A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

Helen H.N. Yan; Hoi Cheong Siu; Simon Law; Siu Lun Ho; Sarah S.K. Yue; Wai Yin Tsui; Dessy Chan; April S. Chan; Stephanie Ma; Ka On Lam; Sina Bartfeld; Alice H.Y. Man; Bernard C.H. Lee; Annie S.Y. Chan; Jason W.H. Wong; Priscilla S.W. Cheng; Anthony K.W. Chan; Jiangwen Zhang; Jue Shi; Xiaodan Fan; Dora L.W. Kwong; Tak W. Mak; Siu Tsan Yuen; Hans Clevers; Suet Yi Leung

doi:10.1016/j.stem.2018.09.016

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

Helen H.N. Yan
, Hoi Cheong Siu
, Simon Law
, Siu Lun Ho
, Sarah S.K. Yue
, Wai Yin Tsui
, Dessy Chan
, April S. Chan
, Stephanie Ma
, Ka On Lam
, Sina Bartfeld
, Alice H.Y. Man
, Bernard C.H. Lee
, Annie S.Y. Chan
, Jason W.H. Wong
, Priscilla S.W. Cheng
, Anthony K.W. Chan
, Jiangwen Zhang
, Jue Shi
, Xiaodan Fan

Dora L.W. Kwong, Tak W. Mak, Siu Tsan Yuen, Hans Clevers, Suet Yi Leung

Group Clevers

Research output: Contribution to journal › Article › peer-review

627 Citations (Scopus)

Abstract

Leung and colleagues established a biobank of patient-derived gastric cancer organoids that encompasses a diverse array of subtypes and maintained long-term similarity to the original tumors. They used the organoids to perform large-scale drug screening that identified potential target drugs and could guide patient drug selection.

Original language	English
Pages (from-to)	882-897.e11
Journal	Cell stem cell
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2018.09.016
Publication status	Published - 6 Dec 2018

Keywords

ARHGAP fusions
EBV genome
RHOA mutations
biobank
drug screening
gastric cancer
heterogeneity
organoid culture
transcriptome sequencing
whole-exome sequencing

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10.1016/j.stem.2018.09.016

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Yan, H. H. N., Siu, H. C., Law, S., Ho, S. L., Yue, S. S. K., Tsui, W. Y., Chan, D., Chan, A. S., Ma, S., Lam, K. O., Bartfeld, S., Man, A. H. Y., Lee, B. C. H., Chan, A. S. Y., Wong, J. W. H., Cheng, P. S. W., Chan, A. K. W., Zhang, J., Shi, J., ... Leung, S. Y. (2018). A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening. Cell stem cell, 23(6), 882-897.e11. https://doi.org/10.1016/j.stem.2018.09.016

@article{b5cb0ebebea948aeab2f0597c15cfc16,

title = "A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening",

abstract = "Leung and colleagues established a biobank of patient-derived gastric cancer organoids that encompasses a diverse array of subtypes and maintained long-term similarity to the original tumors. They used the organoids to perform large-scale drug screening that identified potential target drugs and could guide patient drug selection.",

keywords = "ARHGAP fusions, EBV genome, RHOA mutations, biobank, drug screening, gastric cancer, heterogeneity, organoid culture, transcriptome sequencing, whole-exome sequencing",

author = "Yan, \{Helen H.N.\} and Siu, \{Hoi Cheong\} and Simon Law and Ho, \{Siu Lun\} and Yue, \{Sarah S.K.\} and Tsui, \{Wai Yin\} and Dessy Chan and Chan, \{April S.\} and Stephanie Ma and Lam, \{Ka On\} and Sina Bartfeld and Man, \{Alice H.Y.\} and Lee, \{Bernard C.H.\} and Chan, \{Annie S.Y.\} and Wong, \{Jason W.H.\} and Cheng, \{Priscilla S.W.\} and Chan, \{Anthony K.W.\} and Jiangwen Zhang and Jue Shi and Xiaodan Fan and Kwong, \{Dora L.W.\} and Mak, \{Tak W.\} and Yuen, \{Siu Tsan\} and Hans Clevers and Leung, \{Suet Yi\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = dec,

day = "6",

doi = "10.1016/j.stem.2018.09.016",

language = "English",

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Yan, HHN, Siu, HC, Law, S, Ho, SL, Yue, SSK, Tsui, WY, Chan, D, Chan, AS, Ma, S, Lam, KO, Bartfeld, S, Man, AHY, Lee, BCH, Chan, ASY, Wong, JWH, Cheng, PSW, Chan, AKW, Zhang, J, Shi, J, Fan, X, Kwong, DLW, Mak, TW, Yuen, ST, Clevers, H & Leung, SY 2018, 'A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening', Cell stem cell, vol. 23, no. 6, pp. 882-897.e11. https://doi.org/10.1016/j.stem.2018.09.016

TY - JOUR

T1 - A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

AU - Yan, Helen H.N.

AU - Siu, Hoi Cheong

AU - Law, Simon

AU - Ho, Siu Lun

AU - Yue, Sarah S.K.

AU - Tsui, Wai Yin

AU - Chan, Dessy

AU - Chan, April S.

AU - Ma, Stephanie

AU - Lam, Ka On

AU - Bartfeld, Sina

AU - Man, Alice H.Y.

AU - Lee, Bernard C.H.

AU - Chan, Annie S.Y.

AU - Wong, Jason W.H.

AU - Cheng, Priscilla S.W.

AU - Chan, Anthony K.W.

AU - Zhang, Jiangwen

AU - Shi, Jue

AU - Fan, Xiaodan

AU - Kwong, Dora L.W.

AU - Mak, Tak W.

AU - Yuen, Siu Tsan

AU - Clevers, Hans

AU - Leung, Suet Yi

PY - 2018/12/6

Y1 - 2018/12/6

N2 - Leung and colleagues established a biobank of patient-derived gastric cancer organoids that encompasses a diverse array of subtypes and maintained long-term similarity to the original tumors. They used the organoids to perform large-scale drug screening that identified potential target drugs and could guide patient drug selection.

AB - Leung and colleagues established a biobank of patient-derived gastric cancer organoids that encompasses a diverse array of subtypes and maintained long-term similarity to the original tumors. They used the organoids to perform large-scale drug screening that identified potential target drugs and could guide patient drug selection.

KW - ARHGAP fusions

KW - EBV genome

KW - RHOA mutations

KW - biobank

KW - drug screening

KW - gastric cancer

KW - heterogeneity

KW - organoid culture

KW - transcriptome sequencing

KW - whole-exome sequencing

UR - https://www.scopus.com/pages/publications/85058484957

U2 - 10.1016/j.stem.2018.09.016

DO - 10.1016/j.stem.2018.09.016

M3 - Article

C2 - 30344100

AN - SCOPUS:85058484957

SN - 1934-5909

VL - 23

SP - 882-897.e11

JO - Cell stem cell

JF - Cell stem cell

IS - 6

ER -

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

Abstract

Keywords

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