Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1

Kornelius Kerl; Natalia Moreno; Till Holsten; Julia Ahlfeld; Julius Mertins; Marc Hotfilder; Marcel Kool; Kerstin Bartelheim; Sabine Schleicher; Rupert Handgretinger; Ulrich Schüller; Michael Meisterernst; Michael C. Frühwald

doi:10.1002/ijc.28719

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1

Kornelius Kerl, Natalia Moreno, Till Holsten, Julia Ahlfeld, Julius Mertins, Marc Hotfilder, Marcel Kool, Kerstin Bartelheim, Sabine Schleicher, Rupert Handgretinger, Ulrich Schüller, Michael Meisterernst, Michael C. Frühwald

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.

Original language	English
Pages (from-to)	989-995
Number of pages	7
Journal	International Journal of Cancer
Volume	135
Issue number	4
DOIs	https://doi.org/10.1002/ijc.28719
Publication status	Published - 15 Aug 2014
Externally published	Yes

Keywords

arsenic trioxide
Gli1
rhabdoid tumors
Sonic hedgehog

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10.1002/ijc.28719

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Kerl, K., Moreno, N., Holsten, T., Ahlfeld, J., Mertins, J., Hotfilder, M., Kool, M., Bartelheim, K., Schleicher, S., Handgretinger, R., Schüller, U., Meisterernst, M., & Frühwald, M. C. (2014). Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1. International Journal of Cancer, 135(4), 989-995. https://doi.org/10.1002/ijc.28719

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title = "Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1",

abstract = "Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.",

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author = "Kornelius Kerl and Natalia Moreno and Till Holsten and Julia Ahlfeld and Julius Mertins and Marc Hotfilder and Marcel Kool and Kerstin Bartelheim and Sabine Schleicher and Rupert Handgretinger and Ulrich Sch{\"u}ller and Michael Meisterernst and Fr{\"u}hwald, {Michael C.}",

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Kerl, K, Moreno, N, Holsten, T, Ahlfeld, J, Mertins, J, Hotfilder, M, Kool, M, Bartelheim, K, Schleicher, S, Handgretinger, R, Schüller, U, Meisterernst, M & Frühwald, MC 2014, 'Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1', International Journal of Cancer, vol. 135, no. 4, pp. 989-995. https://doi.org/10.1002/ijc.28719

TY - JOUR

T1 - Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1

AU - Kerl, Kornelius

AU - Moreno, Natalia

AU - Holsten, Till

AU - Ahlfeld, Julia

AU - Mertins, Julius

AU - Hotfilder, Marc

AU - Kool, Marcel

AU - Bartelheim, Kerstin

AU - Schleicher, Sabine

AU - Handgretinger, Rupert

AU - Schüller, Ulrich

AU - Meisterernst, Michael

AU - Frühwald, Michael C.

PY - 2014/8/15

Y1 - 2014/8/15

N2 - Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.

AB - Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.

KW - arsenic trioxide

KW - Gli1

KW - rhabdoid tumors

KW - Sonic hedgehog

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U2 - 10.1002/ijc.28719

DO - 10.1002/ijc.28719

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SN - 0020-7136

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SP - 989

EP - 995

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 4

ER -

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1

Abstract

Keywords

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