Advances in molecular markers of germ cell cancer in patients with disorders of sex development

Yvonne G van der Zwan; Martine Cools; Leendert H J Looijenga

doi:10.1159/000363641

Advances in molecular markers of germ cell cancer in patients with disorders of sex development

Yvonne G van der Zwan
, Martine Cools
, Leendert H J Looijenga

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

The risk of malignant transformation of germ cells, leading to germ cell cancer (GCC) in patients with disorders of sex development, is highly heterogeneous and dependent on a number of parameters, of which the presence of Y-chromosomal material is essential. This chapter describes the networks, both protein-coding and regulatory processes, related to normal gonadal development and GCC, with focus on recent advances of molecular markers for early diagnosis.

Original language	English
Pages (from-to)	172-84
Number of pages	13
Journal	Endocrine development
Volume	27
DOIs	https://doi.org/10.1159/000363641
Publication status	Published - 2014
Externally published	Yes

Keywords

Biomarkers, Tumor/genetics
Disorders of Sex Development/complications
Humans
Neoplasms, Germ Cell and Embryonal/complications
Sex Determination Processes/physiology

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10.1159/000363641

Cite this

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title = "Advances in molecular markers of germ cell cancer in patients with disorders of sex development",

abstract = "The risk of malignant transformation of germ cells, leading to germ cell cancer (GCC) in patients with disorders of sex development, is highly heterogeneous and dependent on a number of parameters, of which the presence of Y-chromosomal material is essential. This chapter describes the networks, both protein-coding and regulatory processes, related to normal gonadal development and GCC, with focus on recent advances of molecular markers for early diagnosis.",

keywords = "Biomarkers, Tumor/genetics, Disorders of Sex Development/complications, Humans, Neoplasms, Germ Cell and Embryonal/complications, Sex Determination Processes/physiology",

author = "\{van der Zwan\}, \{Yvonne G\} and Martine Cools and Looijenga, \{Leendert H J\}",

note = "{\textcopyright} 2014 S. Karger AG, Basel.",

year = "2014",

doi = "10.1159/000363641",

language = "English",

volume = "27",

pages = "172--84",

journal = "Endocrine development",

issn = "1421-7082",

publisher = "S. Karger AG",

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AU - van der Zwan, Yvonne G

AU - Cools, Martine

AU - Looijenga, Leendert H J

PY - 2014

Y1 - 2014

N2 - The risk of malignant transformation of germ cells, leading to germ cell cancer (GCC) in patients with disorders of sex development, is highly heterogeneous and dependent on a number of parameters, of which the presence of Y-chromosomal material is essential. This chapter describes the networks, both protein-coding and regulatory processes, related to normal gonadal development and GCC, with focus on recent advances of molecular markers for early diagnosis.

AB - The risk of malignant transformation of germ cells, leading to germ cell cancer (GCC) in patients with disorders of sex development, is highly heterogeneous and dependent on a number of parameters, of which the presence of Y-chromosomal material is essential. This chapter describes the networks, both protein-coding and regulatory processes, related to normal gonadal development and GCC, with focus on recent advances of molecular markers for early diagnosis.

KW - Biomarkers, Tumor/genetics

KW - Disorders of Sex Development/complications

KW - Humans

KW - Neoplasms, Germ Cell and Embryonal/complications

KW - Sex Determination Processes/physiology

U2 - 10.1159/000363641

DO - 10.1159/000363641

M3 - Review article

C2 - 25247654

SN - 1421-7082

VL - 27

SP - 172

EP - 184

JO - Endocrine development

JF - Endocrine development

ER -

Advances in molecular markers of germ cell cancer in patients with disorders of sex development

Abstract

Keywords

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