Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats

E. R. Manusama; P. T.G.A. Nooijen; J. Stavast; J. H.W. De Wilt; R. L. Marquet; A. M.M. Eggermont

doi:10.1006/jsre.1997.5256

Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats

E. R. Manusama
, P. T.G.A. Nooijen
, J. Stavast
, J. H.W. De Wilt
, R. L. Marquet
, A. M.M. Eggermont

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.

Original language	English
Pages (from-to)	169-175
Number of pages	7
Journal	Journal of Surgical Research
Volume	78
Issue number	2
DOIs	https://doi.org/10.1006/jsre.1997.5256
Publication status	Published - Aug 1998
Externally published	Yes

Keywords

Chemotherapy
Oncology

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10.1006/jsre.1997.5256

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title = "Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats",

abstract = "Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.",

keywords = "Chemotherapy, Oncology",

author = "Manusama, \{E. R.\} and Nooijen, \{P. T.G.A.\} and J. Stavast and \{De Wilt\}, \{J. H.W.\} and Marquet, \{R. L.\} and Eggermont, \{A. M.M.\}",

note = "Funding Information: This work was {\textregistered}nanced in part by the Dutch Cancer Society (Grant DDHK 93-659). We acknowledge Boehringer Ingelheim GmbH for generously providing TNFα. We thank Mr. W. P. van Schalkwijk for performing the in vitro platelet aggregations experiments and Mr.",

year = "1998",

month = aug,

doi = "10.1006/jsre.1997.5256",

language = "English",

volume = "78",

pages = "169--175",

journal = "Journal of Surgical Research",

issn = "0022-4804",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats

AU - Manusama, E. R.

AU - Nooijen, P. T.G.A.

AU - Stavast, J.

AU - De Wilt, J. H.W.

AU - Marquet, R. L.

AU - Eggermont, A. M.M.

N1 - Funding Information: This work was ®nanced in part by the Dutch Cancer Society (Grant DDHK 93-659). We acknowledge Boehringer Ingelheim GmbH for generously providing TNFα. We thank Mr. W. P. van Schalkwijk for performing the in vitro platelet aggregations experiments and Mr.

PY - 1998/8

Y1 - 1998/8

N2 - Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.

AB - Introduction. Isolated limb perfusion (ILP) with TNFα in combination with melphalan and IFNγ/has resulted in an immediate and dramatic tumor response in patients. Such an effect was also noted following ILP in a rat sarcoma model. This model enables us to investigate several factors responsible for the TNFα-induced tumor responses. We applied total body irradiation (TBI) to reduce white blood cell count, to investigate the contribution of leukocytes to the antitumor effect of TNFα.

KW - Chemotherapy

KW - Oncology

UR - https://www.scopus.com/pages/publications/0344906175

U2 - 10.1006/jsre.1997.5256

DO - 10.1006/jsre.1997.5256

M3 - Article

C2 - 9733636

AN - SCOPUS:0344906175

SN - 0022-4804

VL - 78

SP - 169

EP - 175

JO - Journal of Surgical Research

JF - Journal of Surgical Research

IS - 2

ER -

Assessment of the role of neutrophils on the antitumor effect of TNFα in an in vivo isolated limb perfusion model sarcoma-bearing brown Norway rats

Abstract

Keywords

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