Asparagine synthetase activity in paediatric acute leukaemias: AML-M5 subtype shows lowest activity

A. Dübbers, G. Würthwein, H. J. Müller, P. Schulze-Westhoff, M. Winkelhorst, E. Kurzknabe, C. Lanvers, R. Pieters, G. J.L. Kaspers, U. Creutzig, J. Ritter, J. Boos

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44 Citations (Scopus)

Abstract

Lack of sufficient cellular activity of asparagine synthetase (AS) in blast cells compared with normal tissue is thought to be the basis of the antileukaemic effect of L-asparaginase in acute lymphoblastic leukaemia (ALL). Although L-asparaginase is routinely used in ALL, its role and value in the treatment of acute myelogenous leukaemia (AML) is still being discussed. To evaluate the pharmacological basis for L-asparaginase treatment, we established pretreatment monitoring of the intracellular AS activity in blast cells of patients with AML and ALL. There was no general difference in AS activity between ALL and AML samples. Significantly lower AS activity, however, was found in the B-lineage ALL subgroups as well as AML- M5.

Original languageEnglish
Pages (from-to)427-429
Number of pages3
JournalBritish Journal of Haematology
Volume109
Issue number2
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Acute lymphoblastic leukaemia
  • Acute myelogenous leukaemia
  • Asparaginase
  • Asparagine synthetase
  • Childhood leukaemia

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