Assessment of drug-induced immunotoxicity in animal models

Femke van Wijk; Stefan Nierkens

doi:10.1016/j.ddtec.2006.03.003

Assessment of drug-induced immunotoxicity in animal models

Femke van Wijk, Stefan Nierkens

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Drug Discovery Today: Technologies
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.ddtec.2006.03.003
Publication status	Published - 2006
Externally published	Yes

Access to Document

10.1016/j.ddtec.2006.03.003

Cite this

@article{9a7a60704e654d84947b5fe4f9e2fab6,

title = "Assessment of drug-induced immunotoxicity in animal models",

abstract = "With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.",

author = "{van Wijk}, Femke and Stefan Nierkens",

year = "2006",

doi = "10.1016/j.ddtec.2006.03.003",

language = "English",

volume = "3",

pages = "103--109",

journal = "Drug Discovery Today: Technologies",

issn = "1740-6749",

publisher = "Elsevier Ltd.",

number = "1",

}

TY - JOUR

T1 - Assessment of drug-induced immunotoxicity in animal models

AU - van Wijk, Femke

AU - Nierkens, Stefan

PY - 2006

Y1 - 2006

N2 - With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.

AB - With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.

UR - http://www.scopus.com/inward/record.url?scp=33646010909&partnerID=8YFLogxK

U2 - 10.1016/j.ddtec.2006.03.003

DO - 10.1016/j.ddtec.2006.03.003

M3 - Review article

AN - SCOPUS:33646010909

SN - 1740-6749

VL - 3

SP - 103

EP - 109

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

IS - 1

ER -

Assessment of drug-induced immunotoxicity in animal models

Abstract

Access to Document

Fingerprint

Cite this