An Overview of Liver Directed Locoregional Therapies

Diederik J. Höppener; Dirk J. Grünhagen; Alexander M.M. Eggermont; Astrid A.M. van der Veldt; Cornelis Verhoef

doi:10.1016/j.soc.2020.09.001

An Overview of Liver Directed Locoregional Therapies

Diederik J. Höppener, Dirk J. Grünhagen, Alexander M.M. Eggermont, Astrid A.M. van der Veldt, Cornelis Verhoef

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Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.

Original language	English
Pages (from-to)	103-123
Number of pages	21
Journal	Surgical Oncology Clinics of North America
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.soc.2020.09.001
Publication status	Published - Jan 2021

Keywords

Cutaneous melanoma
Liver directed therapy
Liver metastasis
Local therapy
Mucosal melanoma
Surgery
Systematic review
Uveal melanoma

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10.1016/j.soc.2020.09.001

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title = "An Overview of Liver Directed Locoregional Therapies",

abstract = "An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.",

keywords = "Cutaneous melanoma, Liver directed therapy, Liver metastasis, Local therapy, Mucosal melanoma, Surgery, Systematic review, Uveal melanoma",

author = "H{\"o}ppener, {Diederik J.} and Gr{\"u}nhagen, {Dirk J.} and Eggermont, {Alexander M.M.} and {van der Veldt}, {Astrid A.M.} and Cornelis Verhoef",

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doi = "10.1016/j.soc.2020.09.001",

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AU - Verhoef, Cornelis

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AB - An overview of all liver-directed locoregional therapies, including surgical resection for melanoma liver metastases (MLMs), is provided. MLM patients are divided by their primary melanoma location; cutaneous, uvea (eye), and mucosal melanoma. If patients with isolated cutaneous MLMs are considered for surgical resection, treatment with systemic therapy should be part of the treatment course. For uveal MLMs, complete surgical or ablative treatment of all MLMs suggests superior results compared with other liver-directed or systemic therapies, based on current evidence, no recommendations for any liver-directed regional therapy in the treatment of mucosal MLMs can be made.

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An Overview of Liver Directed Locoregional Therapies

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Keywords

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