S. M., Marie, S. K. N., Carlotti, C. G., Lee, J. Y., Rao, A. A. N., Giannini, C., Faria, C. C., Nunes, S., Mora, J., Hamilton, R. L., Hauser, P., Jabado, N., Petrecca, K., Jung, S., Massimi, L., Zollo, M., Cinalli, G., Bognár, L., Klekner, A., Hortobágyi, T., Leary, S., Ermoian, R. P., Olson, J. M., Leonard, J. R., Gardner, C., Grajkowska, W. A., Chambless, L. B., Cain, J., Eberhart, C. G., Ahsan, S., Massimino, M., Giangaspero, F., Buttarelli, F. R., Packer, R. J., Emery, L., Yong, W. H., Soto, H., Liau, L. M., Everson, R., Grossbach, A., Shalaby, T., Grotzer, M., Karajannis, M. A., Zagzag, D., Wheeler, H., Von Hoff, K., Alonso, M. M., Tuñon, T., Schüller, U., Zitterbart, K., Sterba, J., Chan, J. A., Guzman, M., Elbabaa, S. K., Colman, H., Dhall, G., Fisher, P. G., Fouladi, M., Gajjar, A., Goldman, S., Hwang, E., Kool, M., Ladha, H., Vera-Bolanos, E., Wani, K., Lieberman, F., Mikkelsen, T., Omuro, A. M., Pollack, I. F., Prados, M., Robins, H. I., Soffietti, R., Wu, J., Metellus, P., Tabori, U., Bartels, U., Bouffet, E., Hawkins, C. E., Rutka, J. T., Dirks, P., Pfister, S. M., Merchant, T. E., Gilbert, M. R., Armstrong, T. S., Korshunov, A., Ellison, D. W. & Taylor, M. D., 20 Jul 2016, In: Journal of Clinical Oncology. 34, 21, p. 2468-2477 10 p.

    Research output: Contribution to journalArticlepeer-review

    150 Citations (Scopus)
  • Tissue factor regulation by miR-520g in primitive neuronal brain tumor cells A possible link between oncomirs and the vascular tumor microenvironment

    D'Asti, E., Huang, A., Kool, M., Meehan, B., Chan, J. A., Jabado, N., Korshunov, A., Pfister, S. M. & Rak, J., 1 Feb 2016, In: American Journal of Pathology. 186, 2, p. 446-459 14 p.

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)
  • Treatment of children and adolescents with metastatic medulloblastoma and prognostic relevance of clinical and biologic parameters

    Von Bueren, A. O., Kortmann, R. D., Von Hoff, K., Friedrich, C., Mynarek, M., Müller, K., Goschzik, T., Zur Mühlen, A., Gerber, N., Warmuth-Metz, M., Soerensen, N., Deinlein, F., Benesch, M., Zwiener, I., Kwiecien, R., Faldum, A., Bode, U., Fleischhack, G., Hovestadt, V., Kool, M., & 6 othersJones, D., Northcott, P., Kuehl, J., Pfister, S., Pietsch, T. & Rutkowski, S., 1 Dec 2016, In: Journal of Clinical Oncology. 34, 34, p. 4151-4160 10 p.

    Research output: Contribution to journalArticlepeer-review

    109 Citations (Scopus)
  • 2015

    Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas

    Sandén, E., Dyberg, C., Krona, C., Visse, E., Carén, H., Northcott, P. A., Kool, M., Ståhl, N., Persson, A., Englund, E., Johnsen, J. I., Siesjö, P. & Darabi, A., 26 May 2015, In: Journal of Neuro-Oncology. 123, 1, p. 1-13 13 p.

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)
  • Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines

    Unland, R., Borchardt, C., Clemens, D., Kool, M., Dirksen, U. & Frühwald, M. C., Mar 2015, In: Anti-Cancer Drugs. 26, 3, p. 301-311 11 p.

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)
  • A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

    Giachino, C., Boulay, J. L., Ivanek, R., Alvarado, A., Tostado, C., Lugert, S., Tchorz, J., Coban, M., Mariani, L., Bettler, B., Lathia, J., Frank, S., Pfister, S., Kool, M. & Taylor, V., 14 Dec 2015, In: Cancer Cell. 28, 6, p. 730-742 13 p.

