B-cell recovery after stem cell transplantation of Artemis-deficient SCID requires elimination of autologous bone marrow precursor-B-cells

Mirjam Van Der Burg; Corry M.R. Weemaes; Frank Preijers; Paul Brons; Barbara H. Barendregt; Maarten J.D. Van Tol; Peter Hoogerbrugge; Jacques J.M. Van Dongen

B-cell recovery after stem cell transplantation of Artemis-deficient SCID requires elimination of autologous bone marrow precursor-B-cells

Mirjam Van Der Burg, Corry M.R. Weemaes, Frank Preijers, Paul Brons, Barbara H. Barendregt, Maarten J.D. Van Tol, Peter Hoogerbrugge, Jacques J.M. Van Dongen

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Severe combined immunodeficiencies (SCID) are commonly fatal early in life. Adequate diagnosis and rapid institution of treatment, such as allogeneic stem cell transplantation (SCT), is essential. Several studies demonstrated that reconstitution of B-cell function after SCT is better in B-positive SCID than in B-negative SCID. We demonstrate that B-cell reconstitution in a B-negative SCID patient due to an Artemis mutation required the elimination of the autologous precursor-B-cells in bone marrow, probably to create physical space in the precursor-B-cell niches. Apparently, occupation of the precursor-B-cell niches is a potential dominant factor influencing repopulation of a functional B-cell compartment in B-negative SCID.

Original language	English
Pages (from-to)	1705-1709
Number of pages	5
Journal	Haematologica
Volume	91
Issue number	12
Publication status	Published - Dec 2006
Externally published	Yes

Keywords

Artemis-deficient SCID
B-cell recovery
Stem cell transplantation

Cite this

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title = "B-cell recovery after stem cell transplantation of Artemis-deficient SCID requires elimination of autologous bone marrow precursor-B-cells",

abstract = "Severe combined immunodeficiencies (SCID) are commonly fatal early in life. Adequate diagnosis and rapid institution of treatment, such as allogeneic stem cell transplantation (SCT), is essential. Several studies demonstrated that reconstitution of B-cell function after SCT is better in B-positive SCID than in B-negative SCID. We demonstrate that B-cell reconstitution in a B-negative SCID patient due to an Artemis mutation required the elimination of the autologous precursor-B-cells in bone marrow, probably to create physical space in the precursor-B-cell niches. Apparently, occupation of the precursor-B-cell niches is a potential dominant factor influencing repopulation of a functional B-cell compartment in B-negative SCID.",

keywords = "Artemis-deficient SCID, B-cell recovery, Stem cell transplantation",

author = "{Van Der Burg}, Mirjam and Weemaes, {Corry M.R.} and Frank Preijers and Paul Brons and Barendregt, {Barbara H.} and {Van Tol}, {Maarten J.D.} and Peter Hoogerbrugge and {Van Dongen}, {Jacques J.M.}",

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TY - JOUR

T1 - B-cell recovery after stem cell transplantation of Artemis-deficient SCID requires elimination of autologous bone marrow precursor-B-cells

AU - Van Der Burg, Mirjam

AU - Weemaes, Corry M.R.

AU - Preijers, Frank

AU - Brons, Paul

AU - Barendregt, Barbara H.

AU - Van Tol, Maarten J.D.

AU - Hoogerbrugge, Peter

AU - Van Dongen, Jacques J.M.

PY - 2006/12

Y1 - 2006/12

N2 - Severe combined immunodeficiencies (SCID) are commonly fatal early in life. Adequate diagnosis and rapid institution of treatment, such as allogeneic stem cell transplantation (SCT), is essential. Several studies demonstrated that reconstitution of B-cell function after SCT is better in B-positive SCID than in B-negative SCID. We demonstrate that B-cell reconstitution in a B-negative SCID patient due to an Artemis mutation required the elimination of the autologous precursor-B-cells in bone marrow, probably to create physical space in the precursor-B-cell niches. Apparently, occupation of the precursor-B-cell niches is a potential dominant factor influencing repopulation of a functional B-cell compartment in B-negative SCID.

AB - Severe combined immunodeficiencies (SCID) are commonly fatal early in life. Adequate diagnosis and rapid institution of treatment, such as allogeneic stem cell transplantation (SCT), is essential. Several studies demonstrated that reconstitution of B-cell function after SCT is better in B-positive SCID than in B-negative SCID. We demonstrate that B-cell reconstitution in a B-negative SCID patient due to an Artemis mutation required the elimination of the autologous precursor-B-cells in bone marrow, probably to create physical space in the precursor-B-cell niches. Apparently, occupation of the precursor-B-cell niches is a potential dominant factor influencing repopulation of a functional B-cell compartment in B-negative SCID.

KW - Artemis-deficient SCID

KW - B-cell recovery

KW - Stem cell transplantation

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M3 - Article

C2 - 17145611

AN - SCOPUS:33845954952

SN - 0390-6078

VL - 91

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JO - Haematologica

JF - Haematologica

IS - 12

ER -

B-cell recovery after stem cell transplantation of Artemis-deficient SCID requires elimination of autologous bone marrow precursor-B-cells

Abstract

Keywords

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