An analysis of histology and DNA-ploidy in primary wilms tumors and their metastases and a study of the morphological effects of therapy

E. H. van Leeuwen; A. Postma; J. W. Oosterhuis; A. Meiring; C. J. Cornelisse; J. Koudstaal; W. M. Molenaar

doi:10.1007/BF00781683

An analysis of histology and DNA-ploidy in primary wilms tumors and their metastases and a study of the morphological effects of therapy

E. H. van Leeuwen, A. Postma, J. W. Oosterhuis, A. Meiring, C. J. Cornelisse, J. Koudstaal, W. M. Molenaar

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

In children with Wilms' tumours the length of survival is greatly influenced by success in preventing or controlling metastatic disease. The current study focuses on the morphological aspects of metastases when compared with the primary tumour. In 8 patients it appeared that blastema is the most likely component to metastasize, whereas epithelial and stromal components were hardly, if at all, represented in metastases. Furthermore, flow cytometric DNA ploidy determinations on 4 cases showed that both the primary tumours and the metastases had stemlines in the diploid and low aneuploid (hyperdiploid) range. Finally, in four cases the influence of therapy on morphology of the primary tumours was analyzed. In these cases blastema seemed to be the component most sensitive to therapy. Thus, blastema seems to play a central role in prognosis of Wilms' tumours; either reacting to therapy or, if insensitive, by metastasizing.

Original language	English
Pages (from-to)	487-494
Number of pages	8
Journal	Virchows Archiv A Pathological Anatomy and Histopathology
Volume	410
Issue number	6
DOIs	https://doi.org/10.1007/BF00781683
Publication status	Published - Nov 1987
Externally published	Yes

Keywords

Blastema
Chemotherapy
DNA-flowcytometry
Metastasis
Wilm's tumor

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10.1007/BF00781683

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van Leeuwen, E. H., Postma, A., Oosterhuis, J. W., Meiring, A., Cornelisse, C. J., Koudstaal, J., & Molenaar, W. M. (1987). An analysis of histology and DNA-ploidy in primary wilms tumors and their metastases and a study of the morphological effects of therapy. Virchows Archiv A Pathological Anatomy and Histopathology, 410(6), 487-494. https://doi.org/10.1007/BF00781683

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title = "An analysis of histology and DNA-ploidy in primary wilms tumors and their metastases and a study of the morphological effects of therapy",

abstract = "In children with Wilms' tumours the length of survival is greatly influenced by success in preventing or controlling metastatic disease. The current study focuses on the morphological aspects of metastases when compared with the primary tumour. In 8 patients it appeared that blastema is the most likely component to metastasize, whereas epithelial and stromal components were hardly, if at all, represented in metastases. Furthermore, flow cytometric DNA ploidy determinations on 4 cases showed that both the primary tumours and the metastases had stemlines in the diploid and low aneuploid (hyperdiploid) range. Finally, in four cases the influence of therapy on morphology of the primary tumours was analyzed. In these cases blastema seemed to be the component most sensitive to therapy. Thus, blastema seems to play a central role in prognosis of Wilms' tumours; either reacting to therapy or, if insensitive, by metastasizing.",

keywords = "Blastema, Chemotherapy, DNA-flowcytometry, Metastasis, Wilm's tumor",

author = "{van Leeuwen}, {E. H.} and A. Postma and Oosterhuis, {J. W.} and A. Meiring and Cornelisse, {C. J.} and J. Koudstaal and Molenaar, {W. M.}",

year = "1987",

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AU - van Leeuwen, E. H.

AU - Postma, A.

AU - Oosterhuis, J. W.

AU - Meiring, A.

AU - Cornelisse, C. J.

AU - Koudstaal, J.

AU - Molenaar, W. M.

PY - 1987/11

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N2 - In children with Wilms' tumours the length of survival is greatly influenced by success in preventing or controlling metastatic disease. The current study focuses on the morphological aspects of metastases when compared with the primary tumour. In 8 patients it appeared that blastema is the most likely component to metastasize, whereas epithelial and stromal components were hardly, if at all, represented in metastases. Furthermore, flow cytometric DNA ploidy determinations on 4 cases showed that both the primary tumours and the metastases had stemlines in the diploid and low aneuploid (hyperdiploid) range. Finally, in four cases the influence of therapy on morphology of the primary tumours was analyzed. In these cases blastema seemed to be the component most sensitive to therapy. Thus, blastema seems to play a central role in prognosis of Wilms' tumours; either reacting to therapy or, if insensitive, by metastasizing.

AB - In children with Wilms' tumours the length of survival is greatly influenced by success in preventing or controlling metastatic disease. The current study focuses on the morphological aspects of metastases when compared with the primary tumour. In 8 patients it appeared that blastema is the most likely component to metastasize, whereas epithelial and stromal components were hardly, if at all, represented in metastases. Furthermore, flow cytometric DNA ploidy determinations on 4 cases showed that both the primary tumours and the metastases had stemlines in the diploid and low aneuploid (hyperdiploid) range. Finally, in four cases the influence of therapy on morphology of the primary tumours was analyzed. In these cases blastema seemed to be the component most sensitive to therapy. Thus, blastema seems to play a central role in prognosis of Wilms' tumours; either reacting to therapy or, if insensitive, by metastasizing.

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KW - Chemotherapy

KW - DNA-flowcytometry

KW - Metastasis

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VL - 410

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JF - Virchows Archiv A Pathological Anatomy and Histopathology

IS - 6

ER -

An analysis of histology and DNA-ploidy in primary wilms tumors and their metastases and a study of the morphological effects of therapy

Abstract

Keywords

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