Ruben van Boxtel

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Ruben van Boxtel

 https://orcid.org/0000-0003-1285-2836
Calculated based on number of publications stored in Pure and citations from Scopus
20082025

Research activity per year

Search results

  • 2018

    Megakaryocyte lineage development is controlled by modulation of protein acetylation

    Bartels, M., Govers, A., Polak, R., Vervoort, S., Van Boxtel, R., Pals, C., Bierings, M., Van Solinge, W., Egberts, T., Nieuwenhuis, E., Mokry, M. & Coffer, P. J., Apr 2018, In: PLoS ONE. 13, 4, e0196400.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Citations (Scopus)

  • MutationalPatterns: Comprehensive genome-wide analysis of mutational processes

    Blokzijl, F., Janssen, R., van Boxtel, R. & Cuppen, E., 2018, In: Genome Medicine. 10, 1, 33.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    438 Citations (Scopus)

  • Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

    Osorio, F. G., Rosendahl Huber, A., Oka, R., Verheul, M., Patel, S. H., Hasaart, K., de la Fonteijne, L., Varela, I., Camargo, F. D. & van Boxtel, R., 27 Nov 2018, In: Cell reports. 25, 9, p. 2308-2316.e4

    Research output: Contribution to journal › Article › peer-review

    Open Access
    168 Citations (Scopus)

  • STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells

    Ribeiro, D., Melão, A., Van Boxtel, R., Santos, C. I., Silva, A., Silva, M. C., Cardoso, B. A., Coffer, P. J. & Barata, J. T., 11 Sept 2018, In: Blood Advances. 2, 17, p. 2199-2213 15 p.

    Research output: Contribution to journal › Article › peer-review

    66 Citations (Scopus)
  • 2017

    Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

    Fumagalli, A., Drost, J., Suijkerbuijk, S. J. E., van Boxtel, R., de Ligt, J., Offerhaus, G. J., Begthel, H., Beerling, E., Tan, E. H., Sansom, O. J., Cuppen, E., Clevers, H. & van Rheenen, J., 21 Mar 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. E2357-E2364

    Research output: Contribution to journal › Article › peer-review

    Open Access
    204 Citations (Scopus)

  • Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney

    Schutgens, F., Rookmaaker, M. B., Blokzijl, F., Van Boxtel, R., Vries, R., Cuppen, E., Verhaar, M. C. & Clevers, H., 26 Dec 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11190-E11198

    Research output: Contribution to journal › Article › peer-review

    20 Citations (Scopus)

  • Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

    Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., Nik-Zainal, S., Kuiper, R. P., Cuppen, E. & Clevers, H., 13 Oct 2017, In: Science. 358, 6360, p. 234-238 5 p.

    Research output: Contribution to journal › Article › peer-review

    326 Citations (Scopus)
  • 2016

    Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats

    Chen, X., Walther, F. J., van Boxtel, R., Laghmani, E. H., Sengers, R. M. A., Folkerts, G., Deruiter, M. C., Cuppen, E. & Wagenaar, G. T. M., 1 Mar 2016, In: Acta Physiologica. 216, 3, p. 358-375 18 p.

    Research output: Contribution to journal › Article › peer-review

    20 Citations (Scopus)

  • The role of the dopamine D1 receptor in social cognition: Studies using a novel genetic rat model

    Homberg, J. R., Olivier, J. D. A., VandenBroeke, M., Youn, J., Ellenbroek, A. K., Karel, P., Shan, L., Van Boxtel, R., Ooms, S., Balemans, M., Langedijk, J., Muller, M., Vriend, G., Cools, A. R., Cuppen, E. & Ellenbroek, B. A., 1 Oct 2016, In: DMM Disease Models and Mechanisms. 9, 10, p. 1147-1158 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    41 Citations (Scopus)

  • Tissue-specific mutation accumulation in human adult stem cells during life

    Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., Nijman, I. J., Martincorena, I., Mokry, M., Wiegerinck, C. L., Middendorp, S., Sato, T., Schwank, G., Nieuwenhuis, E. E. S., Verstegen, M. M. A. & van der Laan, L. J. W. & 8 others, de Jonge, J., IJzermans, J. N. M., Vries, R. G., van de Wetering, M., Stratton, M. R., Clevers, H., Cuppen, E. & van Boxtel, R., 13 Oct 2016, In: Nature. 538, 7624, p. 260-264 5 p.