    Research output: Contribution to journalArticlepeer-review

    72 Citations (Scopus)
  • Brain tumor epidemiology - A hub within multidisciplinary neuro-oncology. report on the 15th brain tumor epidemiology consortium (BTEC) annual meeting, Vienna, 2014

    Brain Tumor Epidemiology Consortium, 2015, In: Clinical Neuropathology. 34, 1, p. 40-46 7 p.

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)
  • Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

    Korshunov, A., Jakobiec, F. A., Eberhart, C. G., Hovestadt, V., Capper, D., Jones, D. T. W., Sturm, D., Stagner, A. M., Edward, D. P., Eagle, R. C., Proia, A. D., Koch, A., Ryzhova, M., Ektova, A., Schüller, U., Zheludkova, O., Lichter, P., von Deimling, A., Pfister, S. M. & Kool, M., 1 Dec 2015, In: Neuropathology. 35, 6, p. 538-544 7 p.

    Research output: Contribution to journalArticlepeer-review

    34 Citations (Scopus)
  • Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma

    Faria, C. C., Golbourn, B. J., Dubuc, A. M., Remke, M., Diaz, R. J., Agnihotri, S., Luck, A., Sabha, N., Olsen, S., Wu, X., Garzia, L., Ramaswamy, V., Mack, S. C., Wang, X., Leadley, M., Reynaud, D., Ermini, L., Post, M., Northcott, P. A., Pfister, S. M., & 6 othersCroul, S. E., Kool, M., Korshunov, A., Smith, C. A., Taylor, M. D. & Rutka, J. T., 1 Jan 2015, In: Cancer Research. 75, 1, p. 134-146 13 p.

    Research output: Contribution to journalArticlepeer-review

    49 Citations (Scopus)
  • Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

    Korshunov, A., Ryzhova, M., Hovestadt, V., Bender, S., Sturm, D., Capper, D., Meyer, J., Schrimpf, D., Kool, M., Northcott, P. A., Zheludkova, O., Milde, T., Witt, O., Kulozik, A. E., Reifenberger, G., Jabado, N., Perry, A., Lichter, P., von Deimling, A., Pfister, S. M., & 1 othersJones, D. T. W., 1 May 2015, In: Acta Neuropathologica. 129, 5, p. 669-678 10 p.

    Research output: Contribution to journalArticlepeer-review

    249 Citations (Scopus)
  • Intraocular medulloepitheliomas and embryonal tumors with multilayered rosettes of the brain: Comparative roles of LIN28A and C19MC

    Jakobiec, F. A., Kool, M., Stagner, A. M., Pfister, S. M., Eagle, R. C., Proia, A. D. & Korshunov, A., 1 Jun 2015, In: American Journal of Ophthalmology. 159, 6, p. 1065-1074.e1

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)
  • Knockdown of ephb1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization

    Bhatia, S., Baig, N. A., Timofeeva, O., Pasquale, E. B., Hirsch, K., MacDonald, T. J., Dritschilo, A., Lee, Y. C., Henkemeyer, M., Rood, B., Jung, M., Wang, X. J., Kool, M., Rodriguez, O., Albanese, C. & Karam, S. D., 2015, In: Oncotarget. 6, 11, p. 8929-8946 18 p.

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)
  • Long-term survival in a case of ETANTR with histological features of neuronal maturation after therapy

    Antonelli, M., Korshunov, A., Mastronuzzi, A., Diomedi Camassei, F., Carai, A., Colafati, G. S., Pfister, S. M., Kool, M. & Giangaspero, F., 1 May 2015, In: Virchows Archiv. 466, 5, p. 603-607 5 p.

    Research output: Contribution to journalReview articlepeer-review

    17 Citations (Scopus)
  • Medulloepithelioma with peculiar clinical presentation, stem cell phenotype and aberrant DNA-methylation profile

    Ozolek, J. A., Cohen, D. E., Kool, M., Pfister, S. M., Korshunov, A., Bukowinski, A. J. & Davis, A. W., 2015, In: CNS oncology. 4, 4, p. 203-212 10 p.

