18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma

Marc H A Jansen; Reina W Kloet; Dannis G van Vuurden; Sophie Em Veldhuijzen van Zanten; Birgit I Witte; Serge Goldman; W Peter Vandertop; Emile Fi Comans; Otto S Hoekstra; Ronald Boellaard; Gert-Jan Jl Kaspers

doi:10.1186/2191-219X-4-8

18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma

Marc H A Jansen, Reina W Kloet, Dannis G van Vuurden, Sophie Em Veldhuijzen van Zanten, Birgit I Witte, Serge Goldman, W Peter Vandertop, Emile Fi Comans, Otto S Hoekstra, Ronald Boellaard, Gert-Jan Jl Kaspers

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

BACKGROUND: Positron emission tomography (PET) scanning with [18 F]fluorodeoxyglucose (18 F-FDG) is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma (DIPG) is still unclear. For interpretation of 18 F-FDG PET results in DIPG, uptake values of the normal pons of children of increasing ages are mandatory. The aim of this study was to determine 18 F-FDG standard uptake value ratios (SUVr) of the normal pons and to compare these to those of DIPG.

METHODS: We studied 36 subjects with a normal, non-affected pons (aged 5 to 23 years) and 6 patients with DIPG (aged 4 to 17 years) who underwent 18 F-FDG PET scanning. Magnetic resonance imaging (MRI) was co-registered to define the regions of interest. SUVr and SUVrmax for the pons/cerebellum (SUVrp/c) and the pons/occipital lobe (SUVrp/o) were calculated. Independent-samples t tests and Mann-Whitney U tests were used to compare the mean SUVr and Pearson's test for correlations.

RESULTS: For the normal pons, mean SUVrp/c and SUVrp/o were 0.65 (±0.054) and 0.51 (±0.056), respectively. No significant correlations were found between the SUVr of the normal pons and sex, age, nor pontine volume. A modest but statistically significant correlation was found between SUVr and post-injection time acquisition timing. For DIPG, mean SUVrp/c and SUVrp/o were 0.74 (±0.20) and 0.65 (±0.30), respectively, while mean SUVrp(max)/c and SUVrp(max)/o were 1.95 (±0.48) and 1.81 (±0.20), respectively.

CONCLUSION: The SUVr of the unaffected pons are strikingly constant between children, irrespective of sex and age, and can therefore be well used as a reference value for 18 F-FDG PET studies in DIPG.

Original language	English
Article number	8
Pages (from-to)	8
Number of pages	7
Journal	EJNMMI research
Volume	4
Issue number	1
DOIs	https://doi.org/10.1186/2191-219X-4-8
Publication status	Published - 28 Jan 2014
Externally published	Yes

Keywords

Brain neoplasms
Pons
Pontine glioma
Positron emission tomography
Reference values

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10.1186/2191-219X-4-8

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Jansen, M. H. A., Kloet, R. W., van Vuurden, D. G., Veldhuijzen van Zanten, S. E., Witte, B. I., Goldman, S., Vandertop, W. P., Comans, E. F., Hoekstra, O. S., Boellaard, R., & Kaspers, G.-J. J. (2014). 18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma. EJNMMI research, 4(1), 8. Article 8. https://doi.org/10.1186/2191-219X-4-8

@article{cedb5d140a834829b900d0b6ab7d099e,

title = "18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma",

abstract = "BACKGROUND: Positron emission tomography (PET) scanning with [18 F]fluorodeoxyglucose (18 F-FDG) is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma (DIPG) is still unclear. For interpretation of 18 F-FDG PET results in DIPG, uptake values of the normal pons of children of increasing ages are mandatory. The aim of this study was to determine 18 F-FDG standard uptake value ratios (SUVr) of the normal pons and to compare these to those of DIPG.METHODS: We studied 36 subjects with a normal, non-affected pons (aged 5 to 23 years) and 6 patients with DIPG (aged 4 to 17 years) who underwent 18 F-FDG PET scanning. Magnetic resonance imaging (MRI) was co-registered to define the regions of interest. SUVr and SUVrmax for the pons/cerebellum (SUVrp/c) and the pons/occipital lobe (SUVrp/o) were calculated. Independent-samples t tests and Mann-Whitney U tests were used to compare the mean SUVr and Pearson's test for correlations.RESULTS: For the normal pons, mean SUVrp/c and SUVrp/o were 0.65 (±0.054) and 0.51 (±0.056), respectively. No significant correlations were found between the SUVr of the normal pons and sex, age, nor pontine volume. A modest but statistically significant correlation was found between SUVr and post-injection time acquisition timing. For DIPG, mean SUVrp/c and SUVrp/o were 0.74 (±0.20) and 0.65 (±0.30), respectively, while mean SUVrp(max)/c and SUVrp(max)/o were 1.95 (±0.48) and 1.81 (±0.20), respectively.CONCLUSION: The SUVr of the unaffected pons are strikingly constant between children, irrespective of sex and age, and can therefore be well used as a reference value for 18 F-FDG PET studies in DIPG.",

keywords = "Brain neoplasms, Pons, Pontine glioma, Positron emission tomography, Reference values",

author = "Jansen, \{Marc H A\} and Kloet, \{Reina W\} and \{van Vuurden\}, \{Dannis G\} and \{Veldhuijzen van Zanten\}, \{Sophie Em\} and Witte, \{Birgit I\} and Serge Goldman and Vandertop, \{W Peter\} and Comans, \{Emile Fi\} and Hoekstra, \{Otto S\} and Ronald Boellaard and Kaspers, \{Gert-Jan Jl\}",

