Circumvention of glucocorticoid resistance in childhood leukemia

E. G. Haarman; G. J.L. Kaspers; R. Pieters; M. M.A. Rottier; A. J.P. Veerman

doi:10.1016/j.leukres.2008.02.009

Circumvention of glucocorticoid resistance in childhood leukemia

E. G. Haarman
, G. J.L. Kaspers
, R. Pieters
, M. M.A. Rottier
, A. J.P. Veerman

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.

Original language	English
Pages (from-to)	1417-1423
Number of pages	7
Journal	Leukemia research
Volume	32
Issue number	9
DOIs	https://doi.org/10.1016/j.leukres.2008.02.009
Publication status	Published - Sept 2008
Externally published	Yes

Keywords

Childhood leukemia
Cortivazol
Glucocorticoid resistance
Meta-iodobenzylguanidine

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10.1016/j.leukres.2008.02.009

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@article{2b85acfa06a64422962979344d242265,

title = "Circumvention of glucocorticoid resistance in childhood leukemia",

abstract = "In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50\% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19\% of the lymphoblastic leukemia samples.",

keywords = "Childhood leukemia, Cortivazol, Glucocorticoid resistance, Meta-iodobenzylguanidine",

author = "Haarman, \{E. G.\} and Kaspers, \{G. J.L.\} and R. Pieters and Rottier, \{M. M.A.\} and Veerman, \{A. J.P.\}",

note = "Funding Information: This project was supported by the Dutch Cancer Society and EUGIA. We would like to thank, A.J.F. Broekhuizen, D.R. Huismans, A.H. Loonen, and C.H. van Zantwijk for their excellent technical assistance.",

year = "2008",

month = sep,

doi = "10.1016/j.leukres.2008.02.009",

language = "English",

volume = "32",

pages = "1417--1423",

journal = "Leukemia research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "9",

}

TY - JOUR

T1 - Circumvention of glucocorticoid resistance in childhood leukemia

AU - Haarman, E. G.

AU - Kaspers, G. J.L.

AU - Pieters, R.

AU - Rottier, M. M.A.

AU - Veerman, A. J.P.

N1 - Funding Information: This project was supported by the Dutch Cancer Society and EUGIA. We would like to thank, A.J.F. Broekhuizen, D.R. Huismans, A.H. Loonen, and C.H. van Zantwijk for their excellent technical assistance.

PY - 2008/9

Y1 - 2008/9

N2 - In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.

AB - In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.

KW - Childhood leukemia

KW - Cortivazol

KW - Glucocorticoid resistance

KW - Meta-iodobenzylguanidine

UR - https://www.scopus.com/pages/publications/43249104941

U2 - 10.1016/j.leukres.2008.02.009

DO - 10.1016/j.leukres.2008.02.009

M3 - Article

C2 - 18395253

AN - SCOPUS:43249104941

SN - 0145-2126

VL - 32

SP - 1417

EP - 1423

JO - Leukemia research

JF - Leukemia research

IS - 9

ER -

Circumvention of glucocorticoid resistance in childhood leukemia

Abstract

Keywords

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