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)
  • Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

    Pajtler, K. W., Witt, H., Sill, M., Jones, D. T. W., Hovestadt, V., Kratochwil, F., Wani, K., Tatevossian, R., Punchihewa, C., Johann, P., Reimand, J., Warnatz, H. J., Ryzhova, M., Mack, S., Ramaswamy, V., Capper, D., Schweizer, L., Sieber, L., Wittmann, A., Huang, Z., & 36 othersvan Sluis, P., Volckmann, R., Koster, J., Versteeg, R., Fults, D., Toledano, H., Avigad, S., Hoffman, L. M., Donson, A. M., Foreman, N., Hewer, E., Zitterbart, K., Gilbert, M., Armstrong, T. S., Gupta, N., Allen, J. C., Karajannis, M. A., Zagzag, D., Hasselblatt, M., Kulozik, A. E., Witt, O., Collins, V. P., von Hoff, K., Rutkowski, S., Pietsch, T., Bader, G., Yaspo, M. L., von Deimling, A., Lichter, P., Taylor, M. D., Gilbertson, R., Ellison, D. W., Aldape, K., Korshunov, A., Kool, M. & Pfister, S. M., 11 May 2015, In: Cancer Cell. 27, 5, p. 728-743 16 p.

    Research output: Contribution to journalArticlepeer-review

    811 Citations (Scopus)
  • Molecular dissection of ependymomas

    Pajtler, K. W., Pfister, S. M. & Kool, M., 2015, In: Oncoscience. 2, 10, p. 827-828 2 p.

    Research output: Contribution to journalEditorial

    15 Citations (Scopus)
  • Multiple mechanisms of MYCN dysregulation in Wilms tumour

    Williams, R. D., Chagtai, T., Alcaide-German, M., Apps, J., Wegert, J., Popov, S., Vujanic, G., Harm van Tinteren, V. T., van den Heuvel-Eibrink, M. M., Kool, M., Jan de Kraker, D. K., Gisselsson, D., Graf, N., Gessler, M. & Pritchard-Jones, K., 2015, In: Oncotarget. 6, 9, p. 7232-7243 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    78 Citations (Scopus)
  • Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

    Wegert, J., Ishaque, N., Vardapour, R., Geörg, C., Gu, Z., Bieg, M., Ziegler, B., Bausenwein, S., Nourkami, N., Ludwig, N., Keller, A., Grimm, C., Kneitz, S., Williams, R. D., Chagtai, T., Pritchard-Jones, K., vanSluis, P., Volckmann, R., Koster, J., Versteeg, R., & 15 othersAcha, T., O'Sullivan, M. J., Bode, P. K., Niggli, F., Tytgat, G. A., vanTinteren, H., vandenHeuvel-Eibrink, M. M., Meese, E., Vokuhl, C., Leuschner, I., Graf, N., Eils, R., Pfister, S. M., Kool, M. & Gessler, M., 9 Feb 2015, In: Cancer Cell. 27, 2, p. 298-311 14 p.

    Research output: Contribution to journalArticlepeer-review

    213 Citations (Scopus)
  • Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age

    Fontebasso, A. M., Shirinian, M., Khuong-Quang, D. A., Bechet, D., Gayden, T., Kool, M., De Jay, N., Jacob, K., Gerges, N., Hutter, B., Seker-Cin, H., Witt, H., Montpetit, A., Brunet, S., Lepage, P., Bourret, G., Klekner, A., Bognár, L., Hauser, P., Garami, M., & 15 othersFarmer, J. P., Montes, J. L., Atkinson, J., Lambert, S., Kwan, T., Korshunov, A., Tabori, U., Peter Collins, V., Albrecht, S., Faury, D., Pfister, S. M., Paulus, W., Hasselblatt, M., Jones, D. T. W. & Jabado, N., 2015, In: Oncotarget. 6, 31, p. 31844-31856 13 p.

