Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Benjamin M. Hogan; Frank L. Bos; Jeroen Bussmann; Merlijn Witte; Neil C. Chi; Henricus J. Duckers; Stefan Schulte-Merker

doi:10.1038/ng.321

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Benjamin M. Hogan
, Frank L. Bos
, Jeroen Bussmann
, Merlijn Witte
, Neil C. Chi
, Henricus J. Duckers
, Stefan Schulte-Merker

Research output: Contribution to journal › Article › peer-review

398 Citations (Scopus)

Abstract

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

Original language	English
Pages (from-to)	396-398
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	4
DOIs	https://doi.org/10.1038/ng.321
Publication status	Published - Apr 2009
Externally published	Yes

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title = "Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting",

abstract = "Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.",

author = "Hogan, \{Benjamin M.\} and Bos, \{Frank L.\} and Jeroen Bussmann and Merlijn Witte and Chi, \{Neil C.\} and Duckers, \{Henricus J.\} and Stefan Schulte-Merker",

note = "Funding Information: B.M.H. was supported by an EMBO long term fellowship and an NH\&MRC CJ Martin Fellowship and J.B. by the Stichting Vrienden van het Hubrecht. N.C.C. is supported by K08 grants from the NHLBI, GSK Research \& Education Foundation Cardiovascular Awards, and Fellow to Faculty AHA postdoctoral awards. N.C.C. also thanks D. Stainier for support. H.J.D. received an NWO VIDI grant. The authors thank the Hubrecht Screen Team, J. Korving for sectioning, R. Korswagen, A. MacInnes, K. Smith and H. Clevers for critical reading of the manuscript.",

year = "2009",

month = apr,

doi = "10.1038/ng.321",

language = "English",

volume = "41",

pages = "396--398",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "4",

}

TY - JOUR

T1 - Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

AU - Hogan, Benjamin M.

AU - Bos, Frank L.

AU - Bussmann, Jeroen

AU - Witte, Merlijn

AU - Chi, Neil C.

AU - Duckers, Henricus J.

AU - Schulte-Merker, Stefan

N1 - Funding Information: B.M.H. was supported by an EMBO long term fellowship and an NH&MRC CJ Martin Fellowship and J.B. by the Stichting Vrienden van het Hubrecht. N.C.C. is supported by K08 grants from the NHLBI, GSK Research & Education Foundation Cardiovascular Awards, and Fellow to Faculty AHA postdoctoral awards. N.C.C. also thanks D. Stainier for support. H.J.D. received an NWO VIDI grant. The authors thank the Hubrecht Screen Team, J. Korving for sectioning, R. Korswagen, A. MacInnes, K. Smith and H. Clevers for critical reading of the manuscript.

PY - 2009/4

Y1 - 2009/4

N2 - Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

AB - Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

UR - https://www.scopus.com/pages/publications/63449128207

U2 - 10.1038/ng.321

DO - 10.1038/ng.321

M3 - Article

C2 - 19287381

AN - SCOPUS:63449128207

SN - 1061-4036

VL - 41

SP - 396

EP - 398

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Abstract

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