Blood platelets contain tumor-derived RNA biomarkers

Jonas Nilsson; Leonora Balaj; Esther Hulleman; Sjoerd van Rijn; D. Michiel Pegtel; Maudy Walraven; Anders Widmark; Winald R. Gerritsen; Henk M. Verheul; William P. Vandertop; David P. Noske; Johan Skog; Thomas Wurdinger

doi:10.1182/blood-2011-03-344408

Blood platelets contain tumor-derived RNA biomarkers

Jonas Nilsson, Leonora Balaj, Esther Hulleman, Sjoerd van Rijn, D. Michiel Pegtel, Maudy Walraven, Anders Widmark, Winald R. Gerritsen, Henk M. Verheul, William P. Vandertop, David P. Noske, Johan Skog, Thomas Wurdinger

Research output: Contribution to journal › Article › peer-review

310 Citations (Scopus)

Abstract

Diagnostic platforms providing biomarkers that are highly predictive for diagnosing, monitoring, and stratifying cancer patients are key instruments in the development of personalized medicine. We demonstrate that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and show that blood platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively. In addition, gene-expression profiling revealed a distinct RNA signature in platelets from glioma patients compared with normal control subjects. Because platelets are easily accessible and isolated, they may form an attractive platform for the companion diagnostics of cancer.

Original language	English
Pages (from-to)	3680-3683
Number of pages	4
Journal	Blood
Volume	118
Issue number	3
DOIs	https://doi.org/10.1182/blood-2011-03-344408
Publication status	Published - 29 Sept 2011
Externally published	Yes

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title = "Blood platelets contain tumor-derived RNA biomarkers",

abstract = "Diagnostic platforms providing biomarkers that are highly predictive for diagnosing, monitoring, and stratifying cancer patients are key instruments in the development of personalized medicine. We demonstrate that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and show that blood platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively. In addition, gene-expression profiling revealed a distinct RNA signature in platelets from glioma patients compared with normal control subjects. Because platelets are easily accessible and isolated, they may form an attractive platform for the companion diagnostics of cancer.",

author = "Jonas Nilsson and Leonora Balaj and Esther Hulleman and {van Rijn}, Sjoerd and Pegtel, {D. Michiel} and Maudy Walraven and Anders Widmark and Gerritsen, {Winald R.} and Verheul, {Henk M.} and Vandertop, {William P.} and Noske, {David P.} and Johan Skog and Thomas Wurdinger",

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doi = "10.1182/blood-2011-03-344408",

language = "English",

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T1 - Blood platelets contain tumor-derived RNA biomarkers

AU - Nilsson, Jonas

AU - Balaj, Leonora

AU - Hulleman, Esther

AU - van Rijn, Sjoerd

AU - Pegtel, D. Michiel

AU - Walraven, Maudy

AU - Widmark, Anders

AU - Gerritsen, Winald R.

AU - Verheul, Henk M.

AU - Vandertop, William P.

AU - Noske, David P.

AU - Skog, Johan

AU - Wurdinger, Thomas

PY - 2011/9/29

Y1 - 2011/9/29

N2 - Diagnostic platforms providing biomarkers that are highly predictive for diagnosing, monitoring, and stratifying cancer patients are key instruments in the development of personalized medicine. We demonstrate that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and show that blood platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively. In addition, gene-expression profiling revealed a distinct RNA signature in platelets from glioma patients compared with normal control subjects. Because platelets are easily accessible and isolated, they may form an attractive platform for the companion diagnostics of cancer.

AB - Diagnostic platforms providing biomarkers that are highly predictive for diagnosing, monitoring, and stratifying cancer patients are key instruments in the development of personalized medicine. We demonstrate that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and show that blood platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively. In addition, gene-expression profiling revealed a distinct RNA signature in platelets from glioma patients compared with normal control subjects. Because platelets are easily accessible and isolated, they may form an attractive platform for the companion diagnostics of cancer.

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U2 - 10.1182/blood-2011-03-344408

DO - 10.1182/blood-2011-03-344408

M3 - Article

SN - 0006-4971

VL - 118

SP - 3680

EP - 3683

JO - Blood

JF - Blood

IS - 3

ER -

Blood platelets contain tumor-derived RNA biomarkers

Abstract

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