A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Philip Stephens; Sarah Edkins; Helen Davies; Chris Greenman; Charles Cox; Chris Hunter; Graham Bignell; Jon Teague; Raffaella Smith; Claire Stevens; Sarah O'Meara; Adrian Parker; Patrick Tarpey; Tim Avis; Andy Barthorpe; Lisa Brackenbury; Gemma Buck; Adam Butler; Jody Clements; Jennifer Cole; Ed Dicks; Ken Edwards; Simon Forbes; Matthew Gorton; Kristian Gray; Kelly Halliday; Rachel Harrison; Katy Hills; Jonathon Hinton; David Jones; Vivienne Kosmidou; Ross Laman; Richard Lugg; Andrew Menzies; Janet Perry; Robert Petty; Keiran Raine; Rebecca Shepherd; Alexandra Small; Helen Solomon; Yvonne Stephens; Calli Tofts; Jennifer Varian; Anthony Webb; Sofie West; Sara Widaa; Andrew Yates; Francis Brasseur; Colin S. Cooper; Adrienne M. Flanagan; Anthony Green; Maggie Knowles; Suet Y. Leung; Leendert H.J. Looijenga; Bruce Malkowicz; Marco A. Pierotti; Bin Teh; Siu T. Yuen; Andrew G. Nicholson; Sunil Lakhani; Douglas F. Easton; Barbara L. Weber; Michael R. Stratton; P. Andrew Futreal; Richard Wooster

doi:10.1038/ng1571

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Philip Stephens
, Sarah Edkins
, Helen Davies
, Chris Greenman
, Charles Cox
, Chris Hunter
, Graham Bignell
, Jon Teague
, Raffaella Smith
, Claire Stevens
, Sarah O'Meara
, Adrian Parker
, Patrick Tarpey
, Tim Avis
, Andy Barthorpe
, Lisa Brackenbury
, Gemma Buck
, Adam Butler
, Jody Clements
, Jennifer Cole

Ed Dicks, Ken Edwards, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne Stephens, Calli Tofts, Jennifer Varian, Anthony Webb, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S. Cooper, Adrienne M. Flanagan, Anthony Green, Maggie Knowles, Suet Y. Leung, Leendert H.J. Looijenga, Bruce Malkowicz, Marco A. Pierotti, Bin Teh, Siu T. Yuen, Andrew G. Nicholson, Sunil Lakhani, Douglas F. Easton, Barbara L. Weber, Michael R. Stratton, P. Andrew Futreal, Richard Wooster

Research output: Contribution to journal › Article › peer-review

294 Citations (Scopus)

Abstract

We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

Original language	English
Pages (from-to)	590-592
Number of pages	3
Journal	Nature Genetics
Volume	37
Issue number	6
DOIs	https://doi.org/10.1038/ng1571
Publication status	Published - Jun 2005
Externally published	Yes

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Stephens, P., Edkins, S., Davies, H., Greenman, C., Cox, C., Hunter, C., Bignell, G., Teague, J., Smith, R., Stevens, C., O'Meara, S., Parker, A., Tarpey, P., Avis, T., Barthorpe, A., Brackenbury, L., Buck, G., Butler, A., Clements, J., ... Wooster, R. (2005). A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nature Genetics, 37(6), 590-592. https://doi.org/10.1038/ng1571

@article{755407143f7a41c9b39757166f5be0fd,

title = "A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer",

abstract = "We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.",

author = "Philip Stephens and Sarah Edkins and Helen Davies and Chris Greenman and Charles Cox and Chris Hunter and Graham Bignell and Jon Teague and Raffaella Smith and Claire Stevens and Sarah O'Meara and Adrian Parker and Patrick Tarpey and Tim Avis and Andy Barthorpe and Lisa Brackenbury and Gemma Buck and Adam Butler and Jody Clements and Jennifer Cole and Ed Dicks and Ken Edwards and Simon Forbes and Matthew Gorton and Kristian Gray and Kelly Halliday and Rachel Harrison and Katy Hills and Jonathon Hinton and David Jones and Vivienne Kosmidou and Ross Laman and Richard Lugg and Andrew Menzies and Janet Perry and Robert Petty and Keiran Raine and Rebecca Shepherd and Alexandra Small and Helen Solomon and Yvonne Stephens and Calli Tofts and Jennifer Varian and Anthony Webb and Sofie West and Sara Widaa and Andrew Yates and Francis Brasseur and Cooper, \{Colin S.\} and Flanagan, \{Adrienne M.\} and Anthony Green and Maggie Knowles and Leung, \{Suet Y.\} and Looijenga, \{Leendert H.J.\} and Bruce Malkowicz and Pierotti, \{Marco A.\} and Bin Teh and Yuen, \{Siu T.\} and Nicholson, \{Andrew G.\} and Sunil Lakhani and Easton, \{Douglas F.\} and Weber, \{Barbara L.\} and Stratton, \{Michael R.\} and Futreal, \{P. Andrew\} and Richard Wooster",

