Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC

Willem J.A. Witlox, Bram L.T. Ramaekers, Benjamin Lacas, Cecile Le Pechoux, Alexander Sun, Si Yu Wang, Chen Hu, Mary Redman, Vincent van der Noort, Ning Li, Matthias Guckenberger, Harm van Tinteren, Harry J.M. Groen, Manuela A. Joore, Dirk K.M. De Ruysscher

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalRadiotherapy and Oncology
Volume164
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Brain metastases-free survival
  • Non-small cell lung cancer
  • Prophylactic cranial irradiation
  • Toxicity

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