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)
  • Serpine2/PN-1 is required for proliferative expansion of pre-neoplastic lesions and malignant progression to medulloblastoma

    Vaillant, C., Valdivieso, P., Nuciforo, S., Kool, M., Schwarzentruber-Schauerte, A., Méreau, H., Cabuy, E., Lobrinus, J. A., Pfister, S., Zuniga, A., Frank, S. & Zeller, R., 22 Apr 2015, In: PLoS ONE. 10, 4, e0124870.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    23 Citations (Scopus)
  • Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

    Ecker, J., Oehme, I., Mazitschek, R., Korshunov, A., Kool, M., Hielscher, T., Kiss, J., Selt, F., Konrad, C., Lodrini, M., Deubzer, H. E., von Deimling, A., Kulozik, A. E., Pfister, S. M., Witt, O. & Milde, T., 3 Apr 2015, In: Acta neuropathologica communications. 3, p. 22 1 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    66 Citations (Scopus)
  • The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants

    Buss, M. C., Remke, M., Lee, J., Gandhi, K., Schniederjan, M. J., Kool, M., Northcott, P. A., Pfister, S. M., Taylor, M. D. & Castellino, R. C., 26 Feb 2015, In: Oncogene. 34, 9, p. 1126-1140 15 p.

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)
  • Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

    Wickström, M., Dyberg, C., Milosevic, J., Einvik, C., Calero, R., Sveinbjörnsson, B., Sandén, E., Darabi, A., Siesjö, P., Kool, M., Kogner, P., Baryawno, N. & Johnsen, J. I., 25 Nov 2015, In: Nature Communications. 6, 8904.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    163 Citations (Scopus)
  • 2014

    Arhgap36-dependent activation of Gli transcription factors

    Rack, P. G., Ni, J., Payumo, A. Y., Nguyen, V., Crapster, J. A., Hovestadt, V., Kool, M., Jones, D. T. W., Mich, J. K., Firestone, A. J., Pfister, S. M., Cho, Y. J. & Chen, J. K., 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 30, p. 11061-11066 6 p.

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)
  • Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1

    Kerl, K., Moreno, N., Holsten, T., Ahlfeld, J., Mertins, J., Hotfilder, M., Kool, M., Bartelheim, K., Schleicher, S., Handgretinger, R., Schüller, U., Meisterernst, M. & Frühwald, M. C., 15 Aug 2014, In: International Journal of Cancer. 135, 4, p. 989-995 7 p.

    Research output: Contribution to journalArticlepeer-review

    41 Citations (Scopus)
  • Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: Evidence for growth factor-thrombin cross-talk

    D'Asti, E., Kool, M., Pfister, S. M. & Rak, J., 1 Nov 2014, In: Journal of Thrombosis and Haemostasis. 12, 11, p. 1838-1849 12 p.

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)
  • Cytogenetic prognostication within medulloblastoma subgroups

    Shih, D. J. H., Northcott, P. A., Remke, M., Korshunov, A., Ramaswamy, V., Kool, M., Luu, B., Yao, Y., Wang, X., Dubuc, A. M., Garzia, L., Peacock, J., Mack, S. C., Wu, X., Rolider, A., Morrissy, A. S., Cavalli, F. M. G., Jones, D. T. W., Zitterbart, K., Faria, C. C., & 73 othersSchüller, U., Kren, L., Kumabe, T., Tominaga, T., Ra, Y. S., Garami, M., Hauser, P., Chan, J. A., Robinson, S., Bognár, L., Klekner, A., Saad, A. G., Liau, L. M., Albrecht, S., Fontebasso, A., Cinalli, G., De Antonellis, P., Zollo, M., Cooper, M. K., Thompson, R. C., Bailey, S., Lindsey, J. C., Di Rocco, C., Massimi, L., Michiels, E. M. C., Scherer, S. W., Phillips, J. J., Gupta, N., Fan, X., Muraszko, K. M., Vibhakar, R., Eberhart, C. G., Fouladi, M., Lach, B., Jung, S., Wechsler-Reya, R. J., Fèvre-Montange, M., Jouvet, A., Jabado, N., Pollack, I. F., Weiss, W. A., Lee, J. Y., Cho, B. K., Kim, S. K., Wang, K. C., Leonard, J. R., Rubin, J. B., De Torres, C., Lavarino, C., Mora, J., Cho, Y. J., Tabori, U., Olson, J. M., Gajjar, A., Packer, R. J., Rutkowski, S., Pomeroy, S. L., French, P. J., Kloosterhof, N. K., Kros, J. M., Van Meir, E. G., Clifford, S. C., Bourdeaut, F., Delattre, O., Doz, F. F., Hawkins, C. E., Malkin, D., Grajkowska, W. A., Perek-Polnik, M., Bouffet, E., Rutka, J. T., Pfister, S. M. & Taylor, M. D., 20 Mar 2014, In: Journal of Clinical Oncology. 32, 9, p. 886-896 11 p.

