Ruben van Boxtel

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Ruben van Boxtel

 https://orcid.org/0000-0003-1285-2836
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20082022

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  • 2022

    Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene

    Allen, J., Rosendahl Huber, A., Pleguezuelos-Manzano, C., Puschhof, J., Wu, S., Wu, X., Boot, C., Saftien, A., O'Hagan, H. M., Wang, H., van Boxtel, R., Clevers, H. & Sears, C. L., 29 Jun 2022, In: Microbiology spectrum. 10, 3, p. e0105522

    Research output: Contribution to journal › Article › peer-review

    Open Access
    11 Citations (Scopus)

  • Different responses to DNA damage determine ageing differences between organs

    Vougioukalaki, M., Demmers, J., Vermeij, W. P., Baar, M., Bruens, S., Magaraki, A., Kuijk, E., Jager, M., Merzouk, S., Brandt, R. M. C., Kouwenberg, J., van Boxtel, R., Cuppen, E., Pothof, J. & Hoeijmakers, J. H. J., 1 Apr 2022, In: Aging cell. 21, 4, p. e13562

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Citations (Scopus)

  • Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

    Bollen, Y., Hageman, J. H., van Leenen, P., Derks, L. L. M., Ponsioen, B., Buissant des Amorie, J. R., Verlaan-Klink, I., van den Bos, M., Terstappen, L. W. M. M., van Boxtel, R. & Snippert, H. J. G., Jan 2022, In: PLoS biology. 20, 1, p. e3001527

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Citations (Scopus)

  • Elevated mutational age in blood of children treated for cancer contributes to therapy-related myeloid neoplasms

    Bertrums, E. J. M., Rosendahl Huber, A. K. M., de Kanter, J. K., Brandsma, A. M., van Leeuwen, A. J. C. N., Verheul, M., van den Heuvel-Eibrink, M. M., Oka, R., van Roosmalen, M. J., de Groot-Kruseman, H. A., Zwaan, C. M., Goemans, B. F. & van Boxtel, R., 1 Aug 2022, In: Cancer discovery. 12, 8, p. 1860-1872 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Citations (Scopus)

  • Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells in vivo

    Hasaart, K. A. L., Manders, F., Ubels, J., Verheul, M., van Roosmalen, M. J., Groenen, N. M., Oka, R., Kuijk, E., Lopes, S. M. C. D. S. & Boxtel, R. V., 18 Feb 2022, In: iScience. 25, 2, 103736.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Citations (Scopus)

  • Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

    Meister, M. T., Groot Koerkamp, M. J. A., de Souza, T., Breunis, W. B., Frazer-Mendelewska, E., Brok, M., DeMartino, J., Manders, F., Calandrini, C., Kerstens, H. H. D., Janse, A., Dolman, M. E. M., Eising, S., Langenberg, K. P. S., van Tuil, M., Knops, R. R. G., van Scheltinga, S. T., Hiemcke-Jiwa, L. S., Flucke, U., Merks, J. H. M., & 9 othersvan Noesel, M. M., Tops, B. B. J., Hehir-Kwa, J. Y., Kemmeren, P., Molenaar, J. J., van de Wetering, M., van Boxtel, R., Drost, J. & Holstege, F. C. P., 10 Oct 2022, In: EMBO molecular medicine. 14, 10, p. e16001 e16001.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Citations (Scopus)

  • Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells

    Manders, F., van Dinter, J. & van Boxtel, R., 22 Dec 2022, In: iScience. 25, 12, 105610.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Citation (Scopus)

  • MutationalPatterns: the one stop shop for the analysis of mutational processes

    Manders, F., Brandsma, A. M., de Kanter, J., Verheul, M., Oka, R., van Roosmalen, M. J., van der Roest, B., van Hoeck, A., Cuppen, E. & van Boxtel, R., 15 Feb 2022, In: BMC genomics. 23, 1, p. 134

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Citations (Scopus)

  • Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51

    Heijink, A. M., Stok, C., Porubsky, D., Manolika, E. M., de Kanter, J. K., Kok, Y. P., Everts, M., de Boer, H. R., Audrey, A., Bakker, F. J., Wierenga, E., Tijsterman, M., Guryev, V., Spierings, D. C. J., Knipscheer, P., van Boxtel, R., Ray Chaudhuri, A., Lansdorp, P. M. & van Vugt, M. A. T. M., Dec 2022, In: Nature Communications. 13, 1, 6722.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Citations (Scopus)

  • Whole-genome sequencing and mutational analysis of human cord-blood derived stem and progenitor cells

    Rosendahl Huber, A., van Leeuwen, A. J. C. N., Peci, F., de Kanter, J. K., Bertrums, E. J. M. & van Boxtel, R., 17 Jun 2022, In: STAR protocols. 3, 2, p. 101361 101361.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Citations (Scopus)
  • 2021

    Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients

    de Kanter, J. K., Peci, F., Bertrums, E., Rosendahl Huber, A., van Leeuwen, A., van Roosmalen, M. J., Manders, F., Verheul, M., Oka, R., Brandsma, A. M., Bierings, M., Belderbos, M. & van Boxtel, R., 7 Oct 2021, In: Cell stem cell. 28, 10, p. 1726-1739.e6

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Citations (Scopus)

  • Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma

    van den Boogaard, M. L., Oka, R., Hakkert, A., Schild, L., Ebus, M. E., van Gerven, M. R., Zwijnenburg, D. A., Molenaar, P., Hoyng, L. L., Dolman, M. E. M., Essing, A. H. W., Koopmans, B., Helleday, T., Drost, J., van Boxtel, R., Versteeg, R., Koster, J. & Molenaar, J. J., 7 Sept 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 36, e2007898118.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Citations (Scopus)

  • Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

    Geurts, M. H., de Poel, E., Pleguezuelos-Manzano, C., Oka, R., Carrillo, L., Andersson-Rolf, A., Boretto, M., Brunsveld, J. E., van Boxtel, R., Beekman, J. M. & Clevers, H., Oct 2021, In: Life science alliance. 4, 10, e202000940.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    49 Citations (Scopus)

  • In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

    Rothgangl, T., Dennis, M. K., Lin, P. J. C., Oka, R., Witzigmann, D., Villiger, L., Qi, W., Hruzova, M., Kissling, L., Lenggenhager, D., Borrelli, C., Egli, S., Frey, N., Bakker, N., Walker, J. A., Kadina, A. P., Victorov, D. V., Pacesa, M., Kreutzer, S., Kontarakis, Z., & 12 othersMoor, A., Jinek, M., Weissman, D., Stoffel, M., van Boxtel, R., Holden, K., Pardi, N., Thöny, B., Häberle, J., Tam, Y. K., Semple, S. C. & Schwank, G., Aug 2021, In: Nature biotechnology. 39, 8, p. 949-957 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    151 Citations (Scopus)

  • In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

    Villiger, L., Rothgangl, T., Witzigmann, D., Oka, R., Lin, P. J. C., Qi, W., Janjuha, S., Berk, C., Ringnalda, F., Beattie, M. B., Stoffel, M., Thöny, B., Hall, J., Rehrauer, H., van Boxtel, R., Tam, Y. K. & Schwank, G., Feb 2021, In: Nature biomedical engineering. 5, 2, p. 179-189 11 p.

