Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery

I. J.M. Han-Geurts, A. N. van Geel, L. van Doorn, den Bakker M. den Bakker, A. M.M. Eggermont, C. Verhoef

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67 Citations (Scopus)


Aims: Aggressive angiomyxoma is a soft-tissue tumour of the pelvi-perineum. The recurrence rate is high, and often extensive resections are performed with considerable morbidity. In search of alternative treatment methods we present our experience in seven patients. Methods: The medical charts of seven patients treated in the last 20 years were reviewed. Follow-up data were obtained. In addition, a literature review from 1994 to 2004 regarding treatment and clinical outcome was performed. Results: All patients were female, and three were pregnant at the time of diagnosis. All patients underwent primary surgical treatment. In five patients the surgical margins were involved; one patient received adjuvant radiotherapy treatment. Three patients experienced a total of four recurrences after 2-10 years. These patients were treated with selective embolisation or surgery. At present all patients are disease-free, with follow-up ranging from 2 to 20 years after last treatment. Conclusion: Radical surgery does not seem to lead to a significant lower recurrence rate of aggressive angiomyxoma when compared to incomplete resection (R1), with or without radiotherapy or arterial embolisation. This casts doubt on the necessity of extensive surgery, especially in cases where an extensive surgical procedure will lead to great morbidity.

Original languageEnglish
Pages (from-to)1217-1221
Number of pages5
JournalEuropean Journal of Surgical Oncology
Issue number10
Publication statusPublished - Dec 2006
Externally publishedYes


  • Aggressive angiomyxoma
  • Embolisation
  • Radiotherapy
  • Surgery


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