    Research output: Contribution to journalArticlepeer-review

    233 Citations (Scopus)
  • Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

    Hovestadt, V., Jones, D. T. W., Picelli, S., Wang, W., Kool, M., Northcott, P. A., Sultan, M., Stachurski, K., Ryzhova, M., Warnatz, H. J., Ralser, M., Brun, S., Bunt, J., Jäger, N., Kleinheinz, K., Erkek, S., Weber, U. D., Bartholomae, C. C., Von Kalle, C., Lawerenz, C., & 25 othersEils, J., Koster, J., Versteeg, R., Milde, T., Witt, O., Schmidt, S., Wolf, S., Pietsch, T., Rutkowski, S., Scheurlen, W., Taylor, M. D., Brors, B., Felsberg, J., Reifenberger, G., Borkhardt, A., Lehrach, H., Wechsler-Reya, R. J., Eils, R., Yaspo, M. L., Landgraf, P., Korshunov, A., Zapatka, M., Radlwimmer, B., Pfister, S. M. & Lichter, P., 2014, In: Nature. 510, 7506, p. 537-541 5 p.

    Research output: Contribution to journalArticlepeer-review

    324 Citations (Scopus)
  • Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

    Korshunov, A., Sturm, D., Ryzhova, M., Hovestadt, V., Gessi, M., Jones, D. T. W., Remke, M., Northcott, P., Perry, A., Picard, D., Rosenblum, M., Antonelli, M., Aronica, E., Schüller, U., Hasselblatt, M., Woehrer, A., Zheludkova, O., Kumirova, E., Puget, S., Taylor, M. D., & 8 othersGiangaspero, F., Peter Collins, V., Von Deimling, A., Lichter, P., Huang, A., Pietsch, T., Pfister, S. M. & Kool, M., Aug 2014, In: Acta Neuropathologica. 128, 2, p. 279-289 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    165 Citations (Scopus)
  • Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

    Northcott, P. A., Lee, C., Zichner, T., Stütz, A. M., Erkek, S., Kawauchi, D., Shih, D. J. H., Hovestadt, V., Zapatka, M., Sturm, D., Jones, D. T. W., Kool, M., Remke, M., Cavalli, F. M. G., Zuyderduyn, S., Bader, G. D., Vandenberg, S., Esparza, L. A., Ryzhova, M., Wang, W., & 59 othersWittmann, A., Stark, S., Sieber, L., Seker-Cin, H., Linke, L., Kratochwil, F., Jäger, N., Buchhalter, I., Imbusch, C. D., Zipprich, G., Raeder, B., Schmidt, S., Diessl, N., Wolf, S., Wiemann, S., Brors, B., Lawerenz, C., Eils, J., Warnatz, H. J., Risch, T., Yaspo, M. L., Weber, U. D., Bartholomae, C. C., Von Kalle, C., Turányi, E., Hauser, P., Sanden, E., Darabi, A., Siesjö, P., Sterba, J., Zitterbart, K., Sumerauer, D., Van Sluis, P., Versteeg, R., Volckmann, R., Koster, J., Schuhmann, M. U., Ebinger, M., Grimes, H. L., Robinson, G. W., Gajjar, A., Mynarek, M., Von Hoff, K., Rutkowski, S., Pietsch, T., Scheurlen, W., Felsberg, J., Reifenberger, G., Kulozik, A. E., Von Deimling, A., Witt, O., Eils, R., Gilbertson, R. J., Korshunov, A., Taylor, M. D., Lichter, P., Korbel, J. O., Wechsler-Reya, R. J. & Pfister, S. M., 2014, In: Nature. 511, 7510, p. 428-434 7 p.

    Research output: Contribution to journalArticlepeer-review

    453 Citations (Scopus)
  • Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

    MacK, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stütz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jäger, N., Jones, D. T. W., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J. H., Head, R., & 69 othersRemke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, L., Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., Von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A. & Taylor, M. D., 2014, In: Nature. 506, 7489, p. 445-450 6 p.