    Research output: Contribution to journal › Article › peer-review

    45 Citations (Scopus)

  • Molecular characterization of Barrett's esophagus at single-cell resolution

    Busslinger, G. A., de Barbanson, B., Oka, R., Weusten, B. L. A., de Maat, M., van Hillegersberg, R., Brosens, L. A. A., van Boxtel, R., van Oudenaarden, A. & Clevers, H., 23 Nov 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 47

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Citations (Scopus)

  • Mutation signatures of pediatric acute myeloid leukemia and normal blood progenitors associated with differential patient outcomes

    Brandsma, A. M., Bertrums, E. J. M., van Roosmalen, M. J., Hofman, D. A., Oka, R., Verheul, M., Manders, F., Ubels, J., Belderbos, M. E. & van Boxtel, R., Sept 2021, In: Blood cancer discovery. 2, 5, p. 484-499 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer

    Lõhmussaar, K., Oka, R., Espejo Valle-Inclan, J., Smits, M. H. H., Wardak, H., Korving, J., Begthel, H., Proost, N., van de Ven, M., Kranenburg, O. W., Jonges, T. G. N., Zweemer, R. P., Veersema, S., van Boxtel, R. & Clevers, H., 5 Aug 2021, In: Cell Stem Cell. 28, 8, p. 1380-1396.e6

    Research output: Contribution to journal › Article › peer-review

    Open Access
    75 Citations (Scopus)

  • Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

    Nguyen, L., Jager, M., Lieshout, R., de Ruiter, P. E., Locati, M. D., Besselink, N., van der Roest, B., Janssen, R., Boymans, S., de Jonge, J., IJzermans, J. N. M., Doukas, M., Verstegen, M. M. A., van Boxtel, R., van der Laan, L. J. W., Cuppen, E. & Kuijk, E., 18 Nov 2021, In: Communications biology. 4, 1, p. 1301

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Citations (Scopus)

  • The mutational landscape of human somatic and germline cells

    Moore, L., Cagan, A., Coorens, T. H. H., Neville, M. D. C., Sanghvi, R., Sanders, M. A., Oliver, T. R. W., Leongamornlert, D., Ellis, P., Noorani, A., Mitchell, T. J., Butler, T. M., Hooks, Y., Warren, A. Y., Jorgensen, M., Dawson, K. J., Menzies, A., O'Neill, L., Latimer, C., Teng, M., & 8 othersvan Boxtel, R., Iacobuzio-Donahue, C. A., Martincorena, I., Heer, R., Campbell, P. J., Fitzgerald, R. C., Stratton, M. R. & Rahbari, R., Sept 2021, In: Nature. 597, 7876, p. 381-386 6 p.

    Research output: Contribution to journal › Article › peer-review

    103 Citations (Scopus)
  • 2020

    An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

    Calandrini, C., Schutgens, F., Oka, R., Margaritis, T., Candelli, T., Mathijsen, L., Ammerlaan, C., van Ineveld, R. L., Derakhshan, S., de Haan, S., Dolman, E., Lijnzaad, P., Custers, L., Begthel, H., Kerstens, H. H. D., Visser, L. L., Rookmaaker, M., Verhaar, M., Tytgat, G. A. M., Kemmeren, P., & 11 othersde Krijger, R. R., Al-Saadi, R., Pritchard-Jones, K., Kool, M., Rios, A. C., van den Heuvel-Eibrink, M. M., Molenaar, J. J., van Boxtel, R., Holstege, F. C. P., Clevers, H. & Drost, J., 11 Mar 2020, In: Nature communications. 11, 1, p. 1310 1310.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    152 Citations (Scopus)

  • CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

    Geurts, M. H., de Poel, E., Amatngalim, G. D., Oka, R., Meijers, F. M., Kruisselbrink, E., van Mourik, P., Berkers, G., de Winter-de Groot, K. M., Michel, S., Muilwijk, D., Aalbers, B. L., Mullenders, J., Boj, S. F., Suen, S. W. F., Brunsveld, J. E., Janssens, H. M., Mall, M. A., Graeber, S. Y., van Boxtel, R., & 3 othersvan der Ent, C. K., Beekman, J. M. & Clevers, H., 2 Apr 2020, In: Cell stem cell. 26, 4, p. 503-510.e7

