Behandeling van HIV-infecties. De schuilplaatsen van het virus

Translated title of the contribution: The hiding places for the virus. Treatment of HIV infections

J. H. Beumer, A. D.R. Huitema, E. C.M. Van Gorp, J. H. Beijnen

Research output: Contribution to journalArticlepeer-review

Abstract

The introduction of Highly Active Anti-Retroviral Therapy (HAART) for the treatment of an HIV infection in 1996 has resulted in an enormous reduction of morbidity and mortality. Complete eradication of virus is, however, not yet possible. Sanctuary sites appear to be of paramount importance in the failure of eradication of HIV. A sanctuary site is a cell or an organ with reduced susceptibility of HIV to antiretroviral therapy. Inadequate availability of (the active form of) drugs at the site of action due to efflux pumps such as P-glycoprotein (Pgp) or inadequate bioactivation and the presence of latent virus (with reduced susceptibility to therapy) may be mechanisms that result in sanctuary sites. CD4+ memory cells, macrophages, follicular dendritic cells, the central nervous system and testes are examples of these sanctuary sites. Use of Pgp inhibitors and CD4+ activators may contribute to circumvent these sites and may aid to eradicate the last virus particles. The existence of sanctuary sites may also enhance the development of resistant virus. Therapy directed at eradication of virus in these sanctuary sites may thus form an important improvement in the treatment of HIV-infected patients.

Translated title of the contributionThe hiding places for the virus. Treatment of HIV infections
Original languageDutch
Pages (from-to)238-242
Number of pages5
JournalPharmaceutisch Weekblad
Volume137
Issue number7
Publication statusPublished - 15 Feb 2002
Externally publishedYes

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