A novel local treatment strategy for advanced stage head and neck rhabdomyosarcomas in children: results of the AMORE protocol

J Buwalda, P F Schouwenburg, L E C M Blank, J H M Merks, M P Copper, S D Strackee, P A Voûte, H N Caron

Research output: Contribution to journalArticlepeer-review

Abstract

The AMORE protocol is a local treatment regimen for head and neck rhabdomyosarcomas (HNRMS), consisting of Ablative surgery, Moulage technique brachytherapy and surgical Reconstruction. The aim of AMORE is to intensify local treatment for children with HNRMS and to avoid external beam radiation therapy (EBRT) and its long-term sequelae. All children with primary irresectable, non-orbital HNRMS in whom EBRT was indicated, were evaluated for the feasibility of AMORE. In 20 children, AMORE was performed (15 with parameningeal disease and five with non-parameningeal disease). Complete remission was achieved in all 20 patients. Local complications were limited. 5 patients experienced a local relapse and 1 patient developed distant metastases. Estimated 5-year OS and EFS were 67.5 and 64.1% for the entire group, and 64.2 and 60.0% for the parameningeal subgroup. We conclude that the AMORE protocol is a feasible strategy, with a good local control rate. Long-term sequelae of EBRT might be avoided although, to date, the follow-up is too short for definitive conclusions regarding these sequelae.

Original languageEnglish
Pages (from-to)1594-602
Number of pages9
JournalEuropean journal of cancer (Oxford, England : 1990)
Volume39
Issue number11
DOIs
Publication statusPublished - Jul 2003
Externally publishedYes

Keywords

  • Antineoplastic Combined Chemotherapy Protocols/therapeutic use
  • Brachytherapy/methods
  • Child
  • Child, Preschool
  • Clinical Protocols
  • Combined Modality Therapy
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Head and Neck Neoplasms/drug therapy
  • Humans
  • Infant
  • Magnetic Resonance Imaging/methods
  • Male
  • Reconstructive Surgical Procedures
  • Rhabdomyosarcoma/drug therapy
  • Treatment Outcome

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