@article{6d5bac50e69c4454b968386b59aee0e8,
title = "Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting",
abstract = "Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.",
author = "Hogan, \{Benjamin M.\} and Bos, \{Frank L.\} and Jeroen Bussmann and Merlijn Witte and Chi, \{Neil C.\} and Duckers, \{Henricus J.\} and Stefan Schulte-Merker",
note = "Funding Information: B.M.H. was supported by an EMBO long term fellowship and an NH\&MRC CJ Martin Fellowship and J.B. by the Stichting Vrienden van het Hubrecht. N.C.C. is supported by K08 grants from the NHLBI, GSK Research \& Education Foundation Cardiovascular Awards, and Fellow to Faculty AHA postdoctoral awards. N.C.C. also thanks D. Stainier for support. H.J.D. received an NWO VIDI grant. The authors thank the Hubrecht Screen Team, J. Korving for sectioning, R. Korswagen, A. MacInnes, K. Smith and H. Clevers for critical reading of the manuscript.",
year = "2009",
month = apr,
doi = "10.1038/ng.321",
language = "English",
volume = "41",
pages = "396--398",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "4",
}