    Research output: Contribution to journal › Article › peer-review

    695 Citations (Scopus)
  • 2015

    Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

    Murray, D. D., Suzuki, K., Law, M., Trebicka, J., Neuhaus, J., Wentworth, D., Johnson, M., Vjecha, M. J., Kelleher, A. D., Emery, S., Aagaard, B., Aragon, E., Arnaiz, J., Borup, L., Clotet, B., Dragsted, U., Fau, A., Gey, D., Grarup, J. & Hengge, U. & 1,472 others, Herrero, P., Jansson, P., Jensen, B., Jensen, K., Juncher, H., Lopez, P., Lundgren, J. D., Matthews, C., Mollerup, D., Pearson, M., Phillips, A., Reilev, S., Tillmann, K., Varea, S., Angus, B., Babiker, A., Cordwell, B., Darbyshire, J., Dodds, W., Fleck, S., Horton, J., Hudson, F., Moraes, Y., Pacciarini, F., Palfreeman, A., Paton, N., Smith, N., Van Hooff, F., Bebchuk, J., Collins, G., Denning, E., DuChene, A., Fosdick, L., Harrison, M., Herman-Lamin, K., Krum, E., Larson, G., Neaton, J., Nelson, R., Quan, K., Quan, S., Schultz, T., Thompson, G., Wyman, N., Carey, C., Chan, F., Cooper, D., Courtney-Rodgers, D., Drummond, F., Harrod, M., Jacoby, S., Kearney, L., Lin, E., Pett, S., Robson, R., Seneviratne, N., Stewart, M., Watts, E., Finley, E., Gordin, F., Sánchez, A., Standridge, B., Belloso, W., Davey, R., Duprez, D., Gatell, J., Hoy, J., Lifson, A., Pederson, C., Perez, G., Price, R., Prineas, R., Rhame, F., Sampson, J., Worley, J., Modlin, J., Beral, V., Chaisson, R., Fleming, T., Hill, C., Kim, K., Murray, B., Pick, B., Seligmann, M., Weller, I., Cahill, K., Fox, L., Luzar, M., Martinez, A., McNay, L., Pierson, J., Tierney, J., Vogel, S., Costas, V., Eckstrand, J., Brown, S., Abusamra, L., Angel, E., Aquilia, S., Benetucci, J., Bittar, V., Bogdanowicz, E., Cahn, P., Casiro, A., Contarelli, J., Corral, J., Daciuk, L., David, D., Dobrzanski, W., Duran, A., Ebenrstejin, J., Ferrari, I., Fridman, D., Galache, V., Guaragna, G., Ivalo, S., Krolewiecki, A., Lanusse, I., Laplume, H., Lasala, M., Lattes, R., Lazovski, J., Lopardo, G., Losso, M., Lourtau, L., Lupo, S., Maranzana, A., Marson, C., Massera, L., Moscatello, G., Olivia, S., Otegui, I., Palacios, L., Parlante, A., Salomon, H., Sanchez, M., Somenzini, C., Suarez, C., Tocci, M., Toibaro, J., Zala, C., Agrawal, S., Ambrose, P., Anderson, C., Anderson, J., Baker, D., Beileiter, K., Blavius, K., Bloch, M., Boyle, M., Bradford, D., Britton, P., Brown, P., Busic, T., Cain, A., Carrall, L., Carson, S., Chenoweth, I., Chuah, J., Clark, F., Clemons, J., Clezy, K., Cortissos, P., Cunningham, N., Curry, M., Daly, L., D'Arcy-Evans, C., Del Rosario, R., Dinning, S., Dobson, P., Donohue, W., Doong, N., Downs, C., Edwards, E., Edwards, S., Egan, C., Ferguson, W., Finlayson, R., Forsdyke, C., Foy, L., Franic, T., Frater, A., French, M., Gleeson, D., Gold, J., Habel, P., Haig, K., Hardy, S., Holland, R., Hudson, J., Hutchison, R., Hyland, N., James, R., Johnston, C., Kelly, M., King, M., Kunkel, K., Lau, H., Leamy, J., Lester, D., Leung, J., Lohmeyer, A., Lowe, K., MacRae, K., Magness, C., Martinez, O., Maruszak, H., Medland, N., Miller, S., Murray, J., Negus, P., Newman, R., Ngieng, M., Nowlan, C., Oddy, J., Orford, N., Orth, D., Patching, J., Plummer, M., Price, S., Primrose, R., Prone, I., Ree, H., Remington, C., Richardson, R., Robinson, S., Rogers, G., Roney, J., Roth, N., Russell, D., Ryan, S., Sarangapany, J., Schmidt, T., Schneider, K., Shields, C., Silberberg, C., Shaw, D., Skett, J., Smith, D., Soo, T. M., Sowden, D., Street, A., Tee, B. K., Thomson, J., Topaz, S., Vale, R., Villella, C., Walker, A., Watson, A., Wendt, N., Williams, L., Youds, D., Aichelburg, A., Cichon, P., Gemeinhart, B., Rieger, A., Schmied, B., Touzeau-Romer, V., Vetter, N., Colebunders, R., Clumeck, N., DeRoo, A., Kabeya, K., O'Doherty, E., De Wit, S., De Salles Amorim, C., Basso, C., Flint, S., Kallas, E., Levi, G., Lewi, D., Pereira, L., Da