Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma

Cyrano Chatziantoniou; Roelof van Ewijk; Madeleine Adams; Patrizia Bertolini; Gianni Bisogno; Amine Bouhamama; Pablo Caro-Dominguez; Valérie Charon; Ana Coma; Rana Dandis; Christine Devalck; Giulia De Donno; Andrea Ferrari; Marta Fiocco; Soledad Gallego; Chiara Giraudo; Heidi Glosli; Simone A.J. ter Horst; Meriel Jenney; Willemijn M. Klein; Alexander Leemans; Julie Leseur; Henry C. Mandeville; Kieran McHugh; Johannes H.M. Merks; Veronique Minard-Colin; Salma Moalla; Carlo Morosi; Daniel Orbach; Lil Sofie Ording Müller; Erika Pace; Pier Luigi Di Paolo; Katia Perruccio; Lucia Quaglietta; Marleen Renard; Rick R. van Rijn; Antonio Ruggiero; Sara I. Sirvent; Reineke A. Schoot; Alberto De Luca

doi:10.1007/s00247-025-06263-w

Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma

Cyrano Chatziantoniou
, Roelof van Ewijk
, Madeleine Adams
, Patrizia Bertolini
, Gianni Bisogno
, Amine Bouhamama
, Pablo Caro-Dominguez
, Valérie Charon
, Ana Coma
, Rana Dandis
, Christine Devalck
, Giulia De Donno
, Andrea Ferrari
, Marta Fiocco
, Soledad Gallego
, Chiara Giraudo
, Heidi Glosli
, Simone A.J. ter Horst
, Meriel Jenney
, Willemijn M. Klein

Alexander Leemans, Julie Leseur, Henry C. Mandeville, Kieran McHugh, Johannes H.M. Merks, Veronique Minard-Colin, Salma Moalla, Carlo Morosi, Daniel Orbach, Lil Sofie Ording Müller, Erika Pace, Pier Luigi Di Paolo, Katia Perruccio, Lucia Quaglietta, Marleen Renard, Rick R. van Rijn, Antonio Ruggiero, Sara I. Sirvent, Reineke A. Schoot, Alberto De Luca

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

BACKGROUND: The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is a potential biomarker for treatment response in pediatric rhabdomyosarcoma. Due to its rarity, investigations into this marker require multicenter approaches, which can result in variability in acquisition parameters.

OBJECTIVE: To evaluate the impact of different acquisition parameters on ADC estimates in a multicenter dataset of rhabdomyosarcoma patients.

MATERIALS AND METHODS: We included 114 pediatric and adolescent rhabdomyosarcoma patients from 22 treatment centers (195 scans). Median age: 6.0 years (0.3-21.8). We evaluated the impact of voxel size, (number of) b-values, and echo time on tumor ADC values. The effect of the highest b-value was separately investigated on a subset of scans with five or more b-values.

RESULTS: We observed a large variability in key acquisition parameters in the overall cohort, and for individual imaging centers. No parameter showed a significant effect on ADC estimates of the whole cohort when corrected for multiple-comparisons. Decreasing the highest b-value within the same acquisition caused ADC to decrease on average by 2.8% per 100 s mm -2. Differing b-values between scans at diagnosis and treatment response yielded significant changes in the longitudinal ADC for each patient (P<0.05).

CONCLUSION: While we observed wide variation of acquisition parameters within a multicenter cohort, this did not lead to significant cross-sectional differences of tumor ADC. However, we found that modifying the highest b-value between baseline and follow-up can impact longitudinal ADC estimates. As such, we recommend the highest b-value to remain constant. This retrospective study was reviewed and approved by the Internal Review Board (UMC Utrecht, reference ID: 18-412).

Original language	English
Pages (from-to)	1598-1610
Number of pages	13
Journal	Pediatric Radiology
Volume	55
Issue number	8
DOIs	https://doi.org/10.1007/s00247-025-06263-w
Publication status	Published - Jul 2025

Keywords

Adolescent
Child
Diffusion magnetic resonance imaging
Rhabdomyosarcoma
Humans
Child, Preschool
Infant
Male
Rhabdomyosarcoma/diagnostic imaging
Young Adult
Female
Diffusion Magnetic Resonance Imaging/methods
Image Interpretation, Computer-Assisted/methods
Retrospective Studies

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10.1007/s00247-025-06263-w

Cite this

Chatziantoniou, C., van Ewijk, R., Adams, M., Bertolini, P., Bisogno, G., Bouhamama, A., Caro-Dominguez, P., Charon, V., Coma, A., Dandis, R., Devalck, C., De Donno, G., Ferrari, A., Fiocco, M., Gallego, S., Giraudo, C., Glosli, H., ter Horst, S. A. J., Jenney, M., ... De Luca, A. (2025). Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma. Pediatric Radiology, 55(8), 1598-1610. https://doi.org/10.1007/s00247-025-06263-w