year = "2005",

month = jun,

doi = "10.1038/ng1571",

language = "English",

volume = "37",

pages = "590--592",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "6",

}

Stephens, P, Edkins, S, Davies, H, Greenman, C, Cox, C, Hunter, C, Bignell, G, Teague, J, Smith, R, Stevens, C, O'Meara, S, Parker, A, Tarpey, P, Avis, T, Barthorpe, A, Brackenbury, L, Buck, G, Butler, A, Clements, J, Cole, J, Dicks, E, Edwards, K, Forbes, S, Gorton, M, Gray, K, Halliday, K, Harrison, R, Hills, K, Hinton, J, Jones, D, Kosmidou, V, Laman, R, Lugg, R, Menzies, A, Perry, J, Petty, R, Raine, K, Shepherd, R, Small, A, Solomon, H, Stephens, Y, Tofts, C, Varian, J, Webb, A, West, S, Widaa, S, Yates, A, Brasseur, F, Cooper, CS, Flanagan, AM, Green, A, Knowles, M, Leung, SY, Looijenga, LHJ, Malkowicz, B, Pierotti, MA, Teh, B, Yuen, ST, Nicholson, AG, Lakhani, S, Easton, DF, Weber, BL, Stratton, MR, Futreal, PA & Wooster, R 2005, 'A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer', Nature Genetics, vol. 37, no. 6, pp. 590-592. https://doi.org/10.1038/ng1571

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AU - Bignell, Graham

AU - Teague, Jon

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AU - Parker, Adrian

AU - Tarpey, Patrick

AU - Avis, Tim

AU - Barthorpe, Andy

AU - Brackenbury, Lisa

AU - Buck, Gemma

AU - Butler, Adam

AU - Clements, Jody

AU - Cole, Jennifer

AU - Dicks, Ed

AU - Edwards, Ken

AU - Forbes, Simon

AU - Gorton, Matthew

AU - Gray, Kristian

AU - Halliday, Kelly

AU - Harrison, Rachel

AU - Hills, Katy

AU - Hinton, Jonathon

AU - Jones, David

AU - Kosmidou, Vivienne

AU - Laman, Ross

AU - Lugg, Richard

AU - Menzies, Andrew

AU - Perry, Janet

AU - Petty, Robert

AU - Raine, Keiran

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AU - Small, Alexandra

AU - Solomon, Helen

AU - Stephens, Yvonne

AU - Tofts, Calli

AU - Varian, Jennifer

AU - Webb, Anthony

AU - West, Sofie

AU - Widaa, Sara

AU - Yates, Andrew

AU - Brasseur, Francis

AU - Cooper, Colin S.

AU - Flanagan, Adrienne M.

AU - Green, Anthony

AU - Knowles, Maggie

AU - Leung, Suet Y.

AU - Looijenga, Leendert H.J.

AU - Malkowicz, Bruce

AU - Pierotti, Marco A.

AU - Teh, Bin

AU - Yuen, Siu T.

AU - Nicholson, Andrew G.

AU - Lakhani, Sunil

AU - Easton, Douglas F.

AU - Weber, Barbara L.

AU - Stratton, Michael R.

AU - Futreal, P. Andrew

AU - Wooster, Richard

PY - 2005/6

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N2 - We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

AB - We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

UR - https://www.scopus.com/pages/publications/20044381123

U2 - 10.1038/ng1571

DO - 10.1038/ng1571

M3 - Article

C2 - 15908952

AN - SCOPUS:20044381123

SN - 1061-4036

VL - 37

SP - 590

EP - 592

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

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