A physical map of 30,000 human genes

P. Deloukas, G. D. Schuler, G. Gyapay, E. M. Beasley, C. Soderlund, P. Rodriguez-Tomé, L. Hui, T. C. Matise, K. B. McKusick, J. S. Beckmann, S. Bentolila, M. T. Bihoreau, B. B. Birren, J. Browne, A. Butler, A. B. Castle, N. Chiannilkulchai, C. Clee, P. J.R. Day, A. DehejiaT. Dibling, N. Drouot, S. Duprat, C. Fizames, S. Fox, S. Gelling, L. Green, P. Harrison, R. Hocking, E. Holloway, S. Hunt, S. Keil, P. Lijnzaad, C. Louis-Dit-Sully, J. Ma, A. Mendis, J. Miller, J. Morissette, D. Muselet, H. C. Nusbaum, A. Peck, S. Rozen, D. Simon, D. K. Slonim, R. Staples, L. D. Stein, E. A. Stewart, M. A. Suchard, T. Thangarajah, N. Vega-Czarny, C. Webber, X. Wu, J. Hudson, C. Auffray, N. Nomura, J. M. Sikela, M. H. Polymeropoulos, M. R. James, E. S. Lander, T. J. Hudson, R. M. Myers, D. R. Cox, J. Weissenbach, M. S. Boguski, D. R. Bentley

Research output: Contribution to journalArticlepeer-review

595 Citations (Scopus)

Abstract

A map of 30,181 human gene-based markers was assembled and integrated with the current genetic map by radiation hybrid mapping. The gene map contains nearly twice as many genes as the previous release, includes most genes that encode proteins of known function, and is twofold to threefold more accurate than the previous version. A redesigned, more informative and functional World Wide Web site (www.ncbi.nlm.nih.gov/genemap) provides the mapping information and associated data and annotations. This resource constitutes an important infrastructure and tool for the study of complex genetic traits, the positional cloning of disease genes, the cross- referencing of mammalian genomes, and validated human transcribed sequences for large-scale studies of gene expression.

Original languageEnglish
Pages (from-to)744-746
Number of pages3
JournalScience
Volume282
Issue number5389
DOIs
Publication statusPublished - 23 Oct 1998
Externally publishedYes

Fingerprint

Dive into the research topics of 'A physical map of 30,000 human genes'. Together they form a unique fingerprint.

Cite this