Marcel Kool

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1997 …2023

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  • 2013

    Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

    Koelsche, C., Sahm, F., Capper, D., Reuss, D., Sturm, D., Jones, D. T. W., Kool, M., Northcott, P. A., Wiestler, B., Bömer, K., Meyer, J., Mawrin, C., Hartmann, C., Mittelbronn, M., Platten, M., Brokinkel, B., Seiz, M., Herold-Mende, C., Unterberg, A., Schittenhelm, J., & 5 othersWeller, M., Pfister, S., Wick, W., Korshunov, A. & Von Deimling, A., Dec 2013, In: Acta Neuropathologica. 126, 6, p. 907-915 9 p.

    Research output: Contribution to journalArticlepeer-review

    248 Citations (Scopus)
  • Epigenetic silencing of DKK3 in medulloblastoma

    Valdora, F., Banelli, B., Stigliani, S., Pfister, S. M., Moretti, S., Kool, M., Remke, M., Bai, A. H. C., Brigati, C., Hielscher, T., Romani, M., Servidei, T., Zollo, M., Cinalli, G., Oberthuer, A., Tonini, G. P. & Coco, S., Apr 2013, In: International Journal of Molecular Sciences. 14, 4, p. 7492-7505 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    18 Citations (Scopus)
  • Erratum: Signatures of mutational processes in human cancer (Nature (2013) 500 (415-421) DOI:10.1038/nature12477)

    Alexandrov, L. B., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., Bignell, G. R., Bolli, N., Borg, A., Børresen-Dale, A. L., Boyault, S., Burkhardt, B., Butler, A. P., Caldas, C., Davies, H. R., Desmedt, C., Eils, R., Eyfjörd, J. E., Foekens, J. A., Greaves, M., & 49 othersHosoda, F., Hutter, B., Ilicic, T., Imbeaud, S., Imielinski, M., Jäger, N., Jones, D. T. W., Knappskog, S., Kool, M., Lakhani, S. R., López-Otín, C., Martin, S., Munshi, N. C., Nakamura, H., Northcott, P. A., Pajic, M., Papaemmanuil, E., Paradiso, A., Pearson, J. V., Puente, X. S., Raine, K., Ramakrishna, M., Richardson, A. L., Richter, J., Rosenstiel, P., Schlesner, M., Schumacher, T. N., Span, P. N., Teague, J. W., Totoki, Y., Tutt, A. N. J., Valdés-Mas, R., Van Buuren, M. M., Van 'T Veer, L., Vincent-Salomon, A., Waddell, N., Yates, L. R., Zucman-Rossi, J., Futreal, P. A., McDermott, U., Lichter, P., Meyerson, M., Grimmond, S. M., Siebert, R., Campo, E., Shibata, T., Pfister, S. M., Campbell, P. J. & Stratton, M. R., 2013, In: Nature. 502, 7470, p. 258 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
    15 Citations (Scopus)
  • Histone deacetylase 10 promotes autophagy-mediated cell survival

    Oehme, I., Linke, J. P., Böck, B. C., Milde, T., Lodrini, M., Hartenstein, B., Wiegand, I., Eckert, C., Roth, W., Kool, M., Kaden, S., Gröne, H. J., Schulte, J. H., Lindner, S., Hamacher-Brady, A., Brady, N. R., Deubzer, H. E. & Witt, O., 9 Jul 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. E2592-E2601

    Research output: Contribution to journalArticlepeer-review

    Open Access
    167 Citations (Scopus)
  • Methylation of the TERT promoter and risk stratification of childhood brain tumours: An integrative genomic and molecular study

    Castelo-Branco, P., Choufani, S., Mack, S., Gallagher, D., Zhang, C., Lipman, T., Zhukova, N., Walker, E. J., Martin, D., Merino, D., Wasserman, J. D., Elizabeth, C., Alon, N., Zhang, L., Hovestadt, V., Kool, M., Jones, D. T. W., Zadeh, G., Croul, S., Hawkins, C., & 9 othersHitzler, J., Wang, J. C. Y., Baruchel, S., Dirks, P. B., Malkin, D., Pfister, S., Taylor, M. D., Weksberg, R. & Tabori, U., May 2013, In: The Lancet Oncology. 14, 6, p. 534-542 9 p.

    Research output: Contribution to journalArticlepeer-review

    200 Citations (Scopus)
  • Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

    Fontebasso, A. M., Schwartzentruber, J., Khuong-Quang, D. A., Liu, X. Y., Sturm, D., Korshunov, A., Jones, D. T. W., Witt, H., Kool, M., Albrecht, S., Fleming, A., Hadjadj, D., Busche, S., Lepage, P., Montpetit, A., Staffa, A., Gerges, N., Zakrzewska, M., Zakrzewski, K., Liberski, P. P., & 9 othersHauser, P., Garami, M., Klekner, A., Bognar, L., Zadeh, G., Faury, D., Pfister, S. M., Jabado, N. & Majewski, J., May 2013, In: Acta Neuropathologica. 125, 5, p. 659-669 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    231 Citations (Scopus)
  • OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels

    Bunt, J., Hasselt, N. A., Zwijnenburg, D. A., Koster, J., Versteeg, R. & Kool, M., Mar 2013, In: Acta Neuropathologica. 125, 3, p. 385-394 10 p.

