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2025
C12orf57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis
Jiang, R., Chouchane, M., Moey, C., Bunt, J., Li, J., Alkuraya, F., Alobeid, E., Richards, L., Ullian, E. & Sherr, E., 14 Mar 2025, In: bioRxiv : the preprint server for biology.Research output: Contribution to journal › Article
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Chromosome-specific aberrations, rather than general aneuploidy, may drive mouse embryonic stem cell-derived teratoma metastasis
Montilla-Rojo, J., Hillenius, S., Eleveld, T. F., Salvatori, D. C. F. & Looijenga, L. H. J., Jan 2025, In: Stem cell research & therapy. 16, 1, p. 181Research output: Contribution to journal › Article › peer-review
Open Access -
Cognitive and adaptive functioning outcomes after cancer diagnosis in early childhood: A systematic review
Beamish, J., Drijver, J. & Partanen, M., 5 May 2025, In: EJC Paediatric Oncology. 5Research output: Contribution to journal › Article › peer-review
Open Access -
Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant-Like Behavior
Montilla-Rojo, J., Eleveld, T. F., van Soest, M., Hillenius, S., Timmerman, D. M., Gillis, A. J. M., Roelen, B. A. J., Mummery, C. L., Looijenga, L. H. J. & Salvatori, D. C. F., Apr 2025, In: Advanced biology. 9, 4, p. e2400538Research output: Contribution to journal › Article › peer-review
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Emerging approaches to enhance human brain organoid physiology
Pagliaro, A., Artegiani, B. & Hendriks, D., Jun 2025, In: Trends in cell biology. 35, 6, p. 483-499 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Endothelial-to-mesenchymal transition gene signature derived from single-cell transcriptomics of human atherosclerotic tissue associates with stable plaque histological characteristics
Slenders, L., Wesseling, M., Wei, S., Boltjes, A., Kapteijn, D. M. C., van de Kraak, P., Depuydt, M. A. C., Prange, K. H. M., van den Dungen, N. A. M., Benavente, E. D., de Kleijn, D. P. V., de Borst, G. J., de Winther, M. P. J., den Ruijter, H. M., Owens, G. K., Pasterkamp, G. & Mokry, M., Jun 2025, In: Vascular pharmacology. 159, p. 107498Research output: Contribution to journal › Article › peer-review
Open Access -
Feasibility of single-shot multi-slice DENSE MRI at 7 T for strain tensor imaging in a paediatric population
van der Plas, M. C. E., van der Voort, E. C., Wijnen, J. P., Partanen, M. H. & Zwanenburg, J. J. M., 4 Apr 2025, In: Interface focus. 15, 1, p. 20240047Research output: Contribution to journal › Article › peer-review
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Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling
Pagliaro, A., Andreatta, F., Finger, R., Artegiani, B. & Hendriks, D., 6 Feb 2025, (E-pub ahead of print) In: Nature protocols.Research output: Contribution to journal › Article › peer-review
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Gonadal function and pathology in 17beta-HSD 3 and 5alpha-reductase deficiency
Boogers, L. S., Brüggenwirth, H. T., Wolffenbuttel, K. P., Hersmus, R., Bryce, J., Ahmed, S. F., Lucas-Herald, A. K., Baronio, F., Cools, M., Ellaithi, M., Globa, E., Güran, T., Hiort, O., Holterhus, P.-M., MсElreavey, K., Niedziela, M., Stancampiano, M. R., Tosun, B. G., van Bever, Y. & Oosterhuis, J. W. & 2 others, , 6 Jan 2025, In: European journal of endocrinology. 192, 1, p. 34-45 12 p.Research output: Contribution to journal › Article › peer-review
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Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers
Perotti, D., O'Sullivan, M. J., Walz, A. L., Davick, J., Al-Saadi, R., Benedetti, D. J., Brzezinski, J., Ciceri, S., Cost, N. G., Dome, J. S., Drost, J., Evageliou, N., Furtwängler, R., Graf, N., Maschietto, M., Mullen, E. A., Murphy, A. J., Ortiz, M. V., van der Beek, J. N. & Verschuur, A. & 6 others, , 2025, In: Nature reviews. Urology.Research output: Contribution to journal › Article › peer-review
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High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice
van Galen, I., Birkisdóttir, M. B., Ozinga, R. A., Brandt, R. M. C., Barnhoorn, S., Imholz, S., van Oostrom, C. T., van der Marel, R. W. G. N., Smit, K., Rijksen, Y. M. A., Reiling, E., van Steeg, H., Hoeijmakers, J. H. J., Dollé, M. E. T. & Vermeij, W. P., 22 May 2025, In: npj Metabolic Health and Disease. 3, 1, p. 20Research output: Contribution to journal › Article › peer-review
Open Access -
Hitting the mitotic spot of fibrolamellar carcinoma
Finger, R., Thomas, C., Hendriks, D. & Artegiani, B., 2025, In: Gut.Research output: Contribution to journal › Article › peer-review
Open Access -
Human Organoids as an Emerging Tool for Genome Screenings
Andreatta, F., Hendriks, D. & Artegiani, B., Jan 2025, In: Annual review of biomedical engineering. 27, 1, p. 157-183 27 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Improving accuracy of SUV estimates in paediatric oncology: Recommending against the use of body weight corrected SUV in [18F]FDG PET
de Vries, I. S. A., Lodema, S., Braat, A. J. A. T., Merks, J. H. M., van Rooij, R. & de Keizer, B., Jun 2025, In: European journal of nuclear medicine and molecular imaging. 52, 7, p. 2444-2451 8 p.Research output: Contribution to journal › Article › peer-review
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Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets
Wijnakker, J. J. A. P. M., van Son, G. J. F., Krueger, D., van de Wetering, W. J., Lopez-Iglesias, C., Schreurs, R., van Rijt, F., Lim, S., Lin, L., Peters, P. J., Isberg, R. R., Janda, C. Y., de Lau, W., Clevers, H. & Janda, C. Y., 7 Jan 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 1, p. e2420595121Research output: Contribution to journal › Article › peer-review
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Lactate controls cancer stemness and plasticity through epigenetic regulation
Nguyen, N. T. B., Gevers, S., Kok, R. N. U., Burgering, L. M., Neikes, H., Akkerman, N., Betjes, M. A., Ludikhuize, M. C., Gulersonmez, C., Stigter, E. C. A., Vercoulen, Y., Drost, J., Clevers, H., Vermeulen, M., van Zon, J. S., Tans, S. J., Burgering, B. M. T. & Rodríguez Colman, M. J., 1 Apr 2025, In: Cell Metabolism. 37, 4, p. 903-919.e10Research output: Contribution to journal › Article › peer-review
Open Access -
Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL
Cox, W., Dautzenberg, N., Dekker, L., Klenovsek, T., Cornel, A., van Hoesel, M., van Ingen Schenau, D. S., Bladergroen, R., Kuiper, R., van der Meer, L., Calkoen, F. G. & van Leeuwen, F., Feb 2025, In: Blood Neoplasia. 2, 1, p. 100060Research output: Contribution to journal › Article › peer-review
Open Access -
M&m: an RNA-seq based pan-cancer classifier for paediatric tumours
Wallis, F. S. A., Baker-Hernandez, J. L., van Tuil, M., van Hamersveld, C., Koudijs, M. J., Verwiel, E. T. P., Janse, A., Hiemcke-Jiwa, L. S., de Krijger, R. R., Kranendonk, M. E. G., Vermeulen, M. A., Wesseling, P., Flucke, U. E., de Haas, V., Luesink, M., Hoving, E. W., Vormoor, J. H., van Noesel, M. M., Hehir-Kwa, J. Y. & Tops, B. B. J. & 2 others, , Jan 2025, In: EBioMedicine. 111, p. 105506Research output: Contribution to journal › Article › peer-review
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Nephron-Sparing Surgery for Patients With Wilms Tumor, a Surgical Delphi Study Consensus Statement
Fitski, M., Bökkerink, G. M. J., Davidoff, A. M., Murphy, A. J., Abdelhafeez, A. H., Krauel, L., Fuchs, J., Pachl, M., de Campos Vieira Abib, S., Fernandez-Pineda, I., van de Ven, C. P., Wijnen, M., Klijn, A. J., Godzinski, J. & van der Steeg, A. F., Jan 2025, In: Pediatric Blood and Cancer.Research output: Contribution to journal › Article › peer-review
Open Access -
Neuroimaging of postoperative pediatric cerebellar mutism syndrome: a systematic review
Obdeijn, I. V., van Baarsen, K. M., Avula, S., Toescu, S., Lequin, M. H., Hoving, E. W. & Partanen, M., Jan 2025, In: Neuro-Oncology Advances. 7, 1, p. vdae212Research output: Contribution to journal › Article › peer-review
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Neuropsychological Performance and Its Predictors in the Early Treatment Phase of Non-CNS Pediatric Cancer
