Clinicopathological features of medulloblastoma: An overview with an emphasis on molecular biology

T. G.K.J. De Haas, M. Kool

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Medulloblastoma is a malignant, invasive embryonal tumor of the cerebellum with preferential manifestation in children, predominantly neuronal differentiation and an inherent tendency to metastasize via CSF pathways. In this review we present an overview of the clinicopathological aspects of medulloblastoma and the recent developments in the biology and genetics of these embryonal brain tumors. Increased knowledge of the signaling pathways that play a role in normal cerebellum development and tumor formation may lead to new therapeutic approaches resulting in a higher cure rate and a better quality of life of medulloblastoma patients.

Original languageEnglish
Pages (from-to)93-110
Number of pages18
JournalClinical Neuropathology
Volume26
Issue number3
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Cerebellum
  • Embryonal brain tumor
  • Medulloblastoma

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