An Update on the Histology of Pheochromocytomas: How Does it Relate to Genetics?

Lindsey Oudijk, José Gaal, Karen Koopman, Ronald R. De Krijger

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Pheochromocytomas are rare neuroendocrine tumors of the adrenal gland, whereas any extra-adrenal tumor with similar histology is designated as paraganglioma. These tumors have a very high rate of germline mutations in a large number of genes, up to 35% to 40%, frequently predisposing for other tumors as well. Therefore, they represent a phenomenal challenge for treating physicians. This review focuses on pheochromocytomas only, with special attention to gross and microscopic clues to the diagnosis of genetic syndromes, including the role of succinate dehydrogenase subunit A and subunit B immunohistochemistry as surrogate markers for genetic analysis in the field of succinate dehydrogenase subunit gene mutations.

Original languageEnglish
Pages (from-to)403-413
Number of pages11
JournalHormone and Metabolic Research
Volume51
Issue number7
DOIs
Publication statusPublished - 2019

Keywords

  • genetics
  • histology
  • pheochromocytoma

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