Abstract
OBJECTIVES: Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test.
CASE PRESENTATION: A workup was performed in a 14-year-old girl with a positive pregnancy test. She was diagnosed with stage IV neuroblastoma of the left adrenal gland at the age of 4 years. She received extensive treatment, including alkylating agents, and had been diagnosed with premature ovarian insufficiency. An LH/hCG suppression test was performed using high dose 17 bèta-estradiol: hCG levels normalized.
CONCLUSIONS: The pregnancy test was false-positive due to production of low amounts of hCG by the pituitary gland as a result of high LH concentrations following premature ovarian insufficiency. It may be helpful to perform the LH/hCG suppression test to prove pituitary origin of the hCG overproduction.
| Original language | English |
|---|---|
| Pages (from-to) | 482-485 |
| Number of pages | 4 |
| Journal | Journal of Pediatric Endocrinology and Metabolism |
| Volume | 37 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 May 2024 |
Keywords
- childhood cancer survivors
- human chorionic gonadotropin
- pituitary gland
- premature ovarian insufficiency
- teenage pregnancy
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