Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC

Willem J.A. Witlox; Bram L.T. Ramaekers; Benjamin Lacas; Cecile Le Pechoux; Alexander Sun; Si Yu Wang; Chen Hu; Mary Redman; Vincent van der Noort; Ning Li; Matthias Guckenberger; Harm van Tinteren; Harry J.M. Groen; Manuela A. Joore; Dirk K.M. De Ruysscher

doi:10.1016/j.radonc.2021.09.029

Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC

Willem J.A. Witlox
, Bram L.T. Ramaekers
, Benjamin Lacas
, Cecile Le Pechoux
, Alexander Sun
, Si Yu Wang
, Chen Hu
, Mary Redman
, Vincent van der Noort
, Ning Li
, Matthias Guckenberger
, Harm van Tinteren
, Harry J.M. Groen
, Manuela A. Joore
, Dirk K.M. De Ruysscher

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Research output: Contribution to journal › Article › peer-review

Abstract

We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

Original language	English
Pages (from-to)	163-166
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	164
DOIs	https://doi.org/10.1016/j.radonc.2021.09.029
Publication status	Published - Nov 2021

Keywords

Brain metastases-free survival
Non-small cell lung cancer
Prophylactic cranial irradiation
Toxicity

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Witlox, W. J. A., Ramaekers, B. L. T., Lacas, B., Pechoux, C. L., Sun, A., Wang, S. Y., Hu, C., Redman, M., van der Noort, V., Li, N., Guckenberger, M., van Tinteren, H., Groen, H. J. M., Joore, M. A., & De Ruysscher, D. K. M. (2021). Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC. Radiotherapy and Oncology, 164, 163-166. https://doi.org/10.1016/j.radonc.2021.09.029

Witlox, Willem J.A. ; Ramaekers, Bram L.T. ; Lacas, Benjamin et al. / Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer : A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC. In: Radiotherapy and Oncology. 2021 ; Vol. 164. pp. 163-166.

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title = "Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC",

abstract = "We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.",

keywords = "Brain metastases-free survival, Non-small cell lung cancer, Prophylactic cranial irradiation, Toxicity",

author = "Witlox, \{Willem J.A.\} and Ramaekers, \{Bram L.T.\} and Benjamin Lacas and Pechoux, \{Cecile Le\} and Alexander Sun and Wang, \{Si Yu\} and Chen Hu and Mary Redman and \{van der Noort\}, Vincent and Ning Li and Matthias Guckenberger and \{van Tinteren\}, Harm and Groen, \{Harry J.M.\} and Joore, \{Manuela A.\} and \{De Ruysscher\}, \{Dirk K.M.\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = nov,

doi = "10.1016/j.radonc.2021.09.029",

language = "English",

volume = "164",

pages = "163--166",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

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Witlox, WJA, Ramaekers, BLT, Lacas, B, Pechoux, CL, Sun, A, Wang, SY, Hu, C, Redman, M, van der Noort, V, Li, N, Guckenberger, M, van Tinteren, H, Groen, HJM, Joore, MA & De Ruysscher, DKM 2021, 'Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC', Radiotherapy and Oncology, vol. 164, pp. 163-166. https://doi.org/10.1016/j.radonc.2021.09.029

Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC. / Witlox, Willem J.A.; Ramaekers, Bram L.T.; Lacas, Benjamin et al.
In: Radiotherapy and Oncology, Vol. 164, 11.2021, p. 163-166.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer

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AU - Witlox, Willem J.A.

AU - Ramaekers, Bram L.T.

AU - Lacas, Benjamin

AU - Pechoux, Cecile Le

AU - Sun, Alexander

AU - Wang, Si Yu

AU - Hu, Chen

AU - Redman, Mary

AU - van der Noort, Vincent

AU - Li, Ning

AU - Guckenberger, Matthias

AU - van Tinteren, Harm

AU - Groen, Harry J.M.

AU - Joore, Manuela A.

AU - De Ruysscher, Dirk K.M.

PY - 2021/11

Y1 - 2021/11

N2 - We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

AB - We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.

KW - Brain metastases-free survival

KW - Non-small cell lung cancer

KW - Prophylactic cranial irradiation

KW - Toxicity

UR - https://www.scopus.com/pages/publications/85116762794

U2 - 10.1016/j.radonc.2021.09.029

DO - 10.1016/j.radonc.2021.09.029

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AN - SCOPUS:85116762794

SN - 0167-8140

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SP - 163

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JF - Radiotherapy and Oncology

ER -

Witlox WJA, Ramaekers BLT, Lacas B, Pechoux CL, Sun A, Wang SY et al. Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials: Association of different PCI schedules with toxicity and BMFS in stage III NSCLC. Radiotherapy and Oncology. 2021 Nov;164:163-166. doi: 10.1016/j.radonc.2021.09.029