Huisman, M. H., Sanstra, S., Bos, D. P. A., Haveman, L. M., Grootenhuis, M. A., Aarsen, F. K. & Partanen, M., 2025, In: Pediatric blood & cancer. 72, 6, p. e31659Research output: Contribution to journal › Article › peer-review
Open Access -
Organoids from pluripotent stem cells and human tissues: When two cultures meet each other
Artegiani, B. & Hendriks, D., 24 Feb 2025, In: Developmental Cell. 60, 4, p. 493-511 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Overt and covert genetic causes of pediatric acute lymphoblastic leukemia: ACUTE LYMPHOBLASTIC LEUKEMIA
Stoltze, U., Junk, S. V., Byrjalsen, A., Cavé, H., Cazzaniga, G., Elitzur, S., Fronkova, E., Hjalgrim, L. L., Kuiper, R. P., Lundgren, L., Mescher, M., Mikkelsen, T., Pastorczak, A., Strullu, M., Trka, J., Wadt, K., Izraeli, S., Borkhardt, A. & Schmiegelow, K., May 2025, In: Leukemia. 39, 5, p. 1031-1045 15 p.Research output: Contribution to journal › Article › peer-review
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Predisposition Footprints in the Somatic Genome of Wilms Tumors
Treger, T. D., Wegert, J., Wenger, A., Coorens, T. H. H., Al-Saadi, R., Kemps, P. G., Kennedy, J., Parks, C., Anderson, N. D., Hodder, A., Letunovska, A., Jung, H., Ogbonnah, T., Trinh, M. K., Lee-Six, H., Morcrette, G., van den Heuvel-Eibrink, M. M., Drost, J., van Boxtel, R. & Bertrums, E. J. M. & 15 others, , 7 Feb 2025, In: Cancer discovery. 15, 2, p. 286-298 13 p.Research output: Contribution to journal › Article › peer-review
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Searching for the origin of human brain tumours
Hendriks, D. & Artegiani, B., 2025, In: Nature Reviews Genetics.Research output: Contribution to journal › Article › peer-review
Open Access -
Secondary lesions and sensitivity to signaling inhibitors in iAMP21 acute lymphoblastic leukemia
Hormann, F. M., Østergaard, A., van den Broek, S., Boeree, A., van de Ven, C., Escherich, G., Sonneveld, E., Boer, J. M. & den Boer, M. L., Jan 2025, In: HemaSphere. 9, 1, p. e70069Research output: Contribution to journal › Article › peer-review
Open Access -
Short-term fasting before living kidney donation has an immune-modulatory effect
Oudmaijer, C. A. J., Komninos, D. S. J., Ozinga, R. A., Smit, K., Rozendaal, N. E. M., Hoeijmakers, J. H. J., Vermeij, W. P., Aerts, J. G. J. V., IJzermans, J. N. M. & Willemsen, M., 2025, In: Frontiers in immunology. 16, p. 1488324Research output: Contribution to journal › Article › peer-review
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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B-cell Lymphoma
Göbel, C., Niccolai, R., de Groot, M. H. P., Jayachandran, J., Traets, J., Kloosterman, D. J., Gregoricchio, S., Morris, B., Kreft, M., Song, J.-Y., Azarang, L., Kasa, E., Oskam, N., de Groot, D., Hoekman, L., Bleijerveld, O., Kersten, M. J., Aslam, M. A., van Leeuwen, F. & Jacobs, H., 17 Apr 2025, In: Blood. 145, 16, p. 1802-1813 12 p.Research output: Contribution to journal › Article › peer-review
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Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening
Götz, L., Wegert, J., Paikari, A., Appenzeller, S., Bausenwein, S., Vokuhl, C., Treger, T. D., Drost, J., Linderkamp, C., Schneider, D. T., Ernestus, K., Warman, S. W., Fuchs, J., Welter, N., Graf, N., Behjati, S., Furtwängler, R. & Gessler, M., Jan 2025, In: Translational oncology. 52, p. 102263Research output: Contribution to journal › Article › peer-review
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2024
A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test
Touwslager, R. N. H., Zwaan, C. M., Bakker, B., Lentjes, E. G. W. M., Looijenga, L. H. J. & van Santen, H. M., 27 May 2024, In: Journal of Pediatric Endocrinology and Metabolism. 37, 5, p. 482-485 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A comprehensive overview of liquid biopsy applications in pediatric solid tumors
Janssen, F., Lak, N., Janda, C. Y., Kester, L., Meister, M., Merks, H., van den Heuvel - Eibrink, M., van Noesel, M. M., Zsiros, J., Tytgat, L. & Looijenga, L. H. J., 3 Aug 2024, In: NPJ Precision Oncology. 8, 1, p. 172 https://doi.org/10.1038/s41698-024-00657-z.Research output: Contribution to journal › Review article › peer-review
