TY - JOUR
T1 - Characteristics and outcome of children with renal tumors in the Netherlands
T2 - The first five-year's experience of national centralization
AU - Roy, Prakriti
AU - van Peer, Sophie E
AU - de Witte, Martin M
AU - Tytgat, Godelieve A M
AU - Karim-Kos, Henrike E
AU - van Grotel, Martine
AU - van de Ven, Cees P
AU - Mavinkurve-Groothuis, Annelies M C
AU - Merks, Johannes H M
AU - Kuiper, Roland P
AU - Hol, Janna A
AU - Janssens, Geert O R
AU - de Krijger, Ronald R
AU - Jongmans, Marjolijn C J
AU - Drost, Jarno
AU - van der Steeg, Alida F W
AU - Littooij, Annemieke S
AU - Wijnen, Marc H W A
AU - van Tinteren, Harm
AU - van den Heuvel-Eibrink, Marry M
N1 - Publisher Copyright:
© 2022 Roy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/1
Y1 - 2022/1
N2 - Around 6% of all childhood malignancies represent renal tumors, of which a majority includes Wilms tumor (WT). Although survival rates have improved over the last decades, specific patients are still at risk for adverse outcome. In the Netherlands, since 2015, pediatric oncology care for renal tumors has been centralized in the Princess Máxima Center for Pediatric Oncology. Here, we describe experiences of the first 5 years of centralized care and explore whether this influences the epidemiological landscape by comparing data with the Netherlands Cancer Registry (NCR). We identified all patients <19 years with a renal mass diagnosed between 01-01-2015 and 31-12-2019 in the Princess Máxima Center. Epidemiology, characteristics and management were analyzed. We identified 164 patients (including 1 patient who refused consent for registration), in our center with a suspicion of a renal tumor. The remaining 163 cases included WT (n = 118)/cystic partially differentiated nephroblastoma (n = 2)/nephrogenic rests only (n = 6) and non-WT (n = 37). In this period, the NCR included 138 children, 1 17-year-old patient was not referred to the Princess Máxima Center. Central radiology review (before starting treatment) was performed in 121/163 patients, and central pathology review in 148/152 patients that underwent surgery. Treatment stratification, according to SIOP/EpSSG protocols was pursued based on multidisciplinary consensus. Preoperative chemotherapy was administered in 133 patients, whereas 19 patients underwent upfront surgery. Surgery was performed in 152 patients, and from 133 biomaterial was stored. Centralization of care for children with renal tumors led to referral of all but 1 new renal tumor cases in the Netherlands, and leads to referral of very rare subtypes not registered in the NCR, that benefit from high quality diagnostics and multidisciplinary decision making. National centralization of care led to enhanced development of molecular diagnostics and other innovation-based treatments for the future.
AB - Around 6% of all childhood malignancies represent renal tumors, of which a majority includes Wilms tumor (WT). Although survival rates have improved over the last decades, specific patients are still at risk for adverse outcome. In the Netherlands, since 2015, pediatric oncology care for renal tumors has been centralized in the Princess Máxima Center for Pediatric Oncology. Here, we describe experiences of the first 5 years of centralized care and explore whether this influences the epidemiological landscape by comparing data with the Netherlands Cancer Registry (NCR). We identified all patients <19 years with a renal mass diagnosed between 01-01-2015 and 31-12-2019 in the Princess Máxima Center. Epidemiology, characteristics and management were analyzed. We identified 164 patients (including 1 patient who refused consent for registration), in our center with a suspicion of a renal tumor. The remaining 163 cases included WT (n = 118)/cystic partially differentiated nephroblastoma (n = 2)/nephrogenic rests only (n = 6) and non-WT (n = 37). In this period, the NCR included 138 children, 1 17-year-old patient was not referred to the Princess Máxima Center. Central radiology review (before starting treatment) was performed in 121/163 patients, and central pathology review in 148/152 patients that underwent surgery. Treatment stratification, according to SIOP/EpSSG protocols was pursued based on multidisciplinary consensus. Preoperative chemotherapy was administered in 133 patients, whereas 19 patients underwent upfront surgery. Surgery was performed in 152 patients, and from 133 biomaterial was stored. Centralization of care for children with renal tumors led to referral of all but 1 new renal tumor cases in the Netherlands, and leads to referral of very rare subtypes not registered in the NCR, that benefit from high quality diagnostics and multidisciplinary decision making. National centralization of care led to enhanced development of molecular diagnostics and other innovation-based treatments for the future.
KW - Adolescent
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Child
KW - Child, Preschool
KW - Dactinomycin
KW - Disease-Free Survival
KW - Humans
KW - Infant
KW - Kidney Neoplasms/diagnostic imaging
KW - Neoplasm Staging
KW - Netherlands
KW - Prognosis
KW - Treatment Outcome
KW - Vincristine
UR - http://www.scopus.com/inward/record.url?scp=85122860791&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/499eacdf-e8db-304f-bfc7-63dfca30a9bc/
U2 - 10.1371/journal.pone.0261729
DO - 10.1371/journal.pone.0261729
M3 - Article
C2 - 35025887
SN - 1932-6203
VL - 17
SP - e0261729
JO - PloS one
JF - PloS one
IS - 1 January
M1 - e0261729
ER -