Silva, M., Souza, T., Toscano, A., Angel, J., Arsenault, M., Bast, M., Beckthold, B., Bouchard, P., Chabot, I., Clarke, R., Cohen, J., Coté, P., Ellis, M., Gagne, C., Gill, J., Houde, M., Johnston, B., Jubinville, N., Kato, C., Lamoureux, N., Latendre-Paquette, J., Lindemulder, A., McNeil, A., McFarland, N., Montaner, J., Morrisseau, C., O'Neill, R., Page, G., Piche, A., Pongracz, B., Preziosi, H., Puri, L., Rachlis, A., Ralph, E., Raymond, I., Rouleau, D., Routy, J. P., Sandre, R., Seddon, T., Shafran, S., Sikora, C., Smaill, F., Stromberg, D., Trottier, S., Walmsley, S., Weiss, K., Williams, K., Zarowny, D., Baadegaard, B., Andersen, B., Boedker, K., Collins, P., Gerstoft, J., Jensen, L., Moller, H., Andersen, P. L., Loftheim, I., Mathiesen, L., Nielsen, H., Obel, N., Pedersen, C., Petersen, D., Jensen, L. P., Black, F. T., Aboulker, J. P., Aouba, A., Bensalem, M., Berthe, H., Blanc, C., Bornarel, D., Bouchaud, O., Boue, F., Bouvet, E., Brancon, C., Breaud, S., Brosseau, D., Brunet, A., Capitant, C., Ceppi, C., Chakvetadze, C., Cheneau, C., Chennebault, J. M., De Truchis, P., Delavalle, A. M., Delfraissy, J. F., Dellamonica, P., Dumont, C., Edeb, N., Fabre, G., Ferrando, S., Foltzer, A., Foubert, V., Gastaut, J. A., Gerbe, J., Girard, P. M., Goujard, C., Hoen, B., Honore, P., Hue, H., Hynh, T., Jung, C., Kahi, S., Katlama, C., Lang, J. M., Le Baut, V., Lefebvre, B., Leturque, N., Lévy, Y., Loison, J., Maddi, G., Maignan, A., Majerholc, C., De Boever, C., Meynard, J. L., Michelet, C., Michon, C., Mole, M., Netzer, E., Pialoux, G., Poizot-Martin, I., Raffi, F., Ratajczak, M., Ravaux, I., Reynes, J., Salmon-Ceron, D., Sebire, M., Simon, A., Tegna, L., Tisne-Dessus, D., Tramoni, C., Viard, J. P., Vidal, M., Viet-Peaucelle, C., Weiss, L., Zeng, A., Zucman, D., Adam, A., Arastéh, K., Behrens, G., Bergmann, F., Bickel, M., Bittner, D., Bogner, J., Brockmeyer, N., Darrelmann, N., Deja, M., Doerler, M., Esser, S., Faetkenheuer, G., Fenske, S., Gajetzki, S., Goebel, F., Gorriahn, D., Harrer, E., Harrer, T., Hartl, H., Hartmann, M., Heesch, S., Jakob, W., Jäger, H., Klinker, H., Kremer, G., Ludwig, C., Mantzsch, K., Mauss, S., Meurer, A., Niedermeier, A., Pittack, N., Plettenberg, A., Potthoff, A., Probst, M., Rittweger, M., Rockstroh, J., Ross, B., Rotty, J., Rund, E., Ruzicka, T., Schmidt, R., Schmutz, G., Schnaitmann, E., Schuster, D., Sehr, T., Spaeth, B., Staszewski, S., Stellbrink, H. J., Stephan, C., Stockey, T., Stoehr, A., Trein, A., Vaeth, T., Vogel, M., Wasmuth, J., Wengenroth, C., Winzer, R., Wolf, E., Mulcahy, F., Reidy, D., Cohen, Y., Drora, G., Eliezer, I., Godo, O., Kedem, E., Magen, E., Mamorsky, M., Pollack, S., Sthoeger, Z., Vered, H., Yust, I., Aiuti, F., Bechi, M., Bergamasco, A., Bertelli, D., Bruno, R., Butini, L., Cagliuso, M., Carosi, G., Casari, S., Chrysoula, V., Cologni, G., Conti, V., Costantini, A., Corpolongo, A., D'Offizi, G., Gaiottino, F., Di Pietro, M., Esposito, R., Filice, G., Francesco, M., Gianelli, E., Graziella, C., Magenta, L., Martellotta, F., Maserati, R., Mazzotta, F., Murdaca, G., Nardini, G., Nozza, S., Puppo, F., Pogliaghi, M., Ripamonti, D., Ronchetti, C., Rusconi, S., Rusconi, V., Sacchi, P., Silvia, N., Suter, F., Tambussi, G., Uglietti, A., Vechi, M., Vergani, B., Vichi, F., Vitiello, P., Iwamoto, A., Kikuchi, Y., Miyazaki, N., Mori, M., Nakamura, T., Odawara, T., Oka, S., Shirasaka, T., Tabata, M., Takano, M., Ueta, C., Watanabe, D., Yamamoto, Y., Erradey, I., Himmich, H., El Filali, K. M., Blok, W., Van Boxtel, R., Doevelaar, K. B. H., Van Eeden, A., Grijsen, M., Groot, M., Juttmann, J., Kuipers, M., Ligthart, S., Van Der Meulen, P., Lange, J., Langebeek, N., Reiss, P., Richter, C., Schoemaker, M., Schrijnders-Gudde, L., Septer-Bijleveld, E., Sprenger, H., Vermeulen, J., Ten Kate, R., Van De Ven, B., Bruun, J., Kvale, D., Maeland, A., Bakowska, E., Beniowski, M., Boron-Kaczmarska, A., Gasiorowski, J., Horban, A., Inglot, M., Knysz, B., Mularska, E., Parczewski, M., Pynka, M., Rymer, W., Szymczak, A., Aldir, M., Antunes, F., Baptista, C., Da Conceicao Vera, J., Doroana, M., Mansinho, K., Dos Santos, C. R. A., Valadas, E., Vaz Pinto, I., Chia, E., Foo, E., Karim, F., Lim, P. L., Panchalingam, A., Quek, A., Alcázar-Caballero, R., Arribas, J., Arrizabalaga, J., De