    Research output: Contribution to journalArticlepeer-review

    461 Citations (Scopus)
  • Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

    Kool, M., Jones, D. T. W., Jäger, N., Northcott, P. A., Pugh, T. J., Hovestadt, V., Piro, R. M., Esparza, L. A., Markant, S. L., Remke, M., Milde, T., Bourdeaut, F., Ryzhova, M., Sturm, D., Pfaff, E., Stark, S., Hutter, S., Sxeker-Cin, H., Johann, P., Bender, S., & 56 othersSchmidt, C., Rausch, T., Shih, D., Reimand, J., Sieber, L., Wittmann, A., Linke, L., Witt, H., Weber, U. D., Zapatka, M., König, R., Beroukhim, R., Bergthold, G., Van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., Schmidt, S., Wolf, S., Lawerenz, C., Bartholomae, C. C., Von Kalle, C., Unterberg, A., Herold-Mende, C., Hofer, S., Kulozik, A. E., Von Deimling, A., Scheurlen, W., Felsberg, J., Reifenberger, G., Hasselblatt, M., Crawford, J. R., Grant, G. A., Jabado, N., Perry, A., Cowdrey, C., Croul, S., Zadeh, G., Korbel, J. O., Doz, F., Delattre, O., Bader, G. D., McCabe, M. G., Collins, V. P., Kieran, M. W., Cho, Y. J., Pomeroy, S. L., Witt, O., Brors, B., Taylor, M. D., Schüller, U., Korshunov, A., Eils, R., Wechsler-Reya, R. J., Lichter, P. & Pfister, S. M., 17 Mar 2014, In: Cancer Cell. 25, 3, p. 393-405 13 p.

    Research output: Contribution to journalArticlepeer-review

    579 Citations (Scopus)
  • Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts

    Pöschl, J., Stark, S., Neumann, P., Gröbner, S., Kawauchi, D., Jones, D. T. W., Northcott, P. A., Lichter, P., Pfister, S. M., Kool, M. & Schüller, U., Jul 2014, In: Acta Neuropathologica. 128, 1, p. 123-136 14 p.

    Research output: Contribution to journalArticlepeer-review

    53 Citations (Scopus)
  • Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster

    Jeibmann, A., Eikmeier, K., Linge, A., Kool, M., Koos, B., Schulz, J., Albrecht, S., Bartelheim, K., Frühwald, M. C., Pfister, S. M., Paulus, W. & Hasselblatt, M., 3 Jun 2014, In: Nature Communications. 5, 4005.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    18 Citations (Scopus)
  • Loss of Smarc proteins impairs cerebellar development

    Moreno, N., Schmidt, C., Ahlfeld, J., Pöschl, J., Dittmar, S., Pfister, S. M., Kool, M., Kerl, K. & Schüller, U., 1 Oct 2014, In: Journal of Neuroscience. 34, 40, p. 13486-13491 6 p.

    Research output: Contribution to journalArticlepeer-review

    34 Citations (Scopus)
  • Medulloblastoma Down under 2013: A report from the third annual meeting of the International Medulloblastoma Working Group

    Gottardo, N. G., Hansford, J. R., McGlade, J. P., Alvaro, F., Ashley, D. M., Bailey, S., Baker, D. L., Bourdeaut, F., Cho, Y. J., Clay, M., Clifford, S. C., Cohn, R. J., Cole, C. H., Dallas, P. B., Downie, P., Doz, F., Ellison, D. W., Endersby, R., Fisher, P. G., Hassall, T., & 31 othersHeath, J. A., Hii, H. L., Jones, D. T. W., Junckerstorff, R., Kellie, S., Kool, M., Kotecha, R. S., Lichter, P., Laughton, S. J., Lee, S., McCowage, G., Northcott, P. A., Olson, J. M., Packer, R. J., Pfister, S. M., Pietsch, T., Pizer, B., Pomeroy, S. L., Remke, M., Robinson, G. W., Rutkowski, S., Schoep, T., Shelat, A. A., Stewart, C. F., Sullivan, M., Taylor, M. D., Wainwright, B., Walwyn, T., Weiss, W. A., Williamson, D. & Gajjar, A., Feb 2014, In: Acta Neuropathologica. 127, 2, p. 189-201 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    91 Citations (Scopus)
  • Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progression

    Milla, L. A., Arros, A., Espinoza, N., Remke, M., Kool, M., Taylor, M. D., Pfister, S. M., Wainwright, B. J. & Palma, V., 1 Jan 2014, In: International Journal of Cancer. 134, 1, p. 21-31 11 p.