@article{6e25883b6cdd4e9b913565d750ba304f,

title = "Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma",

abstract = "BACKGROUND: The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is a potential biomarker for treatment response in pediatric rhabdomyosarcoma. Due to its rarity, investigations into this marker require multicenter approaches, which can result in variability in acquisition parameters.OBJECTIVE: To evaluate the impact of different acquisition parameters on ADC estimates in a multicenter dataset of rhabdomyosarcoma patients.MATERIALS AND METHODS: We included 114 pediatric and adolescent rhabdomyosarcoma patients from 22 treatment centers (195 scans). Median age: 6.0 years (0.3-21.8). We evaluated the impact of voxel size, (number of) b-values, and echo time on tumor ADC values. The effect of the highest b-value was separately investigated on a subset of scans with five or more b-values.RESULTS: We observed a large variability in key acquisition parameters in the overall cohort, and for individual imaging centers. No parameter showed a significant effect on ADC estimates of the whole cohort when corrected for multiple-comparisons. Decreasing the highest b-value within the same acquisition caused ADC to decrease on average by 2.8\% per 100 s mm -2. Differing b-values between scans at diagnosis and treatment response yielded significant changes in the longitudinal ADC for each patient (P<0.05). CONCLUSION: While we observed wide variation of acquisition parameters within a multicenter cohort, this did not lead to significant cross-sectional differences of tumor ADC. However, we found that modifying the highest b-value between baseline and follow-up can impact longitudinal ADC estimates. As such, we recommend the highest b-value to remain constant. This retrospective study was reviewed and approved by the Internal Review Board (UMC Utrecht, reference ID: 18-412).",

keywords = "Adolescent, Child, Diffusion magnetic resonance imaging, Rhabdomyosarcoma, Humans, Child, Preschool, Infant, Male, Rhabdomyosarcoma/diagnostic imaging, Young Adult, Female, Diffusion Magnetic Resonance Imaging/methods, Image Interpretation, Computer-Assisted/methods, Retrospective Studies",

author = "Cyrano Chatziantoniou and \{van Ewijk\}, Roelof and Madeleine Adams and Patrizia Bertolini and Gianni Bisogno and Amine Bouhamama and Pablo Caro-Dominguez and Val{\'e}rie Charon and Ana Coma and Rana Dandis and Christine Devalck and \{De Donno\}, Giulia and Andrea Ferrari and Marta Fiocco and Soledad Gallego and Chiara Giraudo and Heidi Glosli and \{ter Horst\}, \{Simone A.J.\} and Meriel Jenney and Klein, \{Willemijn M.\} and Alexander Leemans and Julie Leseur and Mandeville, \{Henry C.\} and Kieran McHugh and Merks, \{Johannes H.M.\} and Veronique Minard-Colin and Salma Moalla and Carlo Morosi and Daniel Orbach and \{Ording M{\"u}ller\}, \{Lil Sofie\} and Erika Pace and \{Di Paolo\}, \{Pier Luigi\} and Katia Perruccio and Lucia Quaglietta and Marleen Renard and \{van Rijn\}, \{Rick R.\} and Antonio Ruggiero and Sirvent, \{Sara I.\} and Schoot, \{Reineke A.\} and \{De Luca\}, Alberto",

note = "{\textcopyright} 2025. The Author(s).",

year = "2025",

month = jul,

doi = "10.1007/s00247-025-06263-w",

language = "English",

volume = "55",

pages = "1598--1610",

journal = "Pediatric Radiology",

issn = "0301-0449",

publisher = "Springer Nature",

number = "8",

}

Chatziantoniou, C, van Ewijk, R, Adams, M, Bertolini, P, Bisogno, G, Bouhamama, A, Caro-Dominguez, P, Charon, V, Coma, A, Dandis, R, Devalck, C, De Donno, G, Ferrari, A, Fiocco, M, Gallego, S, Giraudo, C, Glosli, H, ter Horst, SAJ, Jenney, M, Klein, WM, Leemans, A, Leseur, J, Mandeville, HC, McHugh, K, Merks, JHM, Minard-Colin, V, Moalla, S, Morosi, C, Orbach, D, Ording Müller, LS, Pace, E, Di Paolo, PL, Perruccio, K, Quaglietta, L, Renard, M, van Rijn, RR, Ruggiero, A, Sirvent, SI, Schoot, RA & De Luca, A 2025, 'Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma', Pediatric Radiology, vol. 55, no. 8, pp. 1598-1610. https://doi.org/10.1007/s00247-025-06263-w

TY - JOUR

T1 - Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma

AU - Chatziantoniou, Cyrano

AU - van Ewijk, Roelof

AU - Adams, Madeleine

AU - Bertolini, Patrizia

AU - Bisogno, Gianni

AU - Bouhamama, Amine

AU - Caro-Dominguez, Pablo

AU - Charon, Valérie

AU - Coma, Ana

AU - Dandis, Rana

AU - Devalck, Christine

AU - De Donno, Giulia

AU - Ferrari, Andrea

AU - Fiocco, Marta

AU - Gallego, Soledad

AU - Giraudo, Chiara

AU - Glosli, Heidi

AU - ter Horst, Simone A.J.