note = "Funding Information: DIPG research is funded by the Semmy and Egbers foundations. The sponsors had no role in the preparation and execution of the study and/or manuscript. ",

year = "2014",

month = jan,

day = "28",

doi = "10.1186/2191-219X-4-8",

language = "English",

volume = "4",

pages = "8",

journal = "EJNMMI research",

issn = "2191-219X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

Jansen, MHA, Kloet, RW, van Vuurden, DG , Veldhuijzen van Zanten, SE, Witte, BI, Goldman, S, Vandertop, WP, Comans, EF, Hoekstra, OS, Boellaard, R & Kaspers, G-JJ 2014, '18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma', EJNMMI research, vol. 4, no. 1, 8, pp. 8. https://doi.org/10.1186/2191-219X-4-8

TY - JOUR

T1 - 18 F-FDG PET standard uptake values of the normal pons in children

T2 - establishing a reference value for diffuse intrinsic pontine glioma

AU - Jansen, Marc H A

AU - Kloet, Reina W

AU - van Vuurden, Dannis G

AU - Veldhuijzen van Zanten, Sophie Em

AU - Witte, Birgit I

AU - Goldman, Serge

AU - Vandertop, W Peter

AU - Comans, Emile Fi

AU - Hoekstra, Otto S

AU - Boellaard, Ronald

AU - Kaspers, Gert-Jan Jl

N1 - Funding Information: DIPG research is funded by the Semmy and Egbers foundations. The sponsors had no role in the preparation and execution of the study and/or manuscript.

PY - 2014/1/28

Y1 - 2014/1/28

N2 - BACKGROUND: Positron emission tomography (PET) scanning with [18 F]fluorodeoxyglucose (18 F-FDG) is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma (DIPG) is still unclear. For interpretation of 18 F-FDG PET results in DIPG, uptake values of the normal pons of children of increasing ages are mandatory. The aim of this study was to determine 18 F-FDG standard uptake value ratios (SUVr) of the normal pons and to compare these to those of DIPG.METHODS: We studied 36 subjects with a normal, non-affected pons (aged 5 to 23 years) and 6 patients with DIPG (aged 4 to 17 years) who underwent 18 F-FDG PET scanning. Magnetic resonance imaging (MRI) was co-registered to define the regions of interest. SUVr and SUVrmax for the pons/cerebellum (SUVrp/c) and the pons/occipital lobe (SUVrp/o) were calculated. Independent-samples t tests and Mann-Whitney U tests were used to compare the mean SUVr and Pearson's test for correlations.RESULTS: For the normal pons, mean SUVrp/c and SUVrp/o were 0.65 (±0.054) and 0.51 (±0.056), respectively. No significant correlations were found between the SUVr of the normal pons and sex, age, nor pontine volume. A modest but statistically significant correlation was found between SUVr and post-injection time acquisition timing. For DIPG, mean SUVrp/c and SUVrp/o were 0.74 (±0.20) and 0.65 (±0.30), respectively, while mean SUVrp(max)/c and SUVrp(max)/o were 1.95 (±0.48) and 1.81 (±0.20), respectively.CONCLUSION: The SUVr of the unaffected pons are strikingly constant between children, irrespective of sex and age, and can therefore be well used as a reference value for 18 F-FDG PET studies in DIPG.

AB - BACKGROUND: Positron emission tomography (PET) scanning with [18 F]fluorodeoxyglucose (18 F-FDG) is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma (DIPG) is still unclear. For interpretation of 18 F-FDG PET results in DIPG, uptake values of the normal pons of children of increasing ages are mandatory. The aim of this study was to determine 18 F-FDG standard uptake value ratios (SUVr) of the normal pons and to compare these to those of DIPG.METHODS: We studied 36 subjects with a normal, non-affected pons (aged 5 to 23 years) and 6 patients with DIPG (aged 4 to 17 years) who underwent 18 F-FDG PET scanning. Magnetic resonance imaging (MRI) was co-registered to define the regions of interest. SUVr and SUVrmax for the pons/cerebellum (SUVrp/c) and the pons/occipital lobe (SUVrp/o) were calculated. Independent-samples t tests and Mann-Whitney U tests were used to compare the mean SUVr and Pearson's test for correlations.RESULTS: For the normal pons, mean SUVrp/c and SUVrp/o were 0.65 (±0.054) and 0.51 (±0.056), respectively. No significant correlations were found between the SUVr of the normal pons and sex, age, nor pontine volume. A modest but statistically significant correlation was found between SUVr and post-injection time acquisition timing. For DIPG, mean SUVrp/c and SUVrp/o were 0.74 (±0.20) and 0.65 (±0.30), respectively, while mean SUVrp(max)/c and SUVrp(max)/o were 1.95 (±0.48) and 1.81 (±0.20), respectively.CONCLUSION: The SUVr of the unaffected pons are strikingly constant between children, irrespective of sex and age, and can therefore be well used as a reference value for 18 F-FDG PET studies in DIPG.

KW - Brain neoplasms

KW - Pons

KW - Pontine glioma

KW - Positron emission tomography

KW - Reference values

UR - https://www.scopus.com/pages/publications/84895782584

U2 - 10.1186/2191-219X-4-8

DO - 10.1186/2191-219X-4-8

M3 - Article

C2 - 24472395

SN - 2191-219X

VL - 4

SP - 8

JO - EJNMMI research

JF - EJNMMI research

IS - 1

M1 - 8

ER -

18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma

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Keywords

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