Age-related cognitive decline: can neural stem cells help us?

Benedetta Artegiani, Federico Calegari

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)


Several studies suggest that an increase in adult neurogenesis has beneficial effects on emotional behavior and cognitive performance including learning and memory. The observation that aging has a negative effect on the proliferation of neural stem cells has prompted several laboratories to investigate new systems to artificially increase neurogenesis in senescent animals as a means to compensate for age-related cognitive decline. In this review we will discuss the systemic, cellular, and molecular changes induced by aging and affecting the neurogenic niche at the level of neural stem cell proliferation, their fate change, neuronal survival, and subsequent integration in the neuronal circuitry. Particular attention will be given to those manipulations that increase neurogenesis in the aged brain as a potential avenue towards therapy.

Original languageEnglish
Pages (from-to)176-86
Number of pages11
Issue number3
Publication statusPublished - Mar 2012
Externally publishedYes


  • Aging/pathology
  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Cognition
  • Cognition Disorders/etiology
  • Humans
  • Neural Stem Cells/transplantation
  • Neurogenesis
  • Neurons/pathology


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