Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells

A. Geurts van Kessel; E. van Drunen; B. de Jong; J. W. Oosterhuis; A. Langeveld; M. P. Mulder

doi:10.1016/0165-4608(89)90154-4

Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells

A. Geurts van Kessel, E. van Drunen, B. de Jong, J. W. Oosterhuis, A. Langeveld, M. P. Mulder

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Abstract

Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.

Original language	English
Pages (from-to)	129-134
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(89)90154-4
Publication status	Published - 1 Jul 1989
Externally published	Yes

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title = "Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells",

abstract = "Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.",

author = "{Geurts van Kessel}, A. and {van Drunen}, E. and {de Jong}, B. and Oosterhuis, {J. W.} and A. Langeveld and Mulder, {M. P.}",

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T1 - Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells

AU - Geurts van Kessel, A.

AU - van Drunen, E.

AU - de Jong, B.

AU - Oosterhuis, J. W.

AU - Langeveld, A.

AU - Mulder, M. P.

PY - 1989/7/1

Y1 - 1989/7/1

N2 - Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.

AB - Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.

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AN - SCOPUS:0024457682

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JF - Cancer Genetics and Cytogenetics

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Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells

Abstract

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