AU - Jenney, Meriel

AU - Klein, Willemijn M.

AU - Leemans, Alexander

AU - Leseur, Julie

AU - Mandeville, Henry C.

AU - McHugh, Kieran

AU - Merks, Johannes H.M.

AU - Minard-Colin, Veronique

AU - Moalla, Salma

AU - Morosi, Carlo

AU - Orbach, Daniel

AU - Ording Müller, Lil Sofie

AU - Pace, Erika

AU - Di Paolo, Pier Luigi

AU - Perruccio, Katia

AU - Quaglietta, Lucia

AU - Renard, Marleen

AU - van Rijn, Rick R.

AU - Ruggiero, Antonio

AU - Sirvent, Sara I.

AU - Schoot, Reineke A.

AU - De Luca, Alberto

PY - 2025/7

Y1 - 2025/7

N2 - BACKGROUND: The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is a potential biomarker for treatment response in pediatric rhabdomyosarcoma. Due to its rarity, investigations into this marker require multicenter approaches, which can result in variability in acquisition parameters.OBJECTIVE: To evaluate the impact of different acquisition parameters on ADC estimates in a multicenter dataset of rhabdomyosarcoma patients.MATERIALS AND METHODS: We included 114 pediatric and adolescent rhabdomyosarcoma patients from 22 treatment centers (195 scans). Median age: 6.0 years (0.3-21.8). We evaluated the impact of voxel size, (number of) b-values, and echo time on tumor ADC values. The effect of the highest b-value was separately investigated on a subset of scans with five or more b-values.RESULTS: We observed a large variability in key acquisition parameters in the overall cohort, and for individual imaging centers. No parameter showed a significant effect on ADC estimates of the whole cohort when corrected for multiple-comparisons. Decreasing the highest b-value within the same acquisition caused ADC to decrease on average by 2.8% per 100 s mm -2. Differing b-values between scans at diagnosis and treatment response yielded significant changes in the longitudinal ADC for each patient (P<0.05). CONCLUSION: While we observed wide variation of acquisition parameters within a multicenter cohort, this did not lead to significant cross-sectional differences of tumor ADC. However, we found that modifying the highest b-value between baseline and follow-up can impact longitudinal ADC estimates. As such, we recommend the highest b-value to remain constant. This retrospective study was reviewed and approved by the Internal Review Board (UMC Utrecht, reference ID: 18-412).

AB - BACKGROUND: The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) is a potential biomarker for treatment response in pediatric rhabdomyosarcoma. Due to its rarity, investigations into this marker require multicenter approaches, which can result in variability in acquisition parameters.OBJECTIVE: To evaluate the impact of different acquisition parameters on ADC estimates in a multicenter dataset of rhabdomyosarcoma patients.MATERIALS AND METHODS: We included 114 pediatric and adolescent rhabdomyosarcoma patients from 22 treatment centers (195 scans). Median age: 6.0 years (0.3-21.8). We evaluated the impact of voxel size, (number of) b-values, and echo time on tumor ADC values. The effect of the highest b-value was separately investigated on a subset of scans with five or more b-values.RESULTS: We observed a large variability in key acquisition parameters in the overall cohort, and for individual imaging centers. No parameter showed a significant effect on ADC estimates of the whole cohort when corrected for multiple-comparisons. Decreasing the highest b-value within the same acquisition caused ADC to decrease on average by 2.8% per 100 s mm -2. Differing b-values between scans at diagnosis and treatment response yielded significant changes in the longitudinal ADC for each patient (P<0.05). CONCLUSION: While we observed wide variation of acquisition parameters within a multicenter cohort, this did not lead to significant cross-sectional differences of tumor ADC. However, we found that modifying the highest b-value between baseline and follow-up can impact longitudinal ADC estimates. As such, we recommend the highest b-value to remain constant. This retrospective study was reviewed and approved by the Internal Review Board (UMC Utrecht, reference ID: 18-412).

KW - Adolescent

KW - Child

KW - Diffusion magnetic resonance imaging

KW - Rhabdomyosarcoma

KW - Humans

KW - Child, Preschool

KW - Infant

KW - Male

KW - Rhabdomyosarcoma/diagnostic imaging

KW - Young Adult

KW - Female

KW - Diffusion Magnetic Resonance Imaging/methods

KW - Image Interpretation, Computer-Assisted/methods

KW - Retrospective Studies

UR - https://www.scopus.com/pages/publications/105011823656

UR - https://www.mendeley.com/catalogue/a570994b-08be-3fcc-9a8b-7171235a5dea/

U2 - 10.1007/s00247-025-06263-w

DO - 10.1007/s00247-025-06263-w

M3 - Article

C2 - 40493048

AN - SCOPUS:105011823656

SN - 0301-0449

VL - 55

SP - 1598

EP - 1610

JO - Pediatric Radiology

JF - Pediatric Radiology

IS - 8

ER -

Acquisition matters - how do scan parameters affect apparent diffusion coefficient estimates in pediatric rhabdomyosarcoma

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Keywords

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