Barron, X., Blanco, F., Bouza, E., Bravo, I., Calvo, S., Carbonero, L., Carpena, I., Castro, M., Cortes, L., Del Toro, M., Domingo, P., Elias, M., Espinosa, J., Estrada, V., Fernandez-Cruz, E., Fernández, P., Freud, H., Fuster, M., Garcia, A., Garcia, G., Garrido, R., Gijón, P., Gonzalez-García, J., Gil, I., González, A., González-Lahoz, J., Grosso, P. L., Gutierrez, M., Guzmán, E., Iribarren, J., Jiménez, M., Jou, A., Juega, J., Lopez, J., Lozano, F., Martín-Carbonero, L., Mata, R., Mateo, G., Menasalvas, A., Mirelles, C., De Miguel Prieto, J., Montes, M., Moreno, A., Moreno, J., Moreno, V., Muñoz, R., Ocampo, A., Ortega, E., Ortiz, L., Padilla, B., Parras, A., Paster, A., Pedreira, J., Peña, J., Perea, R., Portas, B., Puig, J., Pulido, F., Rebollar, M., De Rivera, J., Roca, V., Rodríguez-Arrondo, F., Rubio, R., Santos, J., Sanz, J., Sebastian, G., Segovia, M., Soriano, V., Tamargo, L., Viciana, P., Von Wichmann, M., Bratt, G., Hollander, A., Olov Pehrson, P., Petz, I., Sandstrom, E., Sönnerborg, A., Bernasconi, E., Gurtner, V., Ampunpong, U., Auchieng, C., Bowonwatanuwong, C., Chanchai, P., Chetchotisakd, P., Chuenyan, T., Duncombe, C., Horsakulthai, M., Kantipong, P., Laohajinda, K., Phanuphak, P., Pongsurachet, V., Pradapmook, S., Ruxruntham, K., Seekaew, S., Sonjai, A., Suwanagool, S., Techasathit, W., Ubolyam, S., Wankoon, J., Alexander, I., Dockrell, D., Easterbrook, P., Edwards, B., Evans, E., Fisher, M., Fox, R., Gazzard, B., Gilleran, G., Hand, J., Heald, L., Higgs, C., Jebakumar, S., Jendrulek, I., Johnson, S., Kinghorn, G., Kuldanek, K., Leen, C., Maw, R., McKernan, S., McLean, L., Morris, S., Murphy, M., O'Farrell, S., Ong, E., Peters, B., Stroud, C., Wansbrough-Jones, M., Weber, J., White, D., Williams, I., Wiselka, M., Yee, T., Adams, S., Allegra, D., Andrews, L., Aneja, B., Anstead, G., Arduino, R., Artz, R., Bailowitz, J., Banks, S., Baxter, J., Baum, J., Benator, D., Black, D., Boh, D., Bonam, T., Brito, M., Brockelman, J., Bruzzese, V., Burnside, A., Cafaro, V., Casey, K., Cason, L., Childress, G., Clark, C., Clifford, D., Climo, M., Cohn, D., Couey, P., Cuervo, H., Deeks, S., Dennis, M., Diaz-Linares, M., Dickerson, D., Diez, M., Di Puppo, J., Dodson, P., Dupre, D., Elion, R., Elliott, K., El-Sadr, W., Estes, M., Fabre, J., Farrough, M., Flamm, J., Follansbee, S., Foster, C., Frank, C., Franz, J., Frechette, G., Freidland, G., Frische, J., Fuentes, L., Funk, C., Geisler, C., Genther, K., Giles, M., Goetz, M., Gonzalez, M., Graeber, C., Graziano, F., Grice, D., Hahn, B., Hamilton, C., Hassler, S., Henson, A., Hopper, S., John, M., Johnson, L., Johnson, R., Jones, R., Kahn, J., Klimas, N., Kolber, M., Koletar, S., Labriola, A., Larsen, R., Lasseter, F., Lederman, M., Ling, T., Lusch, T., MacArthur, R., Machado, C., Makohon, L., Mandelke, J., Mannheimer, S., Markowitz, N., Martínez, M., Martinez, N., Mass, M., Masur, H., McGregor, D., McIntyre, D., McKee, J., McMullen, D., Mettinger, M., Middleton, S., Mieras, J., Mildvan, D., Miller, P., Miller, T., Mitchell, V., Mitsuyasu, R., Moanna, A., Mogridge, C., Moran, F., Murphy, R., Mushatt, D., Nahass, R., Nixon, D., O'Brien, S., Ojeda, J., Okhuysen, P., Olson, M., Osterberger, J., Owen, W., Pablovich, S., Patel, S., Pierone, G., Poblete, R., Potter, A., Preston, E., Rappoport, C., Regevik, N., Reyelt, M., Riney, L., Rodriguez-Barradas, M., Rodriguez, J., Roland, R., Rosmarin-DeStefano, C., Rossen, W., Rouff, J., Saag, M., Santiago, S., Sarria, J., Wirtz, S., Schmidt, U., Scott, C., Sheridan, A., Shin, A., Shrader, S., Simon, G., Slowinski, D., Smith, K., Spotkov, J., Sprague, C., States, D., Suh, C., Sullivan, J., Summers, K., Sweeton, B., Tan, V., Tanner, T., Tedaldi, E., Temesgen, Z., Thomas, D., Thompson, M., Tobin, C., Toro, N., Towner, W., Upton, K., Uy, J., Valenti, S., Van Der