Abstract
A 40-year-old woman presented with blurred vision and diplopia, followed by slowly progressive left-sided motor and sensory disturbances. She also suffered from memory loss and had mild spatial and temporal disorientation. A T2-weighted MRI showed a large area of high signal intensity in the periventricular white matter of the right more than the left occipital region and the corpus callosum, without enhancement on T1-weighted images after gadolinium administration and without mass effect. A stereotacticbiopsy of the intracerebral lesion showed blast-like neoplastic cells within a mononuclear infiltrate. No diagnosis could be made based on morphology and immunohistochemistry using a large series of markers. However, based on positive OCT3/4 nuclear staining, the tumor was diagnosed as a germinoma (seminoma of the brain). The patient was treated accordingly and her condition improved, although focal deficits remained.
Original language | English |
---|---|
Pages (from-to) | 103-4, 142 |
Number of pages | 2 |
Journal | Brain Pathology |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2008 |
Externally published | Yes |
Keywords
- Adult
- Biomarkers, Tumor/analysis
- Brain Neoplasms/metabolism
- Cerebrum/metabolism
- Diagnosis, Differential
- Disease Progression
- Early Diagnosis
- Female
- Germinoma/metabolism
- Humans
- Magnetic Resonance Imaging
- Neoplasm Invasiveness/diagnostic imaging
- Neoplasm Recurrence, Local
- Nerve Fibers, Myelinated/metabolism
- Neurosurgical Procedures
- Octamer Transcription Factor-3/analysis
- Predictive Value of Tests
- Radiography
- Remission Induction
- Vision, Low/etiology
- Visual Pathways/pathology