A twice daily posaconazole dosing algorithm for children with chronic granulomatous disease

Marieke E.B. Welzen, Roger J.M. Brüggemann, J. Merlijn Van Den Berg, Heleen W. Voogt, Jos H. Gilissen, Dasja Pajkrt, Nigel Klein, David M. Burger, Adilia Warris

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Posaconazole (PSZ) may be an attractive alternative for antifungal prophylaxis in children with chronic granulomatous disease. Experience with PSZ in pediatric patients is limited, and no specific dose recommendations exist. A twice daily dosing algorithm based on allometric scaling (body-weight based) for PSZ results in adequate exposure and appears to be safe in children with chronic granulomatous disease.

Original languageEnglish
Pages (from-to)794-797
Number of pages4
JournalPediatric Infectious Disease Journal
Volume30
Issue number9
DOIs
Publication statusPublished - Sept 2011
Externally publishedYes

Keywords

  • CGD
  • children
  • pharmacokinetics
  • posaconazole
  • prophylaxis

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