Open Access -
Alkylating agents-induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front
Sriram, S., Macedo, T., Mavinkurve-Groothuis, A. M. C., van de Wetering, M. & Looijenga, L. H. J., 4 Jul 2024, In: Clinical and Translational Science.Research output: Contribution to journal › Review article › peer-review
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A longitudinal evaluation of smell and taste function in children with cancer during and after treatment with chemotherapy
van den Brink, M., Havermans, R., Fiocco, M. & Tissing, W., Jan 2024, In: Appetite. 193Research output: Contribution to journal › Article › peer-review
Open Access -
A multidimensional analysis reveals distinct immune phenotypes and the composition of immune aggregates in pediatric acute myeloid leukemia
Koedijk, J. B., van der Werf, I., Penter, L., Vermeulen, M. A., Barneh, F., Perzolli, A., Meesters-Ensing, J. I., Metselaar, D. S., Margaritis, T., Fiocco, M., de Groot-Kruseman, H. A., Moeniralam, R., Bang Christensen, K., Porter, B., Pfaff, K., Garcia, J. S., Rodig, S. J., Wu, C. J., Hasle, H. & Nierkens, S. & 4 others, , Nov 2024, In: Leukemia. 38, 11, p. 2332-2343 12 p.Research output: Contribution to journal › Article › peer-review
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A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery
Jeremiasse, B., van Ineveld, R. L., Bok, V., Kleinnijenhuis, M., de Blank, S., Alieva, M., Johnson, H. R., van Vliet, E. J., Zeeman, A. L., Wellens, L. M., Llibre-Palomar, G., Barrera Román, M., Di Maggio, A., Dekkers, J. F., Oliveira, S., Vahrmeijer, A. L., Molenaar, J. J., Wijnen, M. H., van der Steeg, A. F. & Wehrens, E. J. & 1 others, , Jul 2024, In: EMBO molecular medicine. 16, 7, p. 1495-1514 20 p.Research output: Contribution to journal › Article
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Are measurable residual disease results after consolidation therapy useful in children with acute lymphoblastic leukemia?
Stutterheim, J., van der Waarden, R., de Groot-Kruseman, H. A., Sonneveld, E., de Haas, V., Dandis, R., van der Schoot, C. E., van der Velden, V. H. J. & Pieters, R., Nov 2024, In: Leukemia. 38, 11, p. 2376-2381 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Artificial and natural interventions for chemotherapy- and / or radiotherapy-induced cognitive impairment: A systematic review of animal studies
Kuil, L. E., Varkevisser, T. M. C. K., Huisman, M. H., Jansen, M., Bunt, J., Compter, A., Ket, H., Schagen, S. B., Meeteren, A. Y. N.S.-V. & Partanen, M., Feb 2024, In: Neuroscience and Biobehavioral Reviews. 157, p. 105514Research output: Contribution to journal › Review article › peer-review
Open Access -
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans
Benavente, E. D., Hartman, R. J. G., Sakkers, T. R., Wesseling, M., Sloots, Y., Slenders, L., Boltjes, A., Mol, B. M., de Borst, G. J., de Kleijn, D. P. V., Prange, K. H. M., de Winther, M. P. J., Kuiper, J., Civelek, M., van der Laan, S. W., Horvath, S., Onland-Moret, C., Mokry, M., Pasterkamp, G. & den Ruijter, H. M., Jun 2024, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 44, 6, p. 1419-1431 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Author Correction: A comprehensive overview of liquid biopsy applications in pediatric solid tumors
Janssen, F. W., Lak, N. S. M., Janda, C. Y., Kester, L. A., Meister, M. T., Merks, J. H. M., van den Heuvel-Eibrink, M. M., van Noesel, M. M., Zsiros, J., Tytgat, G. A. M. & Looijenga, L. H. J., 25 Sept 2024, In: NPJ precision oncology. 8, 1, p. 210Research output: Contribution to journal › Article › peer-review
Open Access -
B-cell precursor acute lymphoblastic leukemia elicits an interferon-α/β response in bone marrow-derived mesenchymal stroma
Smeets, M. W. E., Steeghs, E. M. P., Orsel, J., Stalpers, F., Vermeeren, M. M. P., Veltman, C. H. J., Slenders, L., Nierkens, S., Van de Ven, C. & Den Boer, M. L., 1 Jul 2024, In: Haematologica. 109, 7, p. 2073-2084 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Behav3d: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response
