Biology and Treatment of Acute Lymphoblastic Leukemia

Rob Pieters, William L. Carroll

Research output: Contribution to journalReview articlepeer-review

83 Citations (Scopus)


Acute lymphoblastic leukemia (ALL), the most common type of cancer in children, is a heterogeneous disease in which many genetic lesions result in the development of multiple biologic subtypes. Today, with intensive multiagent chemotherapy, most children who have ALL are cured. The many national or institutional ALL therapy protocols in use tend to stratify patients in a multitude of different ways to tailor treatment to the rate of relapse. This article discusses the factors used in risk stratification and the treatment of pediatric ALL.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalHematology/Oncology Clinics of North America
Issue number1
Publication statusPublished - Feb 2010
Externally publishedYes


  • Acute lymphoblastic leukemia
  • Adolescents
  • Chemotherapy
  • Children
  • Genomics
  • Targeted therapy


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