Abstract
Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is β-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/β-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/β-catenin.
| Original language | English |
|---|---|
| Pages (from-to) | 179-182 |
| Number of pages | 4 |
| Journal | Nature Cell Biology |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Mar 2003 |
| Externally published | Yes |