A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review

Raquel Dávila Fajardo, Bradley R. Pieters, Jim C.H. Wilde, Hugo A. Heij, Rafal Chrzan, Godelieve Tytgat, Annelies M.C. Mavinkurve-Groothuis, Anne Smets, Petra S. Kroon, An Van Damme, Kees P. van de Ven, Ronald R. de Krijger, Marc R. Lilien, Marc H. Wijnen, Marry M. van den Heuvel-Eibrink, Geert O. Janssens

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

PURPOSE: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.

RESULTS (METHODS AND CASE DESCRIPTION): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function.

CONCLUSIONS: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.

Original languageEnglish
Pages (from-to)478-484
Number of pages7
JournalBrachytherapy
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Mar 2021

Keywords

  • Brachytherapy/methods
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Kidney Neoplasms/radiotherapy
  • Nephrectomy
  • Retrospective Studies
  • Wilms Tumor/radiotherapy

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