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)
  • Prognostic value and functional consequences of cell cycle inhibitor p27 Kip1 loss in medulloblastoma

    Hatton, B. A., Ellison, D. W., Gajjar, A., Kool, M., Fero, M. & Olson, J. M., 1 Mar 2013, In: Biomarker Research. 1, 1, 14.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Citations (Scopus)
  • Recurrence patterns across medulloblastoma subgroups: An integrated clinical and molecular analysis

    Ramaswamy, V., Remke, M., Bouffet, E., Faria, C. C., Perreault, S., Cho, Y. J., Shih, D. J., Luu, B., Dubuc, A. M., Northcott, P. A., Schüller, U., Gururangan, S., McLendon, R., Bigner, D., Fouladi, M., Ligon, K. L., Pomeroy, S. L., Dunn, S., Triscott, J., Jabado, N., & 24 othersFontebasso, A., Jones, D. T. W., Kool, M., Karajannis, M. A., Gardner, S. L., Zagzag, D., Nunes, S., Pimentel, J., Mora, J., Lipp, E., Walter, A. W., Ryzhova, M., Zheludkova, O., Kumirova, E., Alshami, J., Croul, S. E., Rutka, J. T., Hawkins, C., Tabori, U., Codispoti, K. E. T., Packer, R. J., Pfister, S. M., Korshunov, A. & Taylor, M. D., Nov 2013, In: The Lancet Oncology. 14, 12, p. 1200-1207 8 p.

    Research output: Contribution to journalArticlepeer-review

    277 Citations (Scopus)
  • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

    Jones, D. T. W., Hutter, B., Jäger, N., Korshunov, A., Kool, M., Warnatz, H. J., Zichner, T., Lambert, S. R., Ryzhova, M., Quang, D. A. K., Fontebasso, A. M., Stütz, A. M., Hutter, S., Zuckermann, M., Sturm, D., Gronych, J., Lasitschka, B., Schmidt, S., Şeker-Cin, H., Witt, H., & 55 othersSultan, M., Ralser, M., Northcott, P. A., Hovestadt, V., Bender, S., Pfaff, E., Stark, S., Faury, D., Schwartzentruber, J., Majewski, J., Weber, U. D., Zapatka, M., Raeder, B., Schlesner, M., Worth, C. L., Bartholomae, C. C., Von Kalle, C., Imbusch, C. D., Radomski, S., Lawerenz, C., Van Sluis, P., Koster, J., Volckmann, R., Versteeg, R., Lehrach, H., Monoranu, C., Winkler, B., Unterberg, A., Mende, C. H., Milde, T., Kulozik, A. E., Ebinger, M., Schuhmann, M. U., Cho, Y. J., Pomeroy, S. L., Von Deimling, A., Witt, O., Taylor, M. D., Wolf, S., Karajannis, M. A., Eberhart, C. G., Scheurlen, W., Hasselblatt, M., Ligon, K. L., Kieran, M. W., Korbel, J. O., Yaspo, M. L., Brors, B., Felsberg, J., Reifenberger, G., Collins, V. P., Jabado, N., Eils, R., Lichter, P. & Pfister, S. M., Aug 2013, In: Nature Genetics. 45, 8, p. 927-932 6 p.

    Research output: Contribution to journalArticlepeer-review

    592 Citations (Scopus)
  • Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

    Bender, S., Tang, Y., Lindroth, A. M., Hovestadt, V., Jones, D. T. W., Kool, M., Zapatka, M., Northcott, P. A., Sturm, D., Wang, W., Radlwimmer, B., Højfeldt, J. W., Truffaux, N., Castel, D., Schubert, S., Ryzhova, M., Şeker-Cin, H., Gronych, J., Johann, P. D., Stark, S., & 21 othersMeyer, J., Milde, T., Schuhmann, M., Ebinger, M., Monoranu, C. M., Ponnuswami, A., Chen, S., Jones, C., Witt, O., Collins, V. P., vonDeimling, A., Jabado, N., Puget, S., Grill, J., Helin, K., Korshunov, A., Lichter, P., Monje, M., Plass, C., Cho, Y. J. & Pfister, S. M., 11 Nov 2013, In: Cancer Cell. 24, 5, p. 660-672 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    544 Citations (Scopus)
  • Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

    Hovestadt, V., Remke, M., Kool, M., Pietsch, T., Northcott, P. A., Fischer, R., Cavalli, F. M. G., Ramaswamy, V., Zapatka, M., Reifenberger, G., Rutkowski, S., Schick, M., Bewerunge-Hudler, M., Korshunov, A., Lichter, P., Taylor, M. D., Pfister, S. M. & Jones, D. T. W., Jun 2013, In: Acta Neuropathologica. 125, 6, p. 913-916 4 p.

