Anthracycline resistance in childhood leukemia

G. J.L. Kaspers; E. Klumper; R. Pieters; A. J.P. Veerman

Anthracycline resistance in childhood leukemia

G. J.L. Kaspers
, E. Klumper
, R. Pieters
, A. J.P. Veerman

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical resistance to anthracyclines, and the cardiotoxicity associated with the use of the conventional drugs daunorubicin (DNR) and doxorubicin (DOX), initiated the search for new analogues and structurally related drugs. We, use the cell culture drug resistance MTT assay to study the in vitro cytotoxicity of anthracyclines in childhood leukemia. Here, we summarize our results regarding these agents. We also report that relapsed ALL samples were significantly more resistant to DNR, DOX, and mitoxantrone (MIT) than untreated ALL samples, while the antileukemic activity of idarubicin (IDR) and especially of aclarubicin (ACR) was not significantly decreased in relapsed ALL.

Original language	English
Pages (from-to)	S158-S159
Journal	Bone Marrow Transplantation
Volume	12
Issue number	SUPPL. 4
Publication status	Published - 1993
Externally published	Yes

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title = "Anthracycline resistance in childhood leukemia",

abstract = "Clinical resistance to anthracyclines, and the cardiotoxicity associated with the use of the conventional drugs daunorubicin (DNR) and doxorubicin (DOX), initiated the search for new analogues and structurally related drugs. We, use the cell culture drug resistance MTT assay to study the in vitro cytotoxicity of anthracyclines in childhood leukemia. Here, we summarize our results regarding these agents. We also report that relapsed ALL samples were significantly more resistant to DNR, DOX, and mitoxantrone (MIT) than untreated ALL samples, while the antileukemic activity of idarubicin (IDR) and especially of aclarubicin (ACR) was not significantly decreased in relapsed ALL.",

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year = "1993",

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AU - Kaspers, G. J.L.

AU - Klumper, E.

AU - Pieters, R.

AU - Veerman, A. J.P.

PY - 1993

Y1 - 1993

N2 - Clinical resistance to anthracyclines, and the cardiotoxicity associated with the use of the conventional drugs daunorubicin (DNR) and doxorubicin (DOX), initiated the search for new analogues and structurally related drugs. We, use the cell culture drug resistance MTT assay to study the in vitro cytotoxicity of anthracyclines in childhood leukemia. Here, we summarize our results regarding these agents. We also report that relapsed ALL samples were significantly more resistant to DNR, DOX, and mitoxantrone (MIT) than untreated ALL samples, while the antileukemic activity of idarubicin (IDR) and especially of aclarubicin (ACR) was not significantly decreased in relapsed ALL.

AB - Clinical resistance to anthracyclines, and the cardiotoxicity associated with the use of the conventional drugs daunorubicin (DNR) and doxorubicin (DOX), initiated the search for new analogues and structurally related drugs. We, use the cell culture drug resistance MTT assay to study the in vitro cytotoxicity of anthracyclines in childhood leukemia. Here, we summarize our results regarding these agents. We also report that relapsed ALL samples were significantly more resistant to DNR, DOX, and mitoxantrone (MIT) than untreated ALL samples, while the antileukemic activity of idarubicin (IDR) and especially of aclarubicin (ACR) was not significantly decreased in relapsed ALL.

UR - https://www.scopus.com/pages/publications/0027760989

M3 - Article

AN - SCOPUS:0027760989

SN - 0268-3369

VL - 12

SP - S158-S159

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - SUPPL. 4

ER -

Anthracycline resistance in childhood leukemia

Abstract

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