Horst, C., Vita, J., Voell, J., Walker, J., Walton, T., Wason, K., Watson, V., Wellons, A., Weise, J., White, M., Whitman, T., Williams, B., Williams, N., Windham, J., Witt, M., Workowski, K., Wortmann, G., Wright, T., Zelasky, C., Zwickl, B., Dietz, D., Chesson, C., Vjecha, M., Schmetter, B., Grue, L., Willoughby, M., Demers, A., Dragsted, U. B., Jensen, K. B., Jansson, P. O., Jensen, B. G., Benfield, T. L., Darbyshire, J. H., Babiker, G., Fleck, S. L., Collaco-Moraes, Y., Wyzydrag, L., Drummond, F. M., Connor, S. A., Satchell, C. S., Gunn, S., Delfino, M. A., Merlin, K., McGinley, C., Neaton, J. D., Bartsch, G., George, M., Grund, B., Hogan, C., Miller, C., Roediger, M. P., Thackeray, L., Campbell, C., Lahart, C., Perlman, D., Rein, M., DerSimonian, R., Brody, B. A., Daar, E. S., Dubler, N. N., Fleming, T. R., Freeman, D. J., Kahn, J. P., Kim, K. M., Medoff, G., Modlin, J. F., Moellering, R., Murray, B. E., Robb, M. L., Scharfstein, D. O., Sugarman, J., Tsiatis, A., Tuazon, C., Zoloth, L., Klingman, K., Lehrman, S., Belloso, W. H., Losso, M. H., Benetucci, J. A., Bogdanowicz, E. P., Cahn, P. E., Casiró, A. D., Cassetti, I., Contarelli, J. M., Corral, J. A., Crinejo, A., David, D. O., Ishida, M. T., Laplume, H. E., Lasala, M. B., Lupo, S. H., Masciottra, F., Michaan, M., Ruggieri, L., Salazar, E., Sánchez, M., Hoy, J. F., Rogers, G. D., Allworth, A. M., Anderson, J. S. C., Armishaw, J., Barnes, K., Carr, A., Chiam, A., Chuah, J. C. P., Curry, M. C., Dever, R. L., Donohue, W. A., Doong, N. C., Dwyer, D. E., Dyer, J., Eu, B., Ferguson, V. W., French, M. A. H., Garsia, R. J., Hudson, J. H., Jeganathan, S., Konecny, P., McCormack, C. L., McMurchie, M., Moore, R. J., Moussa, M. B., Piper, M., Read, T., Roney, J. J., Shaw, D. R., Silvers, J., Smith, D. J., Street, A. C., Vale, R. J., Wendt, N. A., Wood, H., Youds, D. W., Zillman, J., Tozeau, V., Dewit, S., De Roo, A., Leonard, P., Lynen, L., Moutschen, M., Pereira, L. C., Souza, T. N. L., Schechter, M., Zajdenverg, R., Almeida, M. M. T. B., Araujo, F., Bahia, F., Brites, C., Caseiro, M. M., Casseb, J., Etzel, A., Falco, G. G., Filho, E. C. J., Flint, S. R., Gonzales, R., Madruga, J. V. R., Passos, L. N., Reuter, T., Sidi, L. C., Toscano, A. L. C., Cherban, E., Conway, B., Dufour, C., Foster, A., Haase, D., Haldane, H., Klein, M., Lessard, B., Martel, A., Martel, C., Paradis, E., Schlech, W., Schmidt, S., Thompson, B., Vezina, S., Reyes, M. J. W., Northland, R., Ostergaard, L., Hergens, L., Loftheim, I. R., Raukas, M., Zilmer, K., Justinen, J., Ristola, M., Landman, R., Abel, S., Abgrall, S., Amat, K., Auperin, L., Barruet, R., Benalycherif, A., Benammar, N., Bentata, M., Besnier, J. M., Blanc, M., Cabié, A., Chavannet, P., Dargere, S., De La Tribonniere, X., Debord, T., Decaux, N., Delgado, J., Dupon, M., Durant, J., Frixon-Marin, V., Genet, C., Gérard, L., Gilquin, J., Jeantils, V., Kouadio, H., Leclercq, P., Lelièvre, J. D., Levy, Y., Michon, C. P., Nau, P., Pacanowski, J., Piketty, C., Salmon, D., Schmit, J. L., Serini, M. A., Tassi, S., Touam, F., Verdon, R., Weinbreck, P., Yazdanpanah, Y., Yeni, P., Fätkenheuer, G., Bitsch, S., Bogner, J. R., Goebel, F. D., Lehmann, C., Lennemann, T., Wasmuth, J. C., Wiedemeyer, K., Hatzakis, A., Touloumi, G., Antoniadou, A., Daikos, G. L., Dimitrakaki, A., Gargalianos-Kakolyris, P., Giannaris, M., Karafoulidou, A., Katsambas, A., Katsarou, O., Kontos, A. N., Kordossis, T., Lazanas, M. K., Panagopoulos, P., Panos, G., Paparizos, V., Papastamopoulos, V., Petrikkos, G., Sambatakou, H., Skoutelis, A., Tsogas, N., Xylomenos, G., Bergin, C. J., Mooka, B., Mamorksy, M. G., Agmon-Levin, N., Karplus, R., Maayan, S., Shahar, E., Turner, D., Abeli, C., Biglino, A., Bonora, S., De Gioanni, M., Di Perri, G., Montroni, M., Quirino, T., Raise, E., Honda, M., Ishisaka, M., Caplinskas, S., Uzdaviniene, V., Schmit, J. C., Staub, T., Mills, G. D., Blackmore, T., Masters, J. A., Morgan, J., Pithie, A., Brunn, J., Ormassen, V., La