    Research output: Contribution to journal › Article › peer-review

    118 Citations (Scopus)

  • Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis

    Hasaart, K. A. L., Manders, F., van der Hoorn, M-L., Verheul, M., Poplonski, T., Kuijk, E., de Sousa Lopes, S. M. C. & van Boxtel, R., 31 Jul 2020, In: Scientific Reports. 10, 1, p. 12991 12991.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    18 Citations (Scopus)

  • Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia

    Waanders, E., Gu, Z., Dobson, S. M., Antić, Ž., Crawford, J. C., Ma, X., Edmonson, M. N., Payne-Turner, D., van de Vorst, M., Jongmans, M. C. J., McGuire, I., Zhou, X., Wang, J., Shi, L., Pounds, S., Pei, D., Cheng, C., Song, G., Fan, Y., Shao, Y., & 23 othersRusch, M., McCastlain, K., Yu, J., van Boxtel, R., Blokzijl, F., Iacobucci, I., Roberts, K. G., Wen, J., Wu, G., Ma, J., Easton, J., Neale, G., Olsen, S. R., Nichols, K. E., Pui, C-H., Zhang, J., Evans, W. E., Relling, M. V., Yang, J. J., Thomas, P. G., Dick, J. E., Kuiper, R. & Mullighan, C. G., Jul 2020, In: Blood cancer discovery. 1, 1, p. 96-111 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

    Genomics England Research Consortium, Apr 2020, In: Nature. 580, 7802, p. 269-273 5 p.

    Research output: Contribution to journal › Article › peer-review

    470 Citations (Scopus)

  • Prime editing for functional repair in patient-derived disease models

    Schene, I. F., Joore, I. P., Oka, R., Mokry, M., van Vugt, A. H. M., van Boxtel, R., van der Doef, H. P. J., van der Laan, L. J. W., Verstegen, M. M. A., van Hasselt, P. M., Nieuwenhuis, E. E. S. & Fuchs, S. A., 23 Oct 2020, In: Nature communications. 11, 1, p. 5352 5352.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    108 Citations (Scopus)

  • The mutational impact of culturing human pluripotent and adult stem cells

    Kuijk, E., Jager, M., van der Roest, B., Locati, M. D., Van Hoeck, A., Korzelius, J., Janssen, R., Besselink, N., Boymans, S., van Boxtel, R. & Cuppen, E., 19 May 2020, In: Nature communications. 11, 1, p. 2493 2493.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    49 Citations (Scopus)
  • 2019

    Characterizing Mutational Load and Clonal Composition of Human Blood

    Huber, A. R., Manders, F., Oka, R. & van Boxtel, R., 11 Jul 2019, In: Journal of visualized experiments : JoVE. 2019, 149, e59846.

    Research output: Contribution to journal › Article › peer-review

    5 Citations (Scopus)

  • Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

    Jager, M., Blokzijl, F., Kuijk, E., Bertl, J., Vougioukalaki, M., Janssen, R., Besselink, N., Boymans, S., de Ligt, J., Pedersen, J. S., Hoeijmakers, J., Pothof, J., van Boxtel, R. & Cuppen, E., Jul 2019, In: Genome research. 29, 7, p. 1067-1077 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    49 Citations (Scopus)

  • Early divergence of mutational processes in human fetal tissues

    Kuijk, E., Blokzijl, F., Jager, M., Besselink, N., Boymans, S., Chuva de Sousa Lopes, S. M., van Boxtel, R. & Cuppen, E., May 2019, In: Science advances. 5, 5, p. eaaw1271 eaaw1271.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Citations (Scopus)

  • Oral mucosal organoids as a potential platform for personalized cancer therapy

    Driehuis, E., Kolders, S., Spelier, S., Lõhmussaar, K., Willems, S. M., Devriese, L. A., de Bree, R., de Ruiter, E. J., Korving, J., Begthel, H., van Es, J. H., Geurts, V., He, G. W., van Jaarsveld, R. H., Oka, R., Muraro, M. J., Vivié, J., Zandvliet, M. M. J. M., Hendrickx, A. P. A., Iakobachvili, N., & 8 othersSridevi, P., Kranenburg, O., van Boxtel, R., Kops, G. J. P. L., Tuveson, D. A., Peters, P. J., van Oudenaarden, A. & Clevers, H., Jul 2019, In: Cancer Discovery. 9, 7, p. 852-871 20 p.

