Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7

Claudia M.J.M. Faaij; Annemieke J. Willemze; Tom Révész; Melania Balzarolo; Cornelis P. Tensen; Manja Hoogeboom; Maarten H. Vermeer; Elisabeth Van Wering; Christian M. Zwaan; Gertjan J.L. Kaspers; Colin Story; Astrid G.S. Van Halteren; Jaak M. Vossen; R. Maarten Egeler; Maarten J.D. Van Tol; Nicola E. Annels

doi:10.1002/pbc.22500

Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7

Claudia M.J.M. Faaij
, Annemieke J. Willemze
, Tom Révész
, Melania Balzarolo
, Cornelis P. Tensen
, Manja Hoogeboom
, Maarten H. Vermeer
, Elisabeth Van Wering
, Christian M. Zwaan
, Gertjan J.L. Kaspers
, Colin Story
, Astrid G.S. Van Halteren
, Jaak M. Vossen
, R. Maarten Egeler
, Maarten J.D. Van Tol
, Nicola E. Annels

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n=7), bone marrow (n=6), or skin (n=11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2^pos AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin.

Original language	English
Pages (from-to)	344-348
Number of pages	5
Journal	Pediatric Blood and Cancer
Volume	55
Issue number	2
DOIs	https://doi.org/10.1002/pbc.22500
Publication status	Published - Aug 2010
Externally published	Yes

Keywords

AML
Chemokines
Paediatric haematology/oncology

Access to Document

10.1002/pbc.22500

Cite this

Faaij, C. M. J. M., Willemze, A. J., Révész, T., Balzarolo, M., Tensen, C. P., Hoogeboom, M., Vermeer, M. H., Van Wering, E., Zwaan, C. M., Kaspers, G. J. L., Story, C., Van Halteren, A. G. S., Vossen, J. M., Egeler, R. M., Van Tol, M. J. D., & Annels, N. E. (2010). Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7. Pediatric Blood and Cancer, 55(2), 344-348. https://doi.org/10.1002/pbc.22500

@article{9c59c7e2de6342d1a6d31fa2ff5b6653,

title = "Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7",

abstract = "Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n=7), bone marrow (n=6), or skin (n=11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2pos AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin.",

keywords = "AML, Chemokines, Paediatric haematology/oncology",

author = "Faaij, \{Claudia M.J.M.\} and Willemze, \{Annemieke J.\} and Tom R{\'e}v{\'e}sz and Melania Balzarolo and Tensen, \{Cornelis P.\} and Manja Hoogeboom and Vermeer, \{Maarten H.\} and \{Van Wering\}, Elisabeth and Zwaan, \{Christian M.\} and Kaspers, \{Gertjan J.L.\} and Colin Story and \{Van Halteren\}, \{Astrid G.S.\} and Vossen, \{Jaak M.\} and Egeler, \{R. Maarten\} and \{Van Tol\}, \{Maarten J.D.\} and Annels, \{Nicola E.\}",

year = "2010",

month = aug,

doi = "10.1002/pbc.22500",

language = "English",

volume = "55",

pages = "344--348",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

number = "2",

}

Faaij, CMJM, Willemze, AJ, Révész, T, Balzarolo, M, Tensen, CP, Hoogeboom, M, Vermeer, MH, Van Wering, E, Zwaan, CM, Kaspers, GJL, Story, C, Van Halteren, AGS, Vossen, JM, Egeler, RM, Van Tol, MJD & Annels, NE 2010, 'Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7', Pediatric Blood and Cancer, vol. 55, no. 2, pp. 344-348. https://doi.org/10.1002/pbc.22500

TY - JOUR

T1 - Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML

T2 - Differential roles for CCR2, CCR5, CXCR4 and CXCR7

AU - Faaij, Claudia M.J.M.

AU - Willemze, Annemieke J.

AU - Révész, Tom

AU - Balzarolo, Melania

AU - Tensen, Cornelis P.

AU - Hoogeboom, Manja

AU - Vermeer, Maarten H.

AU - Van Wering, Elisabeth

AU - Zwaan, Christian M.

AU - Kaspers, Gertjan J.L.

AU - Story, Colin

AU - Van Halteren, Astrid G.S.

AU - Vossen, Jaak M.

AU - Egeler, R. Maarten

AU - Van Tol, Maarten J.D.

AU - Annels, Nicola E.

PY - 2010/8

Y1 - 2010/8

N2 - Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n=7), bone marrow (n=6), or skin (n=11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2pos AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin.

AB - Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n=7), bone marrow (n=6), or skin (n=11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2pos AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin.

KW - AML

KW - Chemokines

KW - Paediatric haematology/oncology

UR - https://www.scopus.com/pages/publications/77955100333

U2 - 10.1002/pbc.22500

DO - 10.1002/pbc.22500

M3 - Article

C2 - 20582977

AN - SCOPUS:77955100333

SN - 1545-5009

VL - 55

SP - 344

EP - 348

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 2

ER -

Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7

Abstract

Keywords

Access to Document

Fingerprint

Cite this