A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Bianca F. Goemans; Christian M. Zwaan; Dirk Reinhardt; Brenda E.S. Gibson; K. Hählen; Gert Jan L. Kaspers

A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Bianca F. Goemans
, Christian M. Zwaan
, Dirk Reinhardt
, Brenda E.S. Gibson
, K. Hählen
, Gert Jan L. Kaspers

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

Original language	English
Pages (from-to)	1573-1574
Number of pages	2
Journal	Haematologica
Volume	91
Issue number	11
Publication status	Published - Nov 2006
Externally published	Yes

Keywords

Cardiotoxicity
Drug sensitivity
Liposomal daunombicin
Pediatric acute leukemia

Cite this

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title = "A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia",

abstract = "Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.",

keywords = "Cardiotoxicity, Drug sensitivity, Liposomal daunombicin, Pediatric acute leukemia",

author = "Goemans, \{Bianca F.\} and Zwaan, \{Christian M.\} and Dirk Reinhardt and Gibson, \{Brenda E.S.\} and K. H{\"a}hlen and Kaspers, \{Gert Jan L.\}",

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T1 - A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

AU - Goemans, Bianca F.

AU - Zwaan, Christian M.

AU - Reinhardt, Dirk

AU - Gibson, Brenda E.S.

AU - Hählen, K.

AU - Kaspers, Gert Jan L.

PY - 2006/11

Y1 - 2006/11

N2 - Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

AB - Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

KW - Cardiotoxicity

KW - Drug sensitivity

KW - Liposomal daunombicin

KW - Pediatric acute leukemia

UR - https://www.scopus.com/pages/publications/33750933843

M3 - Article

C2 - 17043024

AN - SCOPUS:33750933843

SN - 0390-6078

VL - 91

SP - 1573

EP - 1574

JO - Haematologica

JF - Haematologica

IS - 11

ER -

A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Abstract

Keywords

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Cite this