A review of the clinical experience in pulsed dose rate brachytherapy

Brian V. Balgobind; Kees Koedooder; Diego Ordoñez Zúñiga; Raquel Dávila Fajardo; Coen R.N. Rasch; Bradley R. Pieters

doi:10.1259/bjr.20150310

A review of the clinical experience in pulsed dose rate brachytherapy

Brian V. Balgobind, Kees Koedooder, Diego Ordoñez Zúñiga, Raquel Dávila Fajardo, Coen R.N. Rasch, Bradley R. Pieters

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

Pulsed dose rate (PDR) brachytherapy is a treatment modality that combines physical advantages of high dose rate (HDR) brachytherapy with the radiobiological advantages of low dose rate brachytherapy. The aim of this review was to describe the effective clinical use of PDR brachytherapy worldwide in different tumour locations. We found 66 articles reporting on clinical PDR brachytherapy including the treatment procedure and outcome. Moreover, PDR brachytherapy has been applied in almost all tumour sites for which brachytherapy is indicated and with good local control and low toxicity. The main advantage of PDR is, because of the small pulse sizes used, the ability to spare normal tissue. In certain cases, HDR resembles PDR brachytherapy by the use of multifractionated low-fraction dose.

Original language	English
Journal	British Journal of Radiology
Volume	88
Issue number	1055
DOIs	https://doi.org/10.1259/bjr.20150310
Publication status	Published - 2015
Externally published	Yes

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abstract = "Pulsed dose rate (PDR) brachytherapy is a treatment modality that combines physical advantages of high dose rate (HDR) brachytherapy with the radiobiological advantages of low dose rate brachytherapy. The aim of this review was to describe the effective clinical use of PDR brachytherapy worldwide in different tumour locations. We found 66 articles reporting on clinical PDR brachytherapy including the treatment procedure and outcome. Moreover, PDR brachytherapy has been applied in almost all tumour sites for which brachytherapy is indicated and with good local control and low toxicity. The main advantage of PDR is, because of the small pulse sizes used, the ability to spare normal tissue. In certain cases, HDR resembles PDR brachytherapy by the use of multifractionated low-fraction dose.",

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AU - Balgobind, Brian V.

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AU - Zúñiga, Diego Ordoñez

AU - Fajardo, Raquel Dávila

AU - Rasch, Coen R.N.

AU - Pieters, Bradley R.

PY - 2015

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AB - Pulsed dose rate (PDR) brachytherapy is a treatment modality that combines physical advantages of high dose rate (HDR) brachytherapy with the radiobiological advantages of low dose rate brachytherapy. The aim of this review was to describe the effective clinical use of PDR brachytherapy worldwide in different tumour locations. We found 66 articles reporting on clinical PDR brachytherapy including the treatment procedure and outcome. Moreover, PDR brachytherapy has been applied in almost all tumour sites for which brachytherapy is indicated and with good local control and low toxicity. The main advantage of PDR is, because of the small pulse sizes used, the ability to spare normal tissue. In certain cases, HDR resembles PDR brachytherapy by the use of multifractionated low-fraction dose.

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A review of the clinical experience in pulsed dose rate brachytherapy

Abstract

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