Rosa, A., Guerra, O., Espichan, M., Gutierrez, L., Mendo, F., Salazar, R., Knytz, B., Kwiatkowski, J., Castro, R. S., Horta, A., Miranda, A. C., Pinto, I. V., Vera, J., Rakhmanova, A., Vinogradova, E., Yakovlev, A., Zakharova, N., Wood, R., Orrel, C., Arnaiz, J. A., Carrillo, R., Dalmau, D., Jordano, Q., Knobel, H., Larrousse, M., Moreno, J. S., Oretaga, E., Pena, J. N., Hirschel, B., Spycher, R., Battegay, M., Bottone, S., Cavassini, M., Christen, A., Furrer, H. J., Gayet-Ageron, A., Genné, D., Hochstrasser, S., Moens, C., Müller, N., Nüesch, R., Ruxrungtham, K., Pumpradit, W., Dangthongdee, S., Kiertiburanakul, S., Klinbuayaem, V., Mootsikapun, P., Nonenoy, S., Piyavong, B., Prasithsirikul, W., Raksakulkarn, P., Gazzard, B. G., Ainsworth, J. G., Angus, B. J., Barber, T. J., Brook, M. G., Care, C. D., Chadwick, D. R., Chikohora, M., Churchill, D. R., Cornforth, D., Dockrell, D. H., Easterbrook, P. J., Fox, P. A., Gomez, P. A., Gompels, M. M., Harris, G. M., Herman, S., Jackson, A. G. A., Jebakumar, S. P. R., Kinghorn, G. R., Kuldanek, K. A., Larbalestier, N., Lumsden, M., Maher, T., Mantell, J., Muromba, L., Orkin, C. M., Peters, S., Peto, T. E. A., Portsmouth, S. D., Rajamanoharan, S., Ronan, Schwenk, A., Slinn, M. A., Stroud, C. J., Thomas, R. C., Wansbrough-Jones, M. H., Whiles, H. J., White, D. J., Williams, E., Williams, G., Youle, M., Abrams, D. I., Acosta, E. A., Adamski, A., Antoniskis, D., Aragon, D. R., Barnett, B. J., Baroni, C., Barron, M., Baxter, J. D., Beers, D., Beilke, M., Bemenderfer, Bernard, A., Besch, C. L., Bessesen, M. T., Bethel, J. T., Blue, S., Blum, J. D., Boarden, S., Bolan, R. K., Borgman, J. B., Brar, I., Braxton, B. K., Bredeek, U. F., Brennan, R., Britt, D. E., Bulgin-Coleman, D., Bullock, E., Campbell, B., Caras, S., Carroll, J., Casey, K. K., Chiang, F., Cindrich, R. B., Cohen, C., Coley, J., Condoluci, D. V., Contreras, R., Corser, J., Cozzolino, J., Crane, L. R., Daley, L., Dandridge, D., D'Antuono, V., Darcourt Rizo Patron, J. G., DeHovitz, J. A., DeJesus, E., DesJardin, J., Dietrich, C., Dolce, A., Erickson, D., Faber, L. L., Falbo, J., Farrough, M. J., Farthing, C. F., Ferrell-Gonzalez, P., Flynn, H., Frank, M., Freeman, K. F., French, N., Friedland, G., Fujita, N., Gahagan, L., Gilson, I., Goetz, M. B., Goodwin, E., Guity, C. K., Gulick, P., Gunderson, E. R., Hale, C. M., Hannah, K., Henderson, H., Hennessey, K., Henry, W. K., Higgins, T., Hodder, S. L., Horowitz, H. W., Howe-Pittman, M., Hubbard, J., Hudson, R., Hunter, H., Hutelmyer, C., Insignares, M. T., Jackson, L., Jenny, L., Johnson, D. L., Johnson, G., Johnson, J., Kaatz, J., Kaczmarski, J., Kagan, S., Kantor, C., Kempner, T., Kieckhaus, K., Kimmel, N., Klaus, B. M., Koeppe, J. R., Koirala, J., Kopka, J., Kostman, J. R., Kozal, M. J., Kumar, A., Lampiris, H., Lamprecht, C., Lattanzi, K. M., Lee, J., Leggett, J., Long, C., Loquere, A., Loveless, K., Lucasti, C. J., Luskin-Hawk, R., MacVeigh, M., Makohon, L. H., Markowitz, N. P., Marks, C., Martorell, C., McFeaters, E., McGee, B., McIntyre, D. M., McManus, E., Melecio, L. G., Melton, D., Mercado, S., Merrifield, E., Mieras, J. A., Mogyoros, M., Moran, F. M., Murphy, K., Mutic, S., Nadeem, I., Nadler, J. P., Ognjan, A., O'Hearn, M., O'Keefe, K., Okhuysen, P. C., Oldfield, E., Olson, D., Orenstein, R., Ortiz, R., Parpart, F., Pastore-Lange, V., Paul, S., Pavlatos, A., Pearce, D. D., Pelz, R., Peterson, S., Pitrak, D., Powers, S. L., Pujet, H. C., Raaum, J. W., Ravishankar, J., Reeder, J., Reilly, N. A., Reyelt, C., Riddell, J., Rimland, D., Robinson, M. L., Rodriguez, A. E., Rodriguez Derouen, V., Rosmarin, C., Rossen, W. L., Rouff, J. R., Sands, M., Savini, C., Schrader, S., Schulte, M. M., Scott, R., Seedhom, H., Sension, M., ShebleHall, A., Shuter, J., Slater, L. N., Slotten, R., Smith, M., Snap, S., States, D. M., Stringer, G., Summers, K. K., Swanson, K., Sweeton, I. B., Szabo, S., Tedaldi, E. M., Telzak, E. E., Thompson, M. A., Thompson, S., Bong, C. T. H., Vaccaro, A., Vasco, L. M., Vecino, I., Verlinghieri, G. K., Visnegarwala, F., Wade, H., Weis, S. E., Weise, J. A., Weissman, S., Wilkin, M., Witter, J. H., Wojtusic, L., Wright, T. J., Yeh, V., Young, B., Zeana, C., Zeh, J., Savio, E. & Vacarezza, M., 14 Oct 2015, In: PLoS ONE. 10, 10, e0139981.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Citations (Scopus)

  • Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

    D:A:D study group, the Royal Free Hospital Clinic Cohort, and the INSIGHT, SMART, and ESPRIT study groups, 1 Mar 2015, In: PLoS Medicine. 12, 3, e1001809.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    112 Citations (Scopus)

  • Genomic landscape of rat strain and substrain variation

    Hermsen, R., de Ligt, J., Spee, W., Blokzijl, F., Schäfer, S., Adami, E., Boymans, S., Flink, S., van Boxtel, R., van der Weide, R. H., Aitman, T., Hübner, N., Simonis, M., Tabakoff, B., Guryev, V. & Cuppen, E., 12 Dec 2015, In: BMC Genomics. 16, 1, 357.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    72 Citations (Scopus)

  • Long-term culture of genome-stable bipotent stem cells from adult human liver

    Huch, M., Gehart, H., Van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M. A., Ellis, E., Van Wenum, M., Fuchs, S. A., De Ligt, J., Van De Wetering, M., Sasaki, N., Boers, S. J., Kemperman, H., De Jonge, J., Ijzermans, J. N. M., Nieuwenhuis, E. E. S., Hoekstra, R., Strom, S. & Vries, R. R. G. & 3 others, Van Der Laan, L. J. W., Cuppen, E. & Clevers, H., 15 Jan 2015, In: Cell. 160, 1-2, p. 299-312 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1220 Citations (Scopus)

  • Organoid models of human and mouse ductal pancreatic cancer

    Boj, S. F., Hwang, C. I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., Gracanin, A., Oni, T., Yu, K. H., Van Boxtel, R., Huch, M., Rivera, K. D., Wilson, J. P., Feigin, M. E., Öhlund, D. & Handly-Santana, A. & 28 others, Ardito-Abraham, C. M., Ludwig, M., Elyada, E., Alagesan, B., Biffi, G., Yordanov, G. N., Delcuze, B., Creighton, B., Wright, K., Park, Y., Morsink, F. H. M., Molenaar, I. Q., Borel Rinkes, I. H., Cuppen, E., Hao, Y., Jin, Y., Nijman, I. J., Iacobuzio-Donahue, C., Leach, S. D., Pappin, D. J., Hammell, M., Klimstra, D. S., Basturk, O., Hruban, R. H., Offerhaus, G. J., Vries, R. G. J., Clevers, H. & Tuveson, D. A., 15 Jan 2015, In: Cell. 160, 1-2, p. 324-338 15 p.

    Research output: Contribution to journal › Article › peer-review

    1621 Citations (Scopus)

  • Sequential cancer mutations in cultured human intestinal stem cells

    Drost, J., van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R. M., Offerhaus, G. J., Begthel, H., Korving, J., van de Wetering, M., Schwank, G., Logtenberg, M., Cuppen, E., Snippert, H. J., Medema, J. P., Kops, G. J. P. L. & Clevers, H., 7 May 2015, In: Nature. 521, 7550, p. 43-7 5 p.

    Research output: Contribution to journal › Article › peer-review

    850 Citations (Scopus)

  • The forkhead transcription factor FOXP1 represses human plasma cell differentiation

    Van Keimpema, M., Grüneberg, L. J., Mokry, M., Van Boxtel, R., Van Zelm, M. C., Coffer, P., Pals, S. T. & Spaargaren, M., 29 Oct 2015, In: Blood. 126, 18, p. 2098-2109 12 p., 626176.

    Research output: Contribution to journal › Article › peer-review

    45 Citations (Scopus)
  • 2014

    Forkhead box P family members at the crossroad between tolerance and immunity: A balancing act

    Fleskens, V. & Van Boxtel, R., Mar 2014, In: International Reviews of Immunology. 33, 2, p. 94-109 16 p.

    Research output: Contribution to journal › Article › peer-review

    10 Citations (Scopus)

  • FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells

    Van Keimpema, M., Grüneberg, L. J., Mokry, M., Van Boxtel, R., Koster, J., Coffer, P. J., Pals, S. T. & Spaargaren, M., 29 Sept 2014, In: Blood. 124, 23, p. 3431-3440 10 p.

    Research output: Contribution to journal › Article › peer-review

    80 Citations (Scopus)

  • Genome sequencing of normal cells reveals developmental lineages and mutational processes

    Behjati, S., Huch, M., Van Boxtel, R., Karthaus, W., Wedge, D. C., Tamuri, A. U., Martincorena, I., Petljak, M., Alexandrov, L. B., Gundem, G., Tarpey, P. S., Roerink, S., Blokker, J., Maddison, M., Mudie, L., Robinson, B., Nik-Zainal, S., Campbell, P., Goldman, N. & Van De Wetering, M. & 3 others, Cuppen, E., Clevers, H. & Stratton, M. R., 18 Sept 2014, In: Nature. 513, 7518, p. 422-425 4 p.

