Clinical Characteristics of Invasive Fungal Infections in Pediatric Oncology Patients with Solid Tumors

Veerle J. Ruijters; Natanja Oosterom; Madeleine E.M. Van Der Perk; Tom F.W. Wolfs; Annelot J.M. Meijer; Marry M. Van Den Heuvel-Eibrink; Martine Van Grotel

doi:10.1097/MPH.0000000000001761

Clinical Characteristics of Invasive Fungal Infections in Pediatric Oncology Patients with Solid Tumors

Veerle J. Ruijters
, Natanja Oosterom
, Madeleine E.M. Van Der Perk
, Tom F.W. Wolfs
, Annelot J.M. Meijer
, Marry M. Van Den Heuvel-Eibrink
, Martine Van Grotel

Group van den Heuvel

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics of IFI in children with solid tumors are limited. This Dutch retrospective cohort study reviewed the medical records of 61 children with solid tumors to analyze the clinical characteristics during their full treatment period. Seven IFI episodes were reported in 6/61 patients (10%), all diagnosed with intermediate-risk or high-risk Wilms tumor or neuroblastoma. Larger studies are necessary to reveal the determinants of IFI in this group of patients and the value of fungal prophylaxis.

Original language	English
Pages (from-to)	e408-e413
Journal	Journal of pediatric hematology/oncology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1097/MPH.0000000000001761
Publication status	Published - Apr 2021

Keywords

clinical characteristics
frequency
invasive fungal infections
pediatric oncology patients

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10.1097/MPH.0000000000001761

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title = "Clinical Characteristics of Invasive Fungal Infections in Pediatric Oncology Patients with Solid Tumors",

abstract = "Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics of IFI in children with solid tumors are limited. This Dutch retrospective cohort study reviewed the medical records of 61 children with solid tumors to analyze the clinical characteristics during their full treatment period. Seven IFI episodes were reported in 6/61 patients (10\%), all diagnosed with intermediate-risk or high-risk Wilms tumor or neuroblastoma. Larger studies are necessary to reveal the determinants of IFI in this group of patients and the value of fungal prophylaxis.",

keywords = "clinical characteristics, frequency, invasive fungal infections, pediatric oncology patients",

author = "Ruijters, \{Veerle J.\} and Natanja Oosterom and \{Van Der Perk\}, \{Madeleine E.M.\} and Wolfs, \{Tom F.W.\} and Meijer, \{Annelot J.M.\} and \{Van Den Heuvel-Eibrink\}, \{Marry M.\} and \{Van Grotel\}, Martine",

year = "2021",

month = apr,

doi = "10.1097/MPH.0000000000001761",

language = "English",

volume = "43",

pages = "e408--e413",

journal = "Journal of pediatric hematology/oncology",

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TY - JOUR

T1 - Clinical Characteristics of Invasive Fungal Infections in Pediatric Oncology Patients with Solid Tumors

AU - Ruijters, Veerle J.

AU - Oosterom, Natanja

AU - Van Der Perk, Madeleine E.M.

AU - Wolfs, Tom F.W.

AU - Meijer, Annelot J.M.

AU - Van Den Heuvel-Eibrink, Marry M.

AU - Van Grotel, Martine

PY - 2021/4

Y1 - 2021/4

N2 - Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics of IFI in children with solid tumors are limited. This Dutch retrospective cohort study reviewed the medical records of 61 children with solid tumors to analyze the clinical characteristics during their full treatment period. Seven IFI episodes were reported in 6/61 patients (10%), all diagnosed with intermediate-risk or high-risk Wilms tumor or neuroblastoma. Larger studies are necessary to reveal the determinants of IFI in this group of patients and the value of fungal prophylaxis.

AB - Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics of IFI in children with solid tumors are limited. This Dutch retrospective cohort study reviewed the medical records of 61 children with solid tumors to analyze the clinical characteristics during their full treatment period. Seven IFI episodes were reported in 6/61 patients (10%), all diagnosed with intermediate-risk or high-risk Wilms tumor or neuroblastoma. Larger studies are necessary to reveal the determinants of IFI in this group of patients and the value of fungal prophylaxis.

KW - clinical characteristics

KW - frequency

KW - invasive fungal infections

KW - pediatric oncology patients

UR - https://www.scopus.com/pages/publications/85103473790

U2 - 10.1097/MPH.0000000000001761

DO - 10.1097/MPH.0000000000001761

M3 - Article

C2 - 32097283

AN - SCOPUS:85103473790

SN - 1077-4114

VL - 43

SP - e408-e413

JO - Journal of pediatric hematology/oncology

JF - Journal of pediatric hematology/oncology

IS - 3

ER -

Clinical Characteristics of Invasive Fungal Infections in Pediatric Oncology Patients with Solid Tumors

Abstract

Keywords

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