Chromosomal Changes in Human Primary Testicular Nonseminomatous Germ Cell Tumors

Sergio M.M.J. Castedo; Bauke de Jong; Raquel Seruca; Gerard te Meerman; Vera J.S. Idenburg; J. Wolter Oosterhuis; Anke Dam; Heimen Schraffordt Koops; Dirk T. Sleijfer

Chromosomal Changes in Human Primary Testicular Nonseminomatous Germ Cell Tumors

Sergio M.M.J. Castedo
, Bauke de Jong
, Raquel Seruca
, Gerard te Meerman
, Vera J.S. Idenburg
, J. Wolter Oosterhuis
, Anke Dam
, Heimen Schraffordt Koops
, Dirk T. Sleijfer

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

Abstract

A cytogenetic analysis of 14 primary testicular nonseminomatous germ cell tumors has been carried out after short term tissue culture. The modal chromosome numbers ranged from 53 to 113, in agreement with flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. Two tumors, however, lacked that marker. Some chromosomes are apparently overrepresented, whereas others are underrepresented, although some differences between seminomas and nonseminomas were noticed.

Original language	English
Pages (from-to)	5696-5701
Number of pages	6
Journal	Cancer Research
Volume	49
Issue number	20
Publication status	Published - 15 Oct 1989
Externally published	Yes

Cite this

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title = "Chromosomal Changes in Human Primary Testicular Nonseminomatous Germ Cell Tumors",

abstract = "A cytogenetic analysis of 14 primary testicular nonseminomatous germ cell tumors has been carried out after short term tissue culture. The modal chromosome numbers ranged from 53 to 113, in agreement with flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. Two tumors, however, lacked that marker. Some chromosomes are apparently overrepresented, whereas others are underrepresented, although some differences between seminomas and nonseminomas were noticed.",

author = "Castedo, \{Sergio M.M.J.\} and \{de Jong\}, Bauke and Raquel Seruca and \{te Meerman\}, Gerard and Idenburg, \{Vera J.S.\} and Oosterhuis, \{J. Wolter\} and Anke Dam and Koops, \{Heimen Schraffordt\} and Sleijfer, \{Dirk T.\}",

year = "1989",

month = oct,

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T1 - Chromosomal Changes in Human Primary Testicular Nonseminomatous Germ Cell Tumors

AU - Castedo, Sergio M.M.J.

AU - de Jong, Bauke

AU - Seruca, Raquel

AU - te Meerman, Gerard

AU - Idenburg, Vera J.S.

AU - Oosterhuis, J. Wolter

AU - Dam, Anke

AU - Koops, Heimen Schraffordt

AU - Sleijfer, Dirk T.

PY - 1989/10/15

Y1 - 1989/10/15

N2 - A cytogenetic analysis of 14 primary testicular nonseminomatous germ cell tumors has been carried out after short term tissue culture. The modal chromosome numbers ranged from 53 to 113, in agreement with flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. Two tumors, however, lacked that marker. Some chromosomes are apparently overrepresented, whereas others are underrepresented, although some differences between seminomas and nonseminomas were noticed.

AB - A cytogenetic analysis of 14 primary testicular nonseminomatous germ cell tumors has been carried out after short term tissue culture. The modal chromosome numbers ranged from 53 to 113, in agreement with flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. Two tumors, however, lacked that marker. Some chromosomes are apparently overrepresented, whereas others are underrepresented, although some differences between seminomas and nonseminomas were noticed.

UR - https://www.scopus.com/pages/publications/0024457239

M3 - Article

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AN - SCOPUS:0024457239

SN - 0008-5472

VL - 49

SP - 5696

EP - 5701

JO - Cancer Research

JF - Cancer Research

IS - 20

ER -

Chromosomal Changes in Human Primary Testicular Nonseminomatous Germ Cell Tumors

Abstract

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