Alieva, M., Barrera Román, M., de Blank, S., Petcu, D., Zeeman, A. L., Dautzenberg, N. M. M., Cornel, A. M., van de Ven, C., Pieters, R., den Boer, M. L., Nierkens, S., Calkoen, F. G. J., Clevers, H., Kuball, J., Sebestyén, Z., Wehrens, E. J., Dekkers, J. F. & Rios, A. C., Jul 2024, In: Nature protocols. 19, 7, p. 2052-2084 33 p.Research output: Contribution to journal › Article › peer-review
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Bevacizumab-containing treatment for relapsed or refractory Wilms tumor
Al-Jilaihawi, S., Spreafico, F., Mavinkurve-Groothuis, A., Drost, J., Perotti, D., Koenig, C. & Brok, J., Sept 2024, In: Expert review of anticancer therapy. 24, 9, p. 837-843 7 p.Research output: Contribution to journal › Article › peer-review
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Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Kimura, S., Park, C. S., Montefiori, L. E., Iacobucci, I., Pölönen, P., Gao, Q., Arnold, E. D., Attarbaschi, A., Brown, A., Buldini, B., Caldwell, K. J., Chang, Y., Chen, C., Cheng, C., Cheng, Z., Choi, J., Conter, V., Crews, K. R., de Groot-Kruseman, H. A. & Deguchi, T. & 66 others, , 4 Oct 2024, In: Cancer discovery. 14, 10, p. 1838-1859 22 p.Research output: Contribution to journal › Article › peer-review
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Bone health in childhood low grade glioma; an understudied problem
van Roessel, I. M. A. A., Gorter, J., Bakker, B., Lequin, M. H., van der Lugt, J., Meijer, L., Schouten-van Meeteren, A. Y. N., van Santen, H. M. & van den Heuvel - Eibrink, M., 1 Oct 2024, In: Endocrine connections. 13, 10Research output: Contribution to journal › Article › peer-review
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Bridging the gap: advancing cancer cell culture to reveal key metabolic targets
Kes, M. M. G., Berkers, C. R. & Drost, J., 2024, In: Frontiers in Oncology. 14, p. 1480613Research output: Contribution to journal › Article › peer-review
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Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2
Planchais , C. & Chalopin, B., 19 Jul 2024, In: iScience. 27, 7, p. 110354Research output: Contribution to journal › Article › peer-review
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Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
Ramirez, C. F. A., Taranto, D., Ando-Kuri, M., de Groot, M. H. P., Tsouri, E., Huang, Z., de Groot, D., Kluin, R. J. C., Kloosterman, D. J., Verheij, J., Xu, J., Vegna, S. & Akkari, L., 22 Mar 2024, In: Nature communications. 15, 1, p. 2581Research output: Contribution to journal › Article › peer-review
Open Access -
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
Molina, O., Ortega-Sabater, C., Thampi, N., Fernández-Fuentes, N., Guerrero-Murillo, M., Martínez-Moreno, A., Vinyoles, M., Velasco-Hernández, T., Bueno, C., Trincado, J. L., Granada, I., Campos, D., Giménez, C., Boer, J. M., den Boer, M. L., Calvo, G. F., Camós, M., Fuster, J.-L., Velasco, P. & Ballerini, P. & 6 others, , Jan 2024, In: EMBO molecular medicine. 16, 1, p. 64-92 29 p., 38177531.Research output: Contribution to journal › Article › peer-review
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Clinical Application and Further Development of Augmented Reality Guidance for the Surgical Localization of Pediatric Chest Wall Tumors
van der Woude, R., Fitski, M., van der Zee, J. M., van de Ven, C. P., Bökkerink, G. M. J., Wijnen, M. H. W. A., Meulstee, J. W., van Doormaal, T. P. C., Siepel, F. J. & van der Steeg, A. F. W., Jan 2024, In: Journal of Pediatric Surgery. 59, 8, p. 1549-1555 7 p.Research output: Contribution to journal › Article › peer-review
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Clinical Characterization of a National Cohort of Patients With Germline WT1 Variants Including Late-Onset Phenotypes
van Peer, S. E., Kuiper, R. P., Hol, J. A., Egging, S., van der Zwaag, B., Lilien, M. R., Lombardi, M. P., van den Heuvel-Eibrink, M. M. & Jongmans, M. C. J., Dec 2024, In: Kidney international reports. 9, 12, p. 3570-3579 10 p.Research output: Contribution to journal › Article › peer-review