    Research output: Contribution to journal › Article › peer-review

    190 Citations (Scopus)

  • Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

    Artegiani, B., van Voorthuijsen, L., Lindeboom, R. G. H., Seinstra, D., Heo, I., Tapia, P., López-Iglesias, C., Postrach, D., Dayton, T., Oka, R., Hu, H., van Boxtel, R., van Es, J. H., Offerhaus, J., Peters, P. J., van Rheenen, J., Vermeulen, M. & Clevers, H., 6 Jun 2019, In: Cell stem cell. 24, 6, p. 927-943.e6

    Research output: Contribution to journal › Article › peer-review

    117 Citations (Scopus)

  • Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development

    Govers, A. M. A. P., Wiggers, C. R. M., van Boxtel, R., Mokry, M., Nieuwenhuis, E. E. S., Creyghton, M. P., Bartels, M. & Coffer, P. J., Aug 2019, In: HemaSphere. 3, 4, p. e270 e270.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Citations (Scopus)

  • Tubuloids derived from human adult kidney and urine for personalized disease modeling

    Schutgens, F., Rookmaaker, M. B., Margaritis, T., Rios, A., Ammerlaan, C., Jansen, J., Gijzen, L., Vormann, M., Vonk, A., Viveen, M., Yengej, F. Y., Derakhshan, S., de Winter-de Groot, K. M., Artegiani, B., van Boxtel, R., Cuppen, E., Hendrickx, A. P. A., van den Heuvel-Eibrink, M. M., Heitzer, E., Lanz, H., & 7 othersBeekman, J., Murk, J-L., Masereeuw, R., Holstege, F., Drost, J., Verhaar, M. C. & Clevers, H., Mar 2019, In: Nature biotechnology. 37, 3, p. 303-313 11 p.

    Research output: Contribution to journal › Article › peer-review

    250 Citations (Scopus)
  • 2018

    A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

    Sachs, N., de Ligt, J., Kopper, O., Gogola, E., Bounova, G., Weeber, F., Balgobind, A. V., Wind, K., Gracanin, A., Begthel, H., Korving, J., van Boxtel, R., Duarte, A. A., Lelieveld, D., van Hoeck, A., Ernst, R. F., Blokzijl, F., Nijman, I. J., Hoogstraat, M., van de Ven, M., & 11 othersEgan, D. A., Zinzalla, V., Moll, J., Boj, S. F., Voest, E. E., Wessels, L., van Diest, P. J., Rottenberg, S., Vries, R. G. J., Cuppen, E. & Clevers, H., 11 Jan 2018, In: Cell. 172, 1-2, p. 373-386.e10

    Research output: Contribution to journal › Article › peer-review

    1009 Citations (Scopus)

  • Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

    Jager, M., Blokzijl, F., Sasselli, V., Boymans, S., Janssen, R., Besselink, N., Clevers, H., Van Boxtel, R. & Cuppen, E., 1 Jan 2018, In: Nature Protocols. 13, 1, p. 59-78 20 p.

    Research output: Contribution to journal › Article › peer-review

    40 Citations (Scopus)

  • Megakaryocyte lineage development is controlled by modulation of protein acetylation

    Bartels, M., Govers, A., Polak, R., Vervoort, S., Van Boxtel, R., Pals, C., Bierings, M., Van Solinge, W., Egberts, T., Nieuwenhuis, E., Mokry, M. & Coffer, P. J., Apr 2018, In: PLoS ONE. 13, 4, e0196400.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Citations (Scopus)

  • MutationalPatterns: Comprehensive genome-wide analysis of mutational processes

    Blokzijl, F., Janssen, R., van Boxtel, R. & Cuppen, E., 2018, In: Genome Medicine. 10, 1, 33.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    362 Citations (Scopus)

  • Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

    Osorio, F. G., Rosendahl Huber, A., Oka, R., Verheul, M., Patel, S. H., Hasaart, K., de la Fonteijne, L., Varela, I., Camargo, F. D. & van Boxtel, R., 27 Nov 2018, In: Cell reports. 25, 9, p. 2308-2316.e4

    Research output: Contribution to journal › Article › peer-review

    Open Access
    131 Citations (Scopus)

  • STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells

    Ribeiro, D., Melão, A., Van Boxtel, R., Santos, C. I., Silva, A., Silva, M. C., Cardoso, B. A., Coffer, P. J. & Barata, J. T., 11 Sept 2018, In: Blood Advances. 2, 17, p. 2199-2213 15 p.

    Research output: Contribution to journal › Article › peer-review

    56 Citations (Scopus)
  • 2017

    Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

    Fumagalli, A., Drost, J., Suijkerbuijk, S. J. E., van Boxtel, R., de Ligt, J., Offerhaus, G. J., Begthel, H., Beerling, E., Tan, E. H., Sansom, O. J., Cuppen, E., Clevers, H. & van Rheenen, J., 21 Mar 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. E2357-E2364

    Research output: Contribution to journal › Article › peer-review

    Open Access
    171 Citations (Scopus)

  • Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney

    Schutgens, F., Rookmaaker, M. B., Blokzijl, F., Van Boxtel, R., Vries, R., Cuppen, E., Verhaar, M. C. & Clevers, H., 26 Dec 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11190-E11198

    Research output: Contribution to journal › Article › peer-review

    16 Citations (Scopus)

  • Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

    Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., Nik-Zainal, S., Kuiper, R. P., Cuppen, E. & Clevers, H., 13 Oct 2017, In: Science. 358, 6360, p. 234-238 5 p.

    Research output: Contribution to journal › Article › peer-review

    274 Citations (Scopus)
  • 2016

    Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats

    Chen, X., Walther, F. J., van Boxtel, R., Laghmani, E. H., Sengers, R. M. A., Folkerts, G., Deruiter, M. C., Cuppen, E. & Wagenaar, G. T. M., 1 Mar 2016, In: Acta Physiologica. 216, 3, p. 358-375 18 p.

    Research output: Contribution to journal › Article › peer-review

    18 Citations (Scopus)

  • The role of the dopamine D1 receptor in social cognition: Studies using a novel genetic rat model

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    Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

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    8 Citations (Scopus)

  • Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

    D:A:D study group, the Royal Free Hospital Clinic Cohort, and the INSIGHT, SMART, and ESPRIT study groups, 1 Mar 2015, In: PLoS Medicine. 12, 3, e1001809.

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    Open Access
    103 Citations (Scopus)

  • Genomic landscape of rat strain and substrain variation

    Hermsen, R., de Ligt, J., Spee, W., Blokzijl, F., Schäfer, S., Adami, E., Boymans, S., Flink, S., van Boxtel, R., van der Weide, R. H., Aitman, T., Hübner, N., Simonis, M., Tabakoff, B., Guryev, V. & Cuppen, E., 12 Dec 2015, In: BMC Genomics. 16, 1, 357.

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    67 Citations (Scopus)

  • Long-term culture of genome-stable bipotent stem cells from adult human liver

    Huch, M., Gehart, H., Van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M. A., Ellis, E., Van Wenum, M., Fuchs, S. A., De Ligt, J., Van De Wetering, M., Sasaki, N., Boers, S. J., Kemperman, H., De Jonge, J., Ijzermans, J. N. M., Nieuwenhuis, E. E. S., Hoekstra, R., Strom, S., Vries, R. R. G., & 3 othersVan Der Laan, L. J. W., Cuppen, E. & Clevers, H., 15 Jan 2015, In: Cell. 160, 1-2, p. 299-312 14 p.

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    998 Citations (Scopus)