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)
  • PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas

    Erdreich-Epstein, A., Robison, N., Ren, X., Zhou, H., Xu, J., Davidson, T. B., Schur, M., Gilles, F. H., Ji, L., Malvar, J., Shackleford, G. M., Margol, A. S., Krieger, M. D., Judkins, A. R., Jones, D. T. W., Pfister, S. M., Kool, M., Sposto, R. & Asgharazadeh, S., 2014, In: Clinical Cancer Research. 20, 4, p. 827-836 10 p.

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)
  • Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

    Pietsch, T., Schmidt, R., Remke, M., Korshunov, A., Hovestadt, V., Jones, D. T. W., Felsberg, J., Kaulich, K., Goschzik, T., Kool, M., Northcott, P. A., Von Hoff, K., Von Bueren, A. O., Friedrich, C., Mynarek, M., Skladny, H., Fleischhack, G., Taylor, M. D., Cremer, F., Lichter, P., & 4 othersFaldum, A., Reifenberger, G., Rutkowski, S. & Pfister, S. M., Jul 2014, In: Acta Neuropathologica. 128, 1, p. 137-149 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    115 Citations (Scopus)
  • Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

    Vanner, R. J., Remke, M., Gallo, M., Selvadurai, H. J., Coutinho, F., Lee, L., Kushida, M., Head, R., Morrissy, S., Zhu, X., Aviv, T., Voisin, V., Clarke, I. D., Li, Y., Mungall, A. J., Moore, R. A., Ma, Y., Jones, S. J. M., Marra, M. A., Malkin, D., & 8 othersNorthcott, P. A., Kool, M., Pfister, S. M., Bader, G., Hochedlinger, K., Korshunov, A., Taylor, M. D. & Dirks, P. B., 14 Jul 2014, In: Cancer Cell. 26, 1, p. 33-47 15 p.

    Research output: Contribution to journalArticlepeer-review

    214 Citations (Scopus)
  • Subgroup-specific localization of human medulloblastoma based on pre-operative MRI

    Wefers, A. K., Warmuth-Metz, M., Pöschl, J., von Bueren, A. O., Monoranu, C-M., Seelos, K., Peraud, A., Tonn, J-C., Koch, A., Pietsch, T., Herold-Mende, C., Mawrin, C., Schouten-van Meeteren, A., van Vuurden, D., von Hoff, K., Rutkowski, S., Pfister, S. M., Kool, M. & Schüller, U., Apr 2014, In: Acta Neuropathologica. 127, 6, p. 931-3 3 p.

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)
  • The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

    He, X., Zhang, L., Chen, Y., Remke, M., Shih, D., Lu, F., Wang, H., Deng, Y., Yu, Y., Xia, Y., Wu, X., Ramaswamy, V., Hu, T., Wang, F., Zhou, W., Burns, D. K., Kim, S. H., Kool, M., Pfister, S. M., Weinstein, L. S., & 7 othersPomeroy, S. L., Gilbertson, R. J., Rubin, J. B., Hou, Y., Wechsler-Reya, R., Taylor, M. D. & Lu, Q. R., 1 Sept 2014, In: Nature Medicine. 20, 9, p. 1035-1042 8 p.

    Research output: Contribution to journalArticlepeer-review

    99 Citations (Scopus)
  • The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors

    Mille, F., Tamayo-Orrego, L., Lévesque, M., Remke, M., Korshunov, A., Cardin, J., Bouchard, N., Izzi, L., Kool, M., Northcott, P. A., Taylor, M. D., Pfister, S. M. & Charron, F., 13 Oct 2014, In: Developmental Cell. 31, 1, p. 34-47 14 p.

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)
  • Transitioning from genotypes to epigenotypes: Why the time has come for medulloblastoma epigenomics

    Batora, N. V., Sturm, D., Jones, D. T. W., Kool, M., Pfister, S. M. & Northcott, P. A., 4 Apr 2014, In: Neuroscience. 264, p. 171-185 15 p.