    Research output: Contribution to journal › Article › peer-review

    267 Citations (Scopus)

  • Identification of multipotent luminal progenitor cells in human prostate organoid cultures

    Karthaus, W. R., Iaquinta, P. J., Drost, J., Gracanin, A., van Boxtel, R., Wongvipat, J., Dowling, C. M., Gao, D., Begthel, H., Sachs, N., Vries, R. G. J., Cuppen, E., Chen, Y., Sawyers, C. L. & Clevers, H. C., 25 Sept 2014, In: Cell. 159, 1, p. 163-175 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    586 Citations (Scopus)
  • 2013

    FOXP1 acts through a negative feedback loop to suppress FOXO-induced apoptosis

    Van Boxtel, R., Gomez-Puerto, C., Mokry, M., Eijkelenboom, A., Van Der Vos, K. E., Nieuwenhuis, E. E., Burgering, B. M., Lam, E. W. F. & Coffer, P. J., Sept 2013, In: Cell Death and Differentiation. 20, 9, p. 1219-1229 11 p.

    Research output: Contribution to journal › Article › peer-review

    48 Citations (Scopus)

  • Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

    Eijkelenboom, A., Mokry, M., De Wit, E., Smits, L. M., Polderman, P. E., Van Triest, M. H., Van Boxtel, R., Schulze, A., De Laat, W., Cuppen, E. & Burgering, B. M. T., 2013, In: Molecular Systems Biology. 9, 638.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    102 Citations (Scopus)

  • SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition

    Vervoort, S. J., Lourenço, A. R., van Boxtel, R. & Coffer, P. J., 3 Jan 2013, In: PLoS ONE. 8, 1, e53238.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    84 Citations (Scopus)

  • The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: Friend or foe¿

    Vervoort, S. J., Van Boxtel, R. & Coffer, P. J., 18 Jul 2013, In: Oncogene. 32, 29, p. 3397-3409 13 p.

    Research output: Contribution to journal › Review article › peer-review

    175 Citations (Scopus)
  • 2012

    Erratum: Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat (Obesity (2012) 20: 3 (612-621) DOI: 10.1038/oby.2011.81.)

    Mul, J. D., Van Boxtel, R., Bergen, D. J. M., Brans, M. A., Brakkee, J. H., Toonen, P. W., Garner, K. M., Adan, R. A. H. & Cuppen, E., Jul 2012, In: Obesity. 20, 7, p. 1545 1 p.

    Research output: Contribution to journal › Comment/debate

  • Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat

    Mul, J. D., Van Boxtel, R., Bergen, D. J. M., Brans, M. A. D., Brakkee, J. H., Toonen, P. W., Garner, K. M., Adan, R. A. H. & Cuppen, E., Mar 2012, In: Obesity. 20, 3, p. 612-621 10 p.

    Research output: Contribution to journal › Article › peer-review

    70 Citations (Scopus)

  • Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy

    Van Der Vos, K. E., Eliasson, P., Proikas-Cezanne, T., Vervoort, S. J., Van Boxtel, R., Putker, M., Van Zutphen, I. J., Mauthe, M., Zellmer, S., Pals, C., Verhagen, L. P., Koerkamp, M. J. A. G., Koen Braat, A., Dansen, T. B., Holstege, F. C., Gebhardt, R., Burgering, B. M. & Coffer, P. J., Aug 2012, In: Nature Cell Biology. 14, 8, p. 829-837 9 p.

    Research output: Contribution to journal › Article › peer-review

    220 Citations (Scopus)
  • 2011

    Generation of Genetically Modified Rodents Using Random ENU Mutagenesis

    van Boxtel, R. & Cuppen, E., 2011, Methods in Molecular Biology. Humana Press Inc., p. 295-308 14 p. (Methods in Molecular Biology; vol. 693).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

    5 Citations (Scopus)

  • Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency

    van Boxtel, R., Kuiper, R. V., Toonen, P. W., van Heesch, S., Hermsen, R., de Bruin, A. & Cuppen, E., Oct 2011, In: The American journal of pathology. 179, 4, p. 1616-22 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    31 Citations (Scopus)

  • Systematic generation of in vivo G protein-coupled receptor mutants in the rat

    Van Boxtel, R., Vroling, B., Toonen, P., Nijman, I. J., Van Roekel, H., Verheul, M., Baakman, C., Guryev, V., Vriend, G. & Cuppen, E., Oct 2011, In: Pharmacogenomics Journal. 11, 5, p. 326-336 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    18 Citations (Scopus)
  • 2010

    ENU mutagenesis to generate genetically modified rat models.

    van Boxtel, R., Gould, M. N., Cuppen, E. & Smits, B. M. G., 2010, In: Methods in molecular biology (Clifton, N.J.). 597, p. 151-167 17 p.

    Research output: Contribution to journal › Article › peer-review

    26 Citations (Scopus)

  • Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples

    Nijman, I. J., Mokry, M., Van Boxtel, R., Toonen, P., De Bruijn, E. & Cuppen, E., Nov 2010, In: Nature Methods. 7, 11, p. 913-915 3 p.

    Research output: Contribution to journal › Article › peer-review

    60 Citations (Scopus)

  • Rat traps: Filling the toolbox for manipulating the rat genome

    van Boxtel, R. & Cuppen, E., 29 Sept 2010, In: Genome Biology. 11, 9, 217.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    11 Citations (Scopus)
  • 2008

    Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

    Van Boxtel, R., Toonen, P. W., Verheul, M., Van Roekel, H. S., Nijman, I. J., Guryev, V. & Cuppen, E., 7 Oct 2008, In: BMC Genomics. 9, 460.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    26 Citations (Scopus)

  • Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis

    van Boxtel, R., Toonen, P. W., van Roekel, H. S., Verheul, M., Smits, B. M. G., Korving, J., de Bruin, A. & Cuppen, E., Jun 2008, In: Carcinogenesis. 29, 6, p. 1290-1297 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Citations (Scopus)