TY - JOUR
T1 - An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
AU - Roepman, Paul
AU - Wessels, Lodewyk F.A.
AU - Kettelarij, Nienke
AU - Kemmeren, Patrick
AU - Miles, Antony J.
AU - Lijnzaad, Philip
AU - Tilanus, Marcel G.J.
AU - Koole, Ronald
AU - Hordijk, Gert Jan
AU - Van Der Vliet, Peter C.
AU - Reinders, Marcel J.T.
AU - Slootweg, Piet J.
AU - Holstege, Frank C.P.
N1 - Funding Information:
We thank D. van Leenen, M. Groot-Koerkamp and J. van Helvoort for microarray production and technology optimization; M. Verdaasdonk for assistance with biopsies; A. Leijen for computer assistance and J. van de Peppel for advice and discussion. Work in the group of F.C.P.H. is supported by grants from the Netherlands Organization for Scientific Research and by the European Union fifth framework project TEMBLOR.
PY - 2005/2
Y1 - 2005/2
N2 - Metastasis is the process by which cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some types of cancer, early detection of metastasis at lymph nodes close to the site of the primary tumor is pivotal for appropriate treatment. Because it can be difficult to detect lymph node metastases reliably, many individuals currently receive inappropriate treatment. We show here that DNA microarray gene-expression profiling can detect lymph node metastases for primary head and neck squamous cell carcinomas that arise in the oral cavity and oropharynx. The predictor, established with an 82-tumor training set, outperforms current clinical diagnosis when independently validated. The 102 predictor genes offer unique insights into the processes underlying metastasis. The results show that the metastatic state can be deciphered from the primary tumor gene-expression pattern and that treatment can be substantially improved.
AB - Metastasis is the process by which cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some types of cancer, early detection of metastasis at lymph nodes close to the site of the primary tumor is pivotal for appropriate treatment. Because it can be difficult to detect lymph node metastases reliably, many individuals currently receive inappropriate treatment. We show here that DNA microarray gene-expression profiling can detect lymph node metastases for primary head and neck squamous cell carcinomas that arise in the oral cavity and oropharynx. The predictor, established with an 82-tumor training set, outperforms current clinical diagnosis when independently validated. The 102 predictor genes offer unique insights into the processes underlying metastasis. The results show that the metastatic state can be deciphered from the primary tumor gene-expression pattern and that treatment can be substantially improved.
UR - https://www.scopus.com/pages/publications/13444269762
U2 - 10.1038/ng1502
DO - 10.1038/ng1502
M3 - Article
C2 - 15640797
AN - SCOPUS:13444269762
SN - 1061-4036
VL - 37
SP - 182
EP - 186
JO - Nature Genetics
JF - Nature Genetics
IS - 2
ER -