    Research output: Contribution to journalReview articlepeer-review

    37 Citations (Scopus)
  • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

    Zhukova, N., Ramaswamy, V., Remke, M., Martin, D. C., Castelo-Branco, P., Zhang, C. H., Fraser, M., Tse, K., Poon, R., Shih, D. J. H., Baskin, B., Ray, P. N., Bouffet, E., Dirks, P., von Bueren, A. O., Pfaff, E., Korshunov, A., Jones, D. T. W., Northcott, P. A., Kool, M., & 40 othersPugh, T. J., Pomeroy, S. L., Cho, Y. J., Pietsch, T., Gessi, M., Rutkowski, S., Bognár, L., Cho, B. K., Eberhart, C. G., Conter, C. F., Fouladi, M., French, P. J., Grajkowska, W. A., Gupta, N., Hauser, P., Jabado, N., Vasiljevic, A., Jung, S., Kim, S. K., Klekner, A., Kumabe, T., Lach, B., Leonard, J. R., Liau, L. M., Massimi, L., Pollack, I. F., Ra, Y. S., Rubin, J. B., Van Meir, E. G., Wang, K. C., Weiss, W. A., Zitterbart, K., Bristow, R. G., Alman, B., Hawkins, C. E., Malkin, D., Clifford, S. C., Pfister, S. M., Taylor, M. D. & Tabori, U., 27 Jan 2014, In: Acta neuropathologica communications. 2, 1, 174.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    35 Citations (Scopus)
  • 2013

    Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma

    Dubuc, A. M., Remke, M., Korshunov, A., Northcott, P. A., Zhan, S. H., Mendez-Lago, M., Kool, M., Jones, D. T. W., Unterberger, A., Morrissy, A. S., Shih, D., Peacock, J., Ramaswamy, V., Rolider, A., Wang, X., Witt, H., Hielscher, T., Hawkins, C., Vibhakar, R., Croul, S., & 7 othersRutka, J. T., Weiss, W. A., Jones, S. J. M., Eberhart, C. G., Marra, M. A., Pfister, S. M. & Taylor, M. D., Mar 2013, In: Acta Neuropathologica. 125, 3, p. 373-384 12 p.

    Research output: Contribution to journalArticlepeer-review

    139 Citations (Scopus)
  • BAF complexes facilitate decatenation of DNA by topoisomerase IIα

    Dykhuizen, E. C., Hargreaves, D. C., Miller, E. L., Cui, K., Korshunov, A., Kool, M., Pfister, S., Cho, Y. J., Zhao, K. & Crabtree, G. R., 30 May 2013, In: Nature. 497, 7451, p. 624-627 4 p.

    Research output: Contribution to journalArticlepeer-review

    197 Citations (Scopus)
  • Coverage Bias and Sensitivity of Variant Calling for Four Whole-genome Sequencing Technologies

    Rieber, N., Zapatka, M., Lasitschka, B., Jones, D., Northcott, P., Hutter, B., Jäger, N., Kool, M., Taylor, M., Lichter, P., Pfister, S., Wolf, S., Brors, B. & Eils, R., 11 Jun 2013, In: PLoS ONE. 8, 6, e66621.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    67 Citations (Scopus)
  • Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells

    Spina, R., Filocamo, G., Iaccino, E., Scicchitano, S., Lupia, M., Chiarella, E., Mega, T., Bernaudo, F., Pelaggi, D., Mesuraca, M., Pazzaglia, S., Semenkow, S., Bar, E. E., Kool, M., Pfister, S., Bond, H. M., Eberhart, C. G., Steinkühler, C. & Morrone, G., 2013, In: Oncotarget. 4, 8, p. 1280-1292 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    26 Citations (Scopus)
  • Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma

    Lambert, S. R., Witt, H., Hovestadt, V., Zucknick, M., Kool, M., Pearson, D. M., Korshunov, A., Ryzhova, M., Ichimura, K., Jabado, N., Fontebasso, A. M., Lichter, P., Pfister, S. M., Collins, V. P. & Jones, D. T. W., Aug 2013, In: Acta Neuropathologica. 126, 2, p. 291-301 11 p.

    Research output: Contribution to journalArticlepeer-review

    76 Citations (Scopus)