Clinical evaluation of vancomycin dosage in pediatric oncology patients

Stefan J.W.J. Sanders; Yuma A. Bijleveld; Fleur Sinkeler; Elles M. Kemper; Dasja Pajkrt; Marianne Van De Wetering; Natasha K.A. Van Eijkelenburg; Ron A.A. Mathôt

doi:10.1097/INF.0000000000000268

Clinical evaluation of vancomycin dosage in pediatric oncology patients

Stefan J.W.J. Sanders, Yuma A. Bijleveld, Fleur Sinkeler, Elles M. Kemper, Dasja Pajkrt, Marianne Van De Wetering, Natasha K.A. Van Eijkelenburg, Ron A.A. Mathôt

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

Original language	English
Pages (from-to)	731-733
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	33
Issue number	7
DOIs	https://doi.org/10.1097/INF.0000000000000268
Publication status	Published - Jul 2014
Externally published	Yes

Keywords

pediatric oncology
serum concentrations
vancomycin

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10.1097/INF.0000000000000268

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abstract = "Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.",

keywords = "pediatric oncology, serum concentrations, vancomycin",

author = "Sanders, {Stefan J.W.J.} and Bijleveld, {Yuma A.} and Fleur Sinkeler and Kemper, {Elles M.} and Dasja Pajkrt and {Van De Wetering}, Marianne and {Van Eijkelenburg}, {Natasha K.A.} and Math{\^o}t, {Ron A.A.}",

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AU - Bijleveld, Yuma A.

AU - Sinkeler, Fleur

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AU - Pajkrt, Dasja

AU - Van De Wetering, Marianne

AU - Van Eijkelenburg, Natasha K.A.

AU - Mathôt, Ron A.A.

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AB - Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

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KW - serum concentrations

KW - vancomycin

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Clinical evaluation of vancomycin dosage in pediatric oncology patients

Abstract

Keywords

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