TY - JOUR
T1 - An integral program for tissue renewal and regeneration
T2 - Wnt signaling and stem cell control
AU - Clevers, Hans
AU - Loh, Kyle M.
AU - Nusse, Roel
N1 - Publisher Copyright:
© 2014 by the American Association for the Advancement of Science; all rights reserved.
PY - 2014/10/3
Y1 - 2014/10/3
N2 - Stem cells fuel tissue development, renewal, and regeneration, and these activities are controlled by the local stem cell microenvironment, the "niche." Wnt signals emanating from the niche can act as self-renewal factors for stem cells in multiple mammalian tissues. Wnt proteins are lipid-modified, which constrains them to act as short-range cellular signals. The locality of Wnt signaling dictates that stem cells exiting the Wnt signaling domain differentiate, spatially delimiting the niche in certain tissues. In some instances, stem cells may act as or generate their own niche, enabling the self-organization of patterned tissues. In this Review, we discuss the various ways by which Wnt operates in stem cell control, in doing so, identify an integral program for tissue renewal and regeneration.
AB - Stem cells fuel tissue development, renewal, and regeneration, and these activities are controlled by the local stem cell microenvironment, the "niche." Wnt signals emanating from the niche can act as self-renewal factors for stem cells in multiple mammalian tissues. Wnt proteins are lipid-modified, which constrains them to act as short-range cellular signals. The locality of Wnt signaling dictates that stem cells exiting the Wnt signaling domain differentiate, spatially delimiting the niche in certain tissues. In some instances, stem cells may act as or generate their own niche, enabling the self-organization of patterned tissues. In this Review, we discuss the various ways by which Wnt operates in stem cell control, in doing so, identify an integral program for tissue renewal and regeneration.
UR - http://www.scopus.com/inward/record.url?scp=84907487414&partnerID=8YFLogxK
U2 - 10.1126/science.1248012
DO - 10.1126/science.1248012
M3 - Review article
C2 - 25278615
AN - SCOPUS:84907487414
SN - 0036-8075
VL - 346
JO - Science
JF - Science
IS - 6205
M1 - 1248012
ER -