Armadillo takes the APC shuttle

Hans Clevers

doi:10.1038/35036424

Armadillo takes the APC shuttle

Hans Clevers

Research output: Contribution to journal › Short survey › peer-review

8 Citations (Scopus)

Abstract

Combined efforts of developmental biologists and cancer geneticists have outlined the canonical Wnt/Wingless (Wg) signalling pathway as we currently know it. At the heart of the pathway is the molecule β-catenin/Armadillo. Recent work has shown that the tumour suppressor adenomatous polyposis coli (APC) acts to shuttle β-catenin from the nucleus to the cytoplasm.

Original language	English
Pages (from-to)	E177-E178
Journal	Nature Cell Biology
Volume	2
Issue number	10
DOIs	https://doi.org/10.1038/35036424
Publication status	Published - Oct 2000
Externally published	Yes

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title = "Armadillo takes the APC shuttle",

abstract = "Combined efforts of developmental biologists and cancer geneticists have outlined the canonical Wnt/Wingless (Wg) signalling pathway as we currently know it. At the heart of the pathway is the molecule β-catenin/Armadillo. Recent work has shown that the tumour suppressor adenomatous polyposis coli (APC) acts to shuttle β-catenin from the nucleus to the cytoplasm.",

author = "Hans Clevers",

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AB - Combined efforts of developmental biologists and cancer geneticists have outlined the canonical Wnt/Wingless (Wg) signalling pathway as we currently know it. At the heart of the pathway is the molecule β-catenin/Armadillo. Recent work has shown that the tumour suppressor adenomatous polyposis coli (APC) acts to shuttle β-catenin from the nucleus to the cytoplasm.

UR - https://www.scopus.com/pages/publications/0034306162

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DO - 10.1038/35036424

M3 - Short survey

C2 - 11025675

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SN - 1465-7392

VL - 2

SP - E177-E178

JO - Nature Cell Biology

JF - Nature Cell Biology

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Armadillo takes the APC shuttle

Abstract

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