A facelift for the general transcription factor TFIIA

Torill Høiby, Huiqing Zhou, Dimitra J. Mitsiou, Hendrik G. Stunnenberg

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


TFIIA was classified as a general transcription factor when it was first identified. Since then it has been debated to what extent it can actually be regarded as "general". The most notable feature of TFIIA is the proteolytical cleavage of the TFIIAαβ into a TFIIAα and TFIIAβ moiety which has long remained a mystery. Recent studies have showed that TFIIA is cleaved by Taspase1 which was initially identified as the protease for the proto-oncogene MLL. Cleavage of TFIIA does not appear to serve as a step required for its activation as the uncleaved TFIIA in the Taspase1 knock-outs adequately support bulk transcription. Instead, cleavage of TFIIA seems to affect its turn-over and may be a part of an intricate degradation mechanism that allows fine-tuning of cellular levels of TFIIA. Cleavage might also be responsible for switching transcription program as the uncleaved and cleaved TFIIA might have distinct promoter specificity during development and differentiation. This review will focus on functional characteristics of TFIIA and discuss novel insights in the role of this elusive transcription factor.

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalBBA - Gene Structure and Expression
Issue number7-8
Publication statusPublished - Jul 2007
Externally publishedYes


  • Cleavage
  • Taspase1
  • Transcription


Dive into the research topics of 'A facelift for the general transcription factor TFIIA'. Together they form a unique fingerprint.

Cite this