Clinical evaluation of vancomycin dosage in pediatric oncology patients

Stefan J.W.J. Sanders; Yuma A. Bijleveld; Fleur Sinkeler; Elles M. Kemper; Dasja Pajkrt; Marianne Van De Wetering; Natasha K.A. Van Eijkelenburg; Ron A.A. Mathôt

doi:10.1097/INF.0000000000000268

Clinical evaluation of vancomycin dosage in pediatric oncology patients

Stefan J.W.J. Sanders
, Yuma A. Bijleveld
, Fleur Sinkeler
, Elles M. Kemper
, Dasja Pajkrt
, Marianne Van De Wetering
, Natasha K.A. Van Eijkelenburg
, Ron A.A. Mathôt

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

Original language	English
Pages (from-to)	731-733
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	33
Issue number	7
DOIs	https://doi.org/10.1097/INF.0000000000000268
Publication status	Published - Jul 2014
Externally published	Yes

Keywords

pediatric oncology
serum concentrations
vancomycin

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10.1097/INF.0000000000000268

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title = "Clinical evaluation of vancomycin dosage in pediatric oncology patients",

abstract = "Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58\% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.",

keywords = "pediatric oncology, serum concentrations, vancomycin",

author = "Sanders, \{Stefan J.W.J.\} and Bijleveld, \{Yuma A.\} and Fleur Sinkeler and Kemper, \{Elles M.\} and Dasja Pajkrt and \{Van De Wetering\}, Marianne and \{Van Eijkelenburg\}, \{Natasha K.A.\} and Math{\^o}t, \{Ron A.A.\}",

year = "2014",

month = jul,

doi = "10.1097/INF.0000000000000268",

language = "English",

volume = "33",

pages = "731--733",

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T1 - Clinical evaluation of vancomycin dosage in pediatric oncology patients

AU - Sanders, Stefan J.W.J.

AU - Bijleveld, Yuma A.

AU - Sinkeler, Fleur

AU - Kemper, Elles M.

AU - Pajkrt, Dasja

AU - Van De Wetering, Marianne

AU - Van Eijkelenburg, Natasha K.A.

AU - Mathôt, Ron A.A.

PY - 2014/7

Y1 - 2014/7

N2 - Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

AB - Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

KW - pediatric oncology

KW - serum concentrations

KW - vancomycin

UR - https://www.scopus.com/pages/publications/84902549373

U2 - 10.1097/INF.0000000000000268

DO - 10.1097/INF.0000000000000268

M3 - Article

C2 - 24445830

AN - SCOPUS:84902549373

SN - 0891-3668

VL - 33

SP - 731

EP - 733

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 7

ER -

Clinical evaluation of vancomycin dosage in pediatric oncology patients

Abstract

Keywords

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