    Research output: Contribution to journalLetterpeer-review

    Open Access
    226 Citations (Scopus)
  • Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

    Reuss, D. E., Piro, R. M., Jones, D. T. W., Simon, M., Ketter, R., Kool, M., Becker, A., Sahm, F., Pusch, S., Meyer, J., Hagenlocher, C., Schweizer, L., Capper, D., Kickingereder, P., Mucha, J., Koelsche, C., Jäger, N., Santarius, T., Tarpey, P. S., Stephens, P. J., & 14 othersAndrew Futreal, P., Wellenreuther, R., Kraus, J., Lenartz, D., Herold-Mende, C., Hartmann, C., Mawrin, C., Giese, N., Eils, R., Collins, V. P., König, R., Wiestler, O. D., Pfister, S. M. & Von Deimling, A., Mar 2013, In: Acta Neuropathologica. 125, 3, p. 351-358 8 p.

    Research output: Contribution to journalArticlepeer-review

    192 Citations (Scopus)
  • Somatostatin receptor subtype 2 (sst2) is a potential prognostic marker and a therapeutic target in medulloblastoma

    Remke, M., Hering, E., Gerber, N. U., Kool, M., Sturm, D., Rickert, C. H., Gerß, J., Schulz, S., Hielscher, T., Hasselblatt, M., Jeibmann, A., Hans, V., Ramaswamy, V., Taylor, M. D., Pietsch, T., Rutkowski, S., Korshunov, A., Monoranu, C. M. & Frühwald, M. C., Aug 2013, In: Child's Nervous System. 29, 8, p. 1253-1262 10 p.

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)
  • Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

    Zhukova, N., Ramaswamy, V., Remke, M., Pfaff, E., Shih, D. J. H., Martin, D. C., Castelo-Branco, P., Baskin, B., Ray, P. N., Bouffet, E., Von Bueren, A. O., Jones, D. T. W., Northcott, P. A., Kool, M., Sturm, D., Pugh, T. J., Pomeroy, S. L., Cho, Y. J., Pietsch, T., Gessi, M., & 41 othersRutkowski, S., Bognar, L., Klekner, A., Cho, B. K., Kim, S. K., Wang, K. C., Eberhart, C. G., Fevre-Montange, M., Fouladi, M., French, P. J., Kros, M., Grajkowska, W. A., Gupta, N., Weiss, W. A., Hauser, P., Jabado, N., Jouvet, A., Jung, S., Kumabe, T., Lach, B., Leonard, J. R., Rubin, J. B., Liau, L. M., Massimi, L., Pollack, I. F., Ra, Y. S., Van Meir, E. G., Zitterbart, K., Schüller, U., Hill, R. M., Lindsey, J. C., Schwalbe, E. C., Bailey, S., Ellison, D. W., Hawkins, C., Malkin, D., Clifford, S. C., Korshunov, A., Pfister, S., Taylor, M. D. & Tabori, U., 10 Aug 2013, In: Journal of Clinical Oncology. 31, 23, p. 2927-2935 9 p.

    Research output: Contribution to journalArticlepeer-review

    350 Citations (Scopus)
  • TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

    Remke, M., Ramaswamy, V., Peacock, J., Shih, D. J. H., Koelsche, C., Northcott, P. A., Hill, N., Cavalli, F. M. G., Kool, M., Wang, X., Mack, S. C., Barszczyk, M., Morrissy, A. S., Wu, X., Agnihotri, S., Luu, B., Jones, D. T. W., Garzia, L., Dubuc, A. M., Zhukova, N., & 63 othersVanner, R., Kros, J. M., French, P. J., Van Meir, E. G., Vibhakar, R., Zitterbart, K., Chan, J. A., Bognár, L., Klekner, A., Lach, B., Jung, S., Saad, A. G., Liau, L. M., Albrecht, S., Zollo, M., Cooper, M. K., Thompson, R. C., Delattre, O. O., Bourdeaut, F., Doz, F. F., Garami, M., Hauser, P., Carlotti, C. G., Van Meter, T. E., Massimi, L., Fults, D., Pomeroy, S. L., Kumabe, T., Ra, Y. S., Leonard, J. R., Elbabaa, S. K., Mora, J., Rubin, J. B., Cho, Y. J., McLendon, R. E., Bigner, D. D., Eberhart, C. G., Fouladi, M., Wechsler-Reya, R. J., Faria, C. C., Croul, S. E., Huang, A., Bouffet, E., Hawkins, C. E., Dirks, P. B., Weiss, W. A., Schüller, U., Pollack, I. F., Rutkowski, S., Meyronet, D., Jouvet, A., Fèvre-Montange, M., Jabado, N., Perek-Polnik, M., Grajkowska, W. A., Kim, S. K., Rutka, J. T., Malkin, D., Tabori, U., Pfister, S. M., Korshunov, A., Von Deimling, A. & Taylor, M. D., Dec 2013, In: Acta Neuropathologica. 126, 6, p. 917-929 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    130 Citations (Scopus)
  • The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

    Kerl, K., Ries, D., Unland, R., Borchert, C., Moreno, N., Hasselblatt, M., Jürgens, H., Kool, M., Görlich, D., Eveslage, M., Jung, M., Meisterernst, M. & Frühwald, M., 13 Jun 2013, In: BMC Cancer. 13, 286.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    42 Citations (Scopus)
  • The role of chromatin remodeling in medulloblastoma

    Jones, D. T. W., Northcott, P. A., Kool, M. & Pfister, S. M., Mar 2013, In: Brain Pathology. 23, 2, p. 193-199 7 p.

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)
  • XHypermutation of the inactive X chromosome is a frequent event in cancer

    Jäger, N., Schlesner, M., Jones, D. T. W., Raffel, S., Mallm, J. P., Junge, K. M., Weichenhan, D., Bauer, T., Ishaque, N., Kool, M., Northcott, P. A., Korshunov, A., Drews, R. M., Koster, J., Versteeg, R., Richter, J., Hummel, M., Mack, S. C., Taylor, M. D., Witt, H., & 16 othersSwartman, B., Schulte-Bockholt, D., Sultan, M., Yaspo, M. L., Lehrach, H., Hutter, B., Brors, B., Wolf, S., Plass, C., Siebert, R., Trumpp, A., Rippe, K., Lehmann, I., Lichter, P., Pfister, S. M. & Eils, R., 24 Oct 2013, In: Cell. 155, 3, p. 567 1 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    58 Citations (Scopus)
  • XThe eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

    Leprivier, G., Remke, M., Rotblat, B., Dubuc, A., Mateo, A. R. F., Kool, M., Agnihotri, S., El-Naggar, A., Yu, B., Prakash Somasekharan, S., Faubert, B., Bridon, G., Tognon, C. E., Mathers, J., Thomas, R., Li, A., Barokas, A., Kwok, B., Bowden, M., Smith, S., & 19 othersWu, X., Korshunov, A., Hielscher, T., Northcott, P. A., Galpin, J. D., Ahern, C. A., Wang, Y., McCabe, M. G., Collins, V. P., Jones, R. G., Pollak, M., Delattre, O., Gleave, M. E., Jan, E., Pfister, S. M., Proud, C. G., Derry, W. B., Taylor, M. D. & Sorensen, P. H., 23 May 2013, In: Cell. 153, 5, p. 1064 1 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    313 Citations (Scopus)
  • 2012

    Biological and clinical heterogeneity of MYCN-amplified medulloblastoma

    Korshunov, A., Remke, M., Kool, M., Hielscher, T., Northcott, P. A., Williamson, D., Pfaff, E., Witt, H., Jones, D. T. W., Ryzhova, M., Cho, Y. J., Wittmann, A., Benner, A., Weiss, W. A., Von Deimling, A., Scheurlen, W., Kulozik, A. E., Clifford, S. C., Collins, V. P., Westermann, F., & 3 othersTaylor, M. D., Lichter, P. & Pfister, S. M., Apr 2012, In: Acta Neuropathologica. 123, 4, p. 515-527 13 p.

    Research output: Contribution to journalArticlepeer-review

    61 Citations (Scopus)
  • Dissecting the genomic complexity underlying medulloblastoma

    Jones, D. T. W., Jäger, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y. J., Pugh, T. J., Hovestadt, V., Stütz, A. M., Rausch, T., Warnatz, H. J., Ryzhova, M., Bender, S., Sturm, D., Pleier, S., Cin, H., Pfaff, E., Sieber, L., Wittmann, A., & 70 othersRemke, M., Witt, H., Hutter, S., Tzaridis, T., Weischenfeldt, J., Raeder, B., Avci, M., Amstislavskiy, V., Zapatka, M., Weber, U. D., Wang, Q., Lasitschka, B., Bartholomae, C. C., Schmidt, M., von Kalle, C., Ast, V., Lawerenz, C., Eils, J., Kabbe, R., Benes, V., van Sluis, P., Koster, J., Volckmann, R., Shih, D., Betts, M. J., Russell, R. B., Coco, S., Tonini, G. P., Schüller, U., Hans, V., Graf, N., Kim, Y. J., Monoranu, C., Roggendorf, W., Unterberg, A., Herold-Mende, C., Milde, T., Kulozik, A. E., von Deimling, A., Witt, O., Maass, E., Rössler, J., Ebinger, M., Schuhmann, M. U., Frühwald, M. C., Hasselblatt, M., Jabado, N., Rutkowski, S., von Bueren, A. O., Williamson, D., Clifford, S. C., Mc Cabe, M. G., Collins, V. P., Wolf, S., Wiemann, S., Lehrach, H., Brors, B., Scheurlen, W., Felsberg, J., Reifenberger, G., Northcott, P. A., Taylor, M. D., Meyerson, M., Pomeroy, S. L., Yaspo, M. L., Korbel, J. O., Korshunov, A., Eils, R., Pfister, S. M. & Lichter, P., 2 Aug 2012, In: Nature. 488, 7409, p. 100-105 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    675 Citations (Scopus)
  • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

    Schwartzentruber, J., Korshunov, A., Liu, X. Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D. A. K., Tönjes, M., Hovestadt, V., Albrecht, S., Kool, M., Nantel, A., Konermann, C., Lindroth, A., Jäger, N., Rausch, T., Ryzhova, M., Korbel, J. O., & 42 othersHielscher, T., Hauser, P., Garami, M., Klekner, A., Bognar, L., Ebinger, M., Schuhmann, M. U., Scheurlen, W., Pekrun, A., Frühwald, M. C., Roggendorf, W., Kramm, C., Dürken, M., Atkinson, J., Lepage, P., Montpetit, A., Zakrzewska, M., Zakrzewski, K., Liberski, P. P., Dong, Z., Siegel, P., Kulozik, A. E., Zapatka, M., Guha, A., Malkin, D., Felsberg, J., Reifenberger, G., Von Deimling, A., Ichimura, K., Collins, V. P., Witt, H., Milde, T., Witt, O., Zhang, C., Castelo-Branco, P., Lichter, P., Faury, D., Tabori, U., Plass, C., Majewski, J., Pfister, S. M. & Jabado, N., 9 Feb 2012, In: Nature. 482, 7384, p. 226-231 6 p.

    Research output: Contribution to journalArticlepeer-review

    1862 Citations (Scopus)
  • Erratum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma (Nature (2012) 482 (226-231))

    Schwartzentruber, J., Korshunov, A., Liu, X. Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D. A. K., Tönjes, M., Hovestadt, V., Albrecht, S., Kool, M., Nantel, A., Konermann, C., Lindroth, A., Jäger, N., Rausch, T., Ryzhova, M., Korbel, J. O., & 42 othersHielscher, T., Hauser, P., Garami, M., Klekner, A., Bognar, L., Ebinger, M., Schuhmann, M. U., Scheurlen, W., Pekrun, A., Frühwald, M. C., Roggendorf, W., Kramm, C., Dürken, M., Atkinson, J., Lepage, P., Montpetit, A., Zakrzewska, M., Zakrzewski, K., Liberski, P. P., Dong, Z., Siegel, P., Kulozik, A. E., Zapatka, M., Guha, A., Malkin, D., Felsberg, J., Reifenberger, G., Von Deimling, A., Ichimura, K., Collins, V. P., Witt, H., Milde, T., Witt, O., Zhang, C., Castelo-Branco, P., Lichter, P., Faury, D., Tabori, U., Plass, C., Majewski, J., Pfister, S. M. & Jabado, N., 5 Apr 2012, In: Nature. 484, 7392, p. 130 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
    11 Citations (Scopus)
  • EZH2-regulated DAB2IP is a medulloblastoma tumor suppressor and a positive marker for survival

    Smits, M., van Rijn, S., Hulleman, E., Biesmans, D., van Vuurden, D., Kool, M., Haberler, C., Aronica, E., Vandertop, W. P., Noske, D. P. & Wurdinger, T., 1 Aug 2012, In: Clin Cancer Res. 18, 15, p. 4048-4058 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    64 Citations (Scopus)
  • Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

    Liu, X. Y., Gerges, N., Korshunov, A., Sabha, N., Khuong-Quang, D. A., Fontebasso, A. M., Fleming, A., Hadjadj, D., Schwartzentruber, J., Majewski, J., Dong, Z., Siegel, P., Albrecht, S., Croul, S., Jones, D. T. W., Kool, M., Tonjes, M., Reifenberger, G., Faury, D., Zadeh, G., & 2 othersPfister, S. & Jabado, N., Nov 2012, In: Acta Neuropathologica. 124, 5, p. 615-625 11 p.

    Research output: Contribution to journalArticlepeer-review

    321 Citations (Scopus)
  • Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

    Rausch, T., Jones, D. T. W., Zapatka, M., Stütz, A. M., Zichner, T., Weischenfeldt, J., Jäger, N., Remke, M., Shih, D., Northcott, P. A., Pfaff, E., Tica, J., Wang, Q., Massimi, L., Witt, H., Bender, S., Pleier, S., Cin, H., Hawkins, C., Beck, C., & 31 othersVon Deimling, A., Hans, V., Brors, B., Eils, R., Scheurlen, W., Blake, J., Benes, V., Kulozik, A. E., Witt, O., Martin, D., Zhang, C., Porat, R., Merino, D. M., Wasserman, J., Jabado, N., Fontebasso, A., Bullinger, L., Rücker, F. G., Döhner, K., Döhner, H., Koster, J., Molenaar, J. J., Versteeg, R., Kool, M., Tabori, U., Malkin, D., Korshunov, A., Taylor, M. D., Lichter, P., Pfister, S. M. & Korbel, J. O., 20 Jan 2012, In: Cell. 148, 1-2, p. 59-71 13 p.

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    662 Citations (Scopus)
  • HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment

    Milde, T., Lodrini, M., Savelyeva, L., Korshunov, A., Kool, M., Brueckner, L. M., Antunes, A. S. L. M., Oehme, I., Pekrun, A., Pfister, S. M., Kulozik, A. E., Witt, O. & Deubzer, H. E., Dec 2012, In: Journal of Neuro-Oncology. 110, 3, p. 335-348 14 p.

    Research output: Contribution to journalArticlepeer-review

    100 Citations (Scopus)
  • Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

    Sturm, D., Witt, H., Hovestadt, V., Khuong-Quang, D. A., Jones, D. T. W., Konermann, C., Pfaff, E., Tönjes, M., Sill, M., Bender, S., Kool, M., Zapatka, M., Becker, N., Zucknick, M., Hielscher, T., Liu, X. Y., Fontebasso, A. M., Ryzhova, M., Albrecht, S., Jacob, K., & 58 othersWolter, M., Ebinger, M., Schuhmann, M. U., van Meter, T., Frühwald, M. C., Hauch, H., Pekrun, A., Radlwimmer, B., Niehues, T., Von Komorowski, G., Dürken, M., Kulozik, A. E., Madden, J., Donson, A., Foreman, N. K., Drissi, R., Fouladi, M., Scheurlen, W., von Deimling, A., Monoranu, C., Roggendorf, W., Herold-Mende, C., Unterberg, A., Kramm, C. M., Felsberg, J., Hartmann, C., Wiestler, B., Wick, W., Milde, T., Witt, O., Lindroth, A. M., Schwartzentruber, J., Faury, D., Fleming, A., Zakrzewska, M., Liberski, P. P., Zakrzewski, K., Hauser, P., Garami, M., Klekner, A., Bognar, L., Morrissy, S., Cavalli, F., Taylor, M. D., van Sluis, P., Koster, J., Versteeg, R., Volckmann, R., Mikkelsen, T., Aldape, K., Reifenberger, G., Collins, V. P., Majewski, J., Korshunov, A., Lichter, P., Plass, C., Jabado, N. & Pfister, S. M., 16 Oct 2012, In: Cancer Cell. 22, 4, p. 425-437 13 p.

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    1374 Citations (Scopus)
  • K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

    Khuong-Quang, D. A., Buczkowicz, P., Rakopoulos, P., Liu, X. Y., Fontebasso, A. M., Bouffet, E., Bartels, U., Albrecht, S., Schwartzentruber, J., Letourneau, L., Bourgey, M., Bourque, G., Montpetit, A., Bourret, G., Lepage, P., Fleming, A., Lichter, P., Kool, M., Von Deimling, A., Sturm, D., & 7 othersKorshunov, A., Faury, D., Jones, D. T., Majewski, J., Pfister, S. M., Jabado, N. & Hawkins, C., Sept 2012, In: Acta Neuropathologica. 124, 3, p. 439-447 9 p.

    Research output: Contribution to journalArticlepeer-review

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    707 Citations (Scopus)
  • LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)

    Korshunov, A., Ryzhova, M., Jones, D. T. W., Northcott, P. A., Van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., Cowdrey, C., Perry, A., Picard, D., Rosenblum, M., Giangaspero, F., Aronica, E., Schüller, U., Hasselblatt, M., Collins, V. P., Von Deimling, A., Lichter, P., Huang, A., & 2 othersPfister, S. M. & Kool, M., Dec 2012, In: Acta Neuropathologica. 124, 6, p. 875-881 7 p.

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    Open Access
    105 Citations (Scopus)
  • Medulloblastomics: The end of the beginning

    Northcott, P. A., Jones, D. T. W., Kool, M., Robinson, G. W., Gilbertson, R. J., Cho, Y. J., Pomeroy, S. L., Korshunov, A., Lichter, P., Taylor, M. D. & Pfister, S. M., Dec 2012, In: Nature Reviews Cancer. 12, 12, p. 818-834 17 p.

    Research output: Contribution to journalReview articlepeer-review

    517 Citations (Scopus)
  • MicroRNA-182 promot es leptomeningeal spread of non-sonic hedgehog-medulloblastoma

    Bai, A. H. C., Milde, T., Remke, M., Rolli, C. G., Hielscher, T., Cho, Y. J., Kool, M., Northcott, P. A., Jugold, M., Bazhin, A. V., Eichmüller, S. B., Kulozik, A. E., Pscherer, A., Benner, A., Taylor, M. D., Pomeroy, S. L., Kemkemer, R., Witt, O., Korshunov, A., Lichter, P., & 1 othersPfister, S. M., Apr 2012, In: Acta Neuropathologica. 123, 4, p. 529-538 10 p.

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)
  • Mismatch repair deficiency: A temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours

    Von Bueren, A. O., Bacolod, M. D., Hagel, C., Heinimann, K., Fedier, A., Kordes, U., Pietsch, T., Koster, J., Grotzer, M. A., Friedman, H. S., Marra, G., Kool, M. & Rutkowski, S., 9 Oct 2012, In: British Journal of Cancer. 107, 8, p. 1399-1408 10 p.

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    30 Citations (Scopus)
  • Molecular subgroups of medulloblastoma: The current consensus

    Taylor, M. D., Northcott, P. A., Korshunov, A., Remke, M., Cho, Y. J., Clifford, S. C., Eberhart, C. G., Parsons, D. W., Rutkowski, S., Gajjar, A., Ellison, D. W., Lichter, P., Gilbertson, R. J., Pomeroy, S. L., Kool, M. & Pfister, S. M., Apr 2012, In: Acta Neuropathologica. 123, 4, p. 465-472 8 p.

    Research output: Contribution to journalArticlepeer-review

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    1376 Citations (Scopus)
  • Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

    Kool, M., Korshunov, A., Remke, M., Jones, D. T. W., Schlanstein, M., Northcott, P. A., Cho, Y-J., Koster, J., Schouten-van Meeteren, A., van Vuurden, D., Clifford, S. C., Pietsch, T., von Bueren, A. O., Rutkowski, S., McCabe, M., Collins, V. P., Bäcklund, M. L., Haberler, C., Bourdeaut, F., Delattre, O., & 7 othersDoz, F., Ellison, D. W., Gilbertson, R. J., Pomeroy, S. L., Taylor, M. D., Lichter, P. & Pfister, S. M., Apr 2012, In: Acta Neuropathologica. 123, 4, p. 473-84 12 p.

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    774 Citations (Scopus)
  • Nestin expression identifies ependymoma patients with poor outcome

    Milde, T., Hielscher, T., Witt, H., Kool, M., MacK, S. C., Deubzer, H. E., Oehme, I., Lodrini, M., Benner, A., Taylor, M. D., Von Deimling, A., Kulozik, A. E., Pfister, S. M., Witt, O. & Korshunov, A., Nov 2012, In: Brain Pathology. 22, 6, p. 848-860 13 p.

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)
  • OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells

    Bunt, J., Hasselt, N. E., Zwijnenburg, D. A., Hamdi, M., Koster, J., Versteeg, R. & Kool, M., 15 Jul 2012, In: International journal of cancer. 131, 2

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    Open Access
    64 Citations (Scopus)
  • Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

    Northcott, P. A., Shih, D. J. H., Remke, M., Cho, Y. J., Kool, M., Hawkins, C., Eberhart, C. G., Dubuc, A., Guettouche, T., Cardentey, Y., Bouffet, E., Pomeroy, S. L., Marra, M., Malkin, D., Rutka, J. T., Korshunov, A., Pfister, S. & Taylor, M. D., Apr 2012, In: Acta Neuropathologica. 123, 4, p. 615-626 12 p.

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    304 Citations (Scopus)
  • Sonic hedgehog-associated medullobla stoma arising from the cochlear nuclei of the brainstem

    Grammel, D., Warmuth-Metz, M., Von Bueren, A. O., Kool, M., Pietsch, T., Kretzschmar, H. A., Rowitch, D. H., Rutkowski, S., Pfister, S. M. & Schüller, U., Apr 2012, In: Acta Neuropathologica. 123, 4, p. 601-614 14 p.

    Research output: Contribution to journalArticlepeer-review

    67 Citations (Scopus)
  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes

    Northcott, P. A., Shih, D. J. H., Peacock, J., Garzia, L., Sorana Morrissy, A., Zichner, T., Stútz, A. M., Korshunov, A., Reimand, J., Schumacher, S. E., Beroukhim, R., Ellison, D. W., Marshall, C. R., Lionel, A. C., MacK, S., Dubuc, A., Yao, Y., Ramaswamy, V., Luu, B., Rolider, A., & 115 othersCavalli, F. M. G., Wang, X., Remke, M., Wu, X., Chiu, R. Y. B., Chu, A., Chuah, E., Corbett, R. D., Hoad, G. R., Jackman, S. D., Li, Y., Lo, A., Mungall, K. L., Ming Nip, K., Qian, J. Q., Raymond, A. G. J., Thiessen, N., Varhol, R. J., Birol, I., Moore, R. A., Mungall, A. J., Holt, R., Kawauchi, D., Roussel, M. F., Kool, M., Jones, D. T. W., Witt, H., Fernandez-L, A., Kenney, A. M., Wechsler-Reya, R. J., Dirks, P., Aviv, T., Grajkowska, W. A., Perek-Polnik, M., Haberler, C. C., Delattre, O., Reynaud, S. S., Doz, F. F., Pernet-Fattet, S. S., Cho, B. K., Kim, S. K., Wang, K. C., Scheurlen, W., Eberhart, C. G., Fèvre-Montange, M., Jouvet, A., Pollack, I. F., Fan, X., Muraszko, K. M., Yancey Gillespie, G., Di Rocco, C., Massimi, L., Michiels, E. M. C., Kloosterhof, N. K., French, P. J., Kros, J. M., Olson, J. M., Ellenbogen, R. G., Zitterbart, K., Kren, L., Thompson, R. C., Cooper, M. K., Lach, B., McLendon, R. E., Bigner, D. D., Fontebasso, A., Albrecht, S., Jabado, N., Lindsey, J. C., Bailey, S., Gupta, N., Weiss, W. A., Bognár, L., Klekner, A., Van Meter, T. E., Kumabe, T., Tominaga, T., Elbabaa, S. K., Leonard, J. R., Rubin, J. B., Liau, L. M., Van Meir, E. G., Fouladi, M., Nakamura, H., Cinalli, G., Garami, M., Hauser, P., Saad, A. G., Iolascon, A., Jung, S., Carlotti, C. G., Vibhakar, R., Shin Ra, Y., Robinson, S., Zollo, M., Faria, C. C., Chan, J. A., Levy, M. L., Sorensen, P. H. B., Meyerson, M., Pomeroy, S. L., Cho, Y. J., Bader, G. D., Tabori, U., Hawkins, C. E., Bouffet, E., Scherer, S. W., Rutka, J. T., Malkin, D., Clifford, S. C., Jones, S. J. M., Korbel, J. O., Pfister, S. M., Marra, M. A. & Taylor, M. D., 2 Aug 2012, In: Nature. 487, 7409, p. 49-56 8 p.

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    676 Citations (Scopus)
  • Update on molecular and genetic alterations in adult medulloblastoma

    Kool, M., Korshunov, A. & Pfister, S. M., Sept 2012, In: Memo - Magazine of European Medical Oncology. 5, 3, p. 228-232 5 p.

    Research output: Contribution to journalReview articlepeer-review

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    24 Citations (Scopus)
  • 2011

    Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans

    Pöschl, J., Lorenz, A., Hartmann, W., Von Bueren, A. O., Kool, M., Li, S., Peraud, A., Tonn, J. C., Herms, J., Xiang, M., Rutkowski, S., Kretzschmar, H. A. & Schüller, U., 24 Nov 2011, In: Oncogene. 30, 47, p. 4721-4730 10 p.

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)
  • FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

    Remke, M., Hielscher, T., Korshunov, A., Northcott, P. A., Bender, S., Kool, M., Westermann, F., Benner, A., Cin, H., Ryzhova, M., Sturm, D., Witt, H., Haag, D., Toedt, G., Wittmann, A., Schöttler, A., Von Bueren, A. O., Von Deimling, A., Rutkowski, S., Scheurlen, W., & 4 othersKulozik, A. E., Taylor, M. D., Lichter, P. & Pfister, S. M., 11 Oct 2011, In: Journal of Clinical Oncology. 29, 29, p. 3852-3861 10 p.

    Research output: Contribution to journalArticlepeer-review

    137 Citations (Scopus)
  • High levels of PROM1 (CD133) transcript are a potential predictor of poor prognosis in medulloblastoma

    Raso, A., Mascelli, S., Biassoni, R., Nozza, P., Kool, M., Pistorio, A., Ugolotti, E., Milanaccio, C., Pignatelli, S., Ferraro, M., Pavanello, M., Ravegnani, M., Cama, A., Garré, M. L. & Capra, V., May 2011, In: Neuro-Oncology. 13, 5, p. 500-508 9 p.

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)
  • Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

    Cho, Y. J., Tsherniak, A., Tamayo, P., Santagata, S., Ligon, A., Greulich, H., Berhoukim, R., Amani, V., Goumnerova, L., Eberhart, C. G., Lau, C. C., Olson, J. M., Gilbertson, R. J., Gajjar, A., Delattre, O., Kool, M., Ligon, K., Meyerson, M., Mesirov, J. P. & Pomeroy, S. L., 10 Apr 2011, In: Journal of Clinical Oncology. 29, 11, p. 1424-1430 7 p.

    Research output: Contribution to journalArticlepeer-review

    563 Citations (Scopus)
  • Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma

    Bunt, J., Hasselt, N. E., Zwijnenburg, D. A., Koster, J., Versteeg, R. & Kool, M., 10 Oct 2011, In: PloS one. 6, 10, e26058.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Citations (Scopus)
  • PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

    van Vuurden, D., Hulleman, E., Meijer, O. L. M., Wedekind, L. E., Kool, M., Witt, H., Vandertop, W. P., Wurdinger, T., Noske, D. P., Kaspers, G. & Cloos, J., Dec 2011, In: Oncotarget. 2, 12, p. 984-996 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    77 Citations (Scopus)
  • Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features

    Tamayo, P., Cho, Y. J., Tsherniak, A., Greulich, H., Ambrogio, L., Meeteren, N. S. V., Zhou, T., Buxton, A., Kool, M., Meyerson, M., Pomeroy, S. L. & Mesirov, J. P., 10 Apr 2011, In: Journal of Clinical Oncology. 29, 11, p. 1415-1423 9 p.

    Research output: Contribution to journalArticlepeer-review

    65 Citations (Scopus)
  • 2010

    Fanconi anemia gene mutations are not involved in sporadic Wilms tumor

    Adank, M. A., Segers, H., Van Mil, S. E., Van Helsdingen, Y. M., Ameziane, N., Van Den Ouweland, A. M. W., Wagner, A., Meijers-Heijboer, H., Kool, M., De Kraker, J., Waisfisz, Q. & Van Den Heuvel-Eibrink, M. M., Oct 2010, In: Pediatric Blood and Cancer. 